Multi-agent chemotherapy for early breast cancer

Reduced ovarian reserve in young early breast cancer patients: preliminary data from a prospective cohort trial

“…Nevertheless, we lack knowledge of their precise effects on ovarian function and fertility. Adjuvant chemotherapy is indicated for patients with a high risk of recurrent disease [ 2 ]. Endocrine therapy is recommended for all tumors that express the estrogen (ER) and/or progesterone receptor (PR).…”

Reduced ovarian reserve in young early breast cancer patients: preliminary data from a prospective cohort trial

“…Nevertheless, we lack knowledge of their precise effects on ovarian function and fertility. Adjuvant chemotherapy is indicated for patients with a high risk of recurrent disease [ 2 ]. Endocrine therapy is recommended for all tumors that express the estrogen (ER) and/or progesterone receptor (PR).…”

Survival Rate of Breast Cancer Patients who Participated in Clinicals Trials Versus those who did not

“…However, less than 10% of cancer patients participate in CTs [3]. Between 1990 and 2011, breast cancer mortality in Canada dropped from 31.3/100,000 to 20.7/100,000 (adjusted for age) [4], and the following hypotheses may explain this decrease: large-scale screening for early-stage cancer [1], more aggressive adjuvant therapies [2,5] and more effective treatments of metastatic diseases [6]. These hypotheses have one common feature: the interventions have been studied and proven to be more effective than previous standards in CTs.…”

Melatonin Suppresses the Expression of 45S Preribosomal RNA and Upstream Binding Factor and Enhances the Antitumor Activity of Puromycin in MDA-MB-231 Breast Cancer Cells

“…Though several drugs such as tamoxifen, doxorubicin, and raloxifene have been clinically used to reduce the risk of breast cancer, side effects and resistance to chemotherapy are still hot issues [1]. Thus, the combined therapy of commercial anticancer agents with natural compounds is considered as an attractive strategy to reduce side effects or resistance, since it can meet the antitumor efficacy with lower doses of anticancer agents.…”

Reduced ovarian reserve in young early breast cancer patients: preliminary data from a prospective cohort trial

“…Nevertheless, we lack knowledge of their precise effects on ovarian function and fertility. Adjuvant chemotherapy is indicated for patients with a high risk of recurrent disease [ 2 ]. Endocrine therapy is recommended for all tumors that express the estrogen (ER) and/or progesterone receptor (PR).…”

Survival Rate of Breast Cancer Patients who Participated in Clinicals Trials Versus those who did not

“…However, less than 10% of cancer patients participate in CTs [3]. Between 1990 and 2011, breast cancer mortality in Canada dropped from 31.3/100,000 to 20.7/100,000 (adjusted for age) [4], and the following hypotheses may explain this decrease: large-scale screening for early-stage cancer [1], more aggressive adjuvant therapies [2,5] and more effective treatments of metastatic diseases [6]. These hypotheses have one common feature: the interventions have been studied and proven to be more effective than previous standards in CTs.…”

Melatonin Suppresses the Expression of 45S Preribosomal RNA and Upstream Binding Factor and Enhances the Antitumor Activity of Puromycin in MDA-MB-231 Breast Cancer Cells

“…Though several drugs such as tamoxifen, doxorubicin, and raloxifene have been clinically used to reduce the risk of breast cancer, side effects and resistance to chemotherapy are still hot issues [1]. Thus, the combined therapy of commercial anticancer agents with natural compounds is considered as an attractive strategy to reduce side effects or resistance, since it can meet the antitumor efficacy with lower doses of anticancer agents.…”

Reduced ovarian reserve in young early breast cancer patients: preliminary data from a prospective cohort trial

“…Nevertheless, we lack knowledge of their precise effects on ovarian function and fertility. Adjuvant chemotherapy is indicated for patients with a high risk of recurrent disease [ 2 ]. Endocrine therapy is recommended for all tumors that express the estrogen (ER) and/or progesterone receptor (PR).…”

Survival Rate of Breast Cancer Patients who Participated in Clinicals Trials Versus those who did not

“…However, less than 10% of cancer patients participate in CTs [3]. Between 1990 and 2011, breast cancer mortality in Canada dropped from 31.3/100,000 to 20.7/100,000 (adjusted for age) [4], and the following hypotheses may explain this decrease: large-scale screening for early-stage cancer [1], more aggressive adjuvant therapies [2,5] and more effective treatments of metastatic diseases [6]. These hypotheses have one common feature: the interventions have been studied and proven to be more effective than previous standards in CTs.…”

Melatonin Suppresses the Expression of 45S Preribosomal RNA and Upstream Binding Factor and Enhances the Antitumor Activity of Puromycin in MDA-MB-231 Breast Cancer Cells

“…Though several drugs such as tamoxifen, doxorubicin, and raloxifene have been clinically used to reduce the risk of breast cancer, side effects and resistance to chemotherapy are still hot issues [1]. Thus, the combined therapy of commercial anticancer agents with natural compounds is considered as an attractive strategy to reduce side effects or resistance, since it can meet the antitumor efficacy with lower doses of anticancer agents.…”