Mucocutaneous Lichen Planus With Esophageal Involvement

Parmentier, Laurent; Bron, Blaise-Alain; Prins, Christa; Samson, Jacky; Masouyé, Isabelle; Borradori, Luca

doi:10.1001/archderm.144.11.1427

Cited by 38 publications

(7 citation statements)

References 19 publications

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“…Numerous other therapies have been described including retinoids such as etretinate (1,32,34,48,49), adrenocorticotropic hormone (50), cyclosporine (35), topical tacrolimus and/or intralesional steroids (41,49,51), rituximab (52), and adalimumab (1). Combination therapy also may be efficacious.…”

Section: Medical Treatmentmentioning

confidence: 99%

Demystifying Esophageal Lichen Planus: A Comprehensive Review of a Rare Disease You Will See in Practice

et al. 2021

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Lichen planus (LP) is a chronic inflammatory disorder that often affects the skin, hair, nails, and mucus membranes. Although esophageal involvement has traditionally been felt to be rare, recent reports suggest that it is often unrecognized or misdiagnosed. The diagnoses of esophageal lichen planus can be challenging and is suspected based on patients' endoscopic and histologic findings and in the context of their clinical history and physical examination. Physicians must have an index of suspicion, particularly in older white women and in those patients with an atypical esophagitis or stricturing disease, which do not respond to traditional treatment. Currently, there are limited data on esophageal lichen planus patients, and no formal management guidelines for this disease, which all gastroenterologists will see in practice. This article reviews the etiology and histopathology of LP and provides a comprehensive discussion of the clinical features, diagnosis, and management of esophageal disease from the gastroenterologist's perspective. Finally, we address the esophageal complications of LP.

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Section: Medical Treatmentmentioning

confidence: 99%

Demystifying Esophageal Lichen Planus: A Comprehensive Review of a Rare Disease You Will See in Practice

et al. 2021

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“…It is noteworthy that rituximab activity leads to the suppression of antigen presentation, the inhibition of T-cell recruitment, and the IFN-alpha pathway preventing, eventually, B-cell expansion [6, 12]. For this beneficial effect, recently, it has been used to treat severe and persistent lichenoid drug reaction [12, 21, 22].…”

Section: Discussionmentioning

confidence: 99%

Oral Lichenoid Reaction: An Uncommon Side Effect of Rituximab

Giudice

Liborio

Averta

et al. 2019

Case Reports in Dentistry

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Oral lichenoid reactions (OLR) can be caused by systemic drug exposure. To the best of our knowledge, this is the second report describing a case of OLR induced by rituximab administration in a patient with a diagnosis of non-Hodgkin B-cell lymphoma. After 5 doses of rituximab, a typical pattern of OLP was identified with bilateral and symmetrical lesions on the buccal mucosa and on the right lingual margin. This temporal relationship suggested a probable association between oral lesions and drug therapy. The clinical diagnosis of a rituximab-induced OLR was confirmed by an incisional biopsy reporting a histopathological result of lichenoid mucositis consistent with oral lichen planus. Because of the increasing use of rituximab, it is necessary to know and recognize this uncommon side effect.

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“…In the present case, we recommended switching from oral corticosteroids to swallowed fluticasone propionate; however, the patient refused this recommendation because swallowed fluticasone was not covered by Japanese insurance. In isolated cases, patients have been successfully treated with oral tacrolimus ( 19 ), alitretinoin ( 20 ), and rituximab ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

A Japanese Case of Esophageal Lichen Planus that Was Successfully Treated with Systemic Corticosteroids

et al. 2018

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Esophageal lichen planus (ELP) is rare and only about 80 cases have been reported in the literature. An 85-year-old woman presented with dysphagia and odynophagia. Endoscopy revealed a severe stricture in the proximal esophagus. Oral examinations at two years after the first endoscopy revealed erosions around the gingiva, and an examination of biopsy specimens taken from the site of erosion led to a diagnosis of oral lichen planus. Esophageal endoscopy was performed again, and biopsy specimens showed spongiosis and necrotic keratinocytes in the epithelium (civatte bodies). The patient was diagnosed with ELP and was treated with systemic corticosteroids, which resulted in clinical relief.

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Mucocutaneous Lichen Planus With Esophageal Involvement

Cited by 38 publications

References 19 publications

Demystifying Esophageal Lichen Planus: A Comprehensive Review of a Rare Disease You Will See in Practice

Demystifying Esophageal Lichen Planus: A Comprehensive Review of a Rare Disease You Will See in Practice

Oral Lichenoid Reaction: An Uncommon Side Effect of Rituximab

A Japanese Case of Esophageal Lichen Planus that Was Successfully Treated with Systemic Corticosteroids

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