Mucous membrane involvement in generalized pustular psoriasis: Report of three cases and review of the literature

Abstract

Pustular eruptions on both skin and mucous membranes occur in the various forms of generalized pustular psoriasis. Three patients with generalized pustular psoriasis also had an eruption on the tongue resembling geographic tongue; one patient had sterile conjunctivitis. Histologically, the spongiform pustule of Kogoj is common to lesions of both skin and mucosa. We suggest that generalized pustular psoriasis be considered one of the mucocutaneous syndromes.

A case of pustular psoriasis in a young boy.

“…This was a case of pustular psoriasis in a young boy who presented with erythroderma which is a rare presentation of pustular psoriasis. The occurrence of mucosal involvement is also rare and was found in this patient who had sterile conjunctivitis [7]. The commoner presentation of pustular psoriasis in Malaysia are fever, painful skin, arthritis and leucocytosis [8].…”

Gastrointestinal bleeding with severe mucosal involvement in a patient with generalized pustular psoriasis without IL36RN mutation

“…Generalized pustular psoriasis (GPP) is a systemic inflammatory disease that presents with erythema and sterile pustules, pathologically characterized by Kogoj's spongiform pustules. GPP is sometimes accompanied by mucosal involvement, and the most common lesion is on the tongue . We herein report a GPP patient with severe mucosal involvement, consequently causing gastrointestinal bleeding.…”

“…GPP is sometimes accompanied by mucosal involvement, and the most common lesion is on the tongue. 1,2 We herein report a GPP patient with severe mucosal involvement, consequently causing gastrointestinal bleeding.…”

Autoinflammatory Pustular Neutrophilic Diseases

“…Some speculate that these oral manifestations may represent a forme fruste of pustular psoriasis 92 , while others believe oral mucosal manifestations are a harbinger of GPP 91, 94 . The most commonly reported ocular manifestation is purulent sterile conjunctivitis 11, 12, 95, 96 , however iridocyclitis 12 , corneal ulceration 12 and corneal exfoliation 97 may develop.…”