Mucinous sweat gland adenocarcinoma of eyelid.A clinicopathologic study of 21 cases with histochemical and electron microscopic observations

Abstract

This is a clinicopathologic study of 21 cases of mucinous sweat gland adenocarcinoma involving the eyelid. The tumor occurred in middle-aged adults (median age 60 years) and has a predilection for males. In this series eight patients (40%) had one or more local recurrences, one of whom died with extensive local invasion of the face after multiple recurrences in a 15-year interval. Only one patient had metastasis to the submandibular lymph nodes, which was treated by radical neck dissection. Involvement of the head, especially the face and scalp, was observed in 78% of the cases from the literature. Combining our cases with those previously reported, we found that the eyelid was involved in almost half of the cases (21 out of 45 lesions).We believe that the identification by light microscopy of a mixed population of light and dark secretory cells within the tumor lobules, the histochemical findings (presence of sialomucin and absence of iron as well as periodic acid-Schiff positive, diastase-resistant granules), and the results of ultrastructural studies support the histogenetic postulate that this mucinous adenocarcinoma is probably derived from the secretory cells of the eccrine coil. Our interpretation concurs with Headington's view of origin from the eccrine glands.'j

Primary Mucinous Eccrine Adenocarcinoma – A Rare Malignant Cutaneous Adnexal Neoplasm at an Unconventional Site

“…Local recurrences are known to occur frequently in these tumours, but they rarely metastasize. Death following metastatic spread has been reported in three cases as per literature review [7,9]. No metastasis was detected in the present case.…”

“…Primary cutaneous mucinous carcinomas are slow-growing tumours with a local recurrence rate of 29.4% following excision and a low metastatic rate of 9.6% [6,7]. Majority of these tumours metastasize to regional lymph nodes.…”

Primary cutaneous mucinous carcinoma of the penis

“…4 Only 3 cases of death attributed to metastatic disease have been reported. [5][6][7] In a previous review of the literature that identified 206 published cases, 150 cases involved the head (eyelids, face, scalp, neck), while 7 involved the vulva. 8 There were no cases of PCMC involving the penis identified in our search of the PubMed database limited to publications in English.…”

A Case of Primary Cutaneous Mucinous Carcinoma with Neuroendocrine Differentiation

“…It is a rare malignant tumor related to the eccrine sweat duct and is commonly located on the face, especially around the eyelids, and scalp 3,4 . It is usually solitary and grows asymptomatically over several months or even years 3 . Histopathology shows a circumscribed tumor with large amounts of mucin separated by fibrous septae and containing scattered floating islands of epithelial cells.…”