2010
DOI: 10.1590/s0365-05962010000100014
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Abstract: Resumo: A mucinose papulosa ou líquen mixedematoso é doença idiopática, manifestada por pápulas, nódulos ou placas por depósito de mucina na derme, na ausência de doença tireoidiana. Apresentamos um caso atípico, com lesões exuberantes em placas, associado ao hipotireoidismo subclínico. Nas mucinoses cutâneas há quantidade anormal de mucina na pele. Tradicionalmente as classificações consideram critério diagnóstico para mucinose papulosa a ausência de doença tireoidiana. Poucos casos associados ao hipotireoidi… Show more

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Cited by 9 publications
(7 citation statements)
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“…Rongioletti and Rebora [1] may include the absence of thyroid disease as part of the diagnosis because hypothyroidism can present with generalized myxedema and histology showing mucin deposition [3]. However, there are multiple cases of scleromyxedema and LM in addition to ours that have been diagnosed with concurrent thyroid disease [2, 4, 5]. Our patients presented with forms of papular mucinosis years after hypothyroidism had been diagnosed and sufficiently treated.…”
Section: Discussionmentioning
confidence: 85%
“…Rongioletti and Rebora [1] may include the absence of thyroid disease as part of the diagnosis because hypothyroidism can present with generalized myxedema and histology showing mucin deposition [3]. However, there are multiple cases of scleromyxedema and LM in addition to ours that have been diagnosed with concurrent thyroid disease [2, 4, 5]. Our patients presented with forms of papular mucinosis years after hypothyroidism had been diagnosed and sufficiently treated.…”
Section: Discussionmentioning
confidence: 85%
“…Scalp and mucosae are not affected. 1,4 They may coalesce, resulting in widespread induration of the skin and eventually leading to leonine facies and microstomia. 1,2 …”
Section: Discussionmentioning
confidence: 99%
“…Papular mucinosis associated with thyroid dysfunction has been reported previously, which, as in the present report, represent cases of atypical lichen myxedematosus. [2345] We reviewed earlier literatures and found that a subtype called papular mucinosis associated with thyroid disorder was reported before, which however, is not present in the updated classification due to its rarity. Moreover, reports that thyroid hormone replacement therapy led to an improvement in cutaneous mucinosis associated with hypothyroidism reinforced the association between these two metabolic diseases.…”
mentioning
confidence: 99%
“…There is evidence that in hypothyroidism the excess accumulation of hyaluronic acid in the skin and other tissues results from a proportionally greater reduction in its degradation compared with its synthesis. [2] However, the exact relationship between these two diseases remains to be further studied. Besides, the course of the atypical forms is unpredictable and should be followed up carefully.…”
mentioning
confidence: 99%