Mud-bath therapy regulates the expression levels of microRNA in osteoarthritis. Epigenetic contribution to explain the mechanism of action of Balneotherapy

Abstract

MicroRNAs (miRNAs) play an important role in the pathogenesis of osteoarthritis (OA); they have been detected in human plasma and in synovial fluid and are considered as potential diagnostic biomarkers and therapeutic targets of OA.Balneotherapy is a common non-pharmacological treatment for OA patients, with a beneficial effect on pain, function and quality of life and a favourable economic profile.Purpose: The aim of our study was to evaluate the whole-blood levels of miR-155, miR-223, miR-181a, miR-146a and …