Mucin-bacterial interactions in the human oral cavity and digestive tract

Derrien, Muriel; Passel, Mark Wj van; Bovenkamp, Jeroen Hb van de; Schipper, Raymond G.; Vos, Willem M. de; Dekker, Jan

doi:10.4161/gmic.1.4.12778

Cited by 469 publications

(480 citation statements)

References 188 publications

(126 reference statements)

Supporting

Mentioning

428

Contrasting

Unclassified

Order By: Relevance

“…Indeed, we were surprised to detect this mucin-degrading gut bacterium in breast milk, notwithstanding its previously reported presence among gut microbiota in infants (31). Given its capability to degrade intestinal mucus, Akkermansia muciniphila may indirectly affect the innate and adaptive immune responses (32). In light of the findings of a recent metagenomic study, however, the cascade of events linking Akkermansia muciniphila to the pathogenesis of inflammatory diseases may have been misinterpreted; although this microorganism contains numerous candidate mucinase-encoding genes, it lacks genes encoding canonical mucus-binding domains, and may thereby actually protect the mucus lining by controlling other mucosa degraders (33).…”

Section: Maternal Bmi Impact On Milk Componentsmentioning

confidence: 89%

“…In light of the findings of a recent metagenomic study, however, the cascade of events linking Akkermansia muciniphila to the pathogenesis of inflammatory diseases may have been misinterpreted; although this microorganism contains numerous candidate mucinase-encoding genes, it lacks genes encoding canonical mucus-binding domains, and may thereby actually protect the mucus lining by controlling other mucosa degraders (33). Akkermansia muciniphila has not been correlated with any disease or sign of pathogenicity, and is an inhabitant of the gut microbial ecosystem (32,33).…”

Section: Maternal Bmi Impact On Milk Componentsmentioning

confidence: 99%

See 1 more Smart Citation

Maternal weight and excessive weight gain during pregnancy modify the immunomodulatory potential of breast milk

et al. 2012

View full text Add to dashboard Cite

IntroductIon: Breast milk is an optimal source of nutrition for infants. It contains bioactive components including bacteria that support the microbial colonization and immune system development of the infant. The determinants of human milk composition remain poorly understood, although maternal nutritional and immunological status as well as lifestyle and dietary habits seem to have an impact. Methods: The subjects selected were women from a prospective follow-up study categorized by BMI. Milk samples were taken after delivery and at 1 and 6 mo later for analysis of composition in regard to transforming growth factor (TGF)-β2, soluble cD14 (scD14), cytokines, and microbiota. results: TGF-β2 and scD14 levels in the breast milk of overweight mothers tended to be lower than the levels in that of normal-weight mothers. also, higher levels of Staphylococcus group bacteria and lower levels of Bifidobacterium group bacteria were detected in overweight mothers as compared with normal-weight ones. The prevalence of Akkermansia muciniphila-type bacteria was also higher in overweight mothers, and the numbers of these bacteria were related to the interleukin (IL)-6 concentration in the colostrum, which was in turn related to lower counts of Bifidobacterium group bacteria in the breast milk of overweight women. dIscussIon: complex interactions of cytokines and microbiota in breast milk guide the microbiological, immunological, and metabolic programming of infant health. Our data may indicate the presence of an additional mechanism that may explain the heightened risk of obesity for infants of overweight and excessive weight gain mothers.

show abstract

Section: Maternal Bmi Impact On Milk Componentsmentioning

confidence: 89%

Section: Maternal Bmi Impact On Milk Componentsmentioning

confidence: 99%

Maternal weight and excessive weight gain during pregnancy modify the immunomodulatory potential of breast milk

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The don genes are significantly induced by a crude mixture of gastric mucin glycans and in fact, they were the most highly induced of all genes in mucin glycan medium (SI Appendix, Table S1). One potential role for the Don PUL may be to harvest the high quality complex N-linked mucus glycans (which make up about 20% of mucus glycans) (25), as cells transit through the mucus layers to the crypts. Other host-associated N-linked glycan sources may become available to bacteria adherent in the crypts, or the don operon may be shut down because don transcription is negligible in the absence of an inducer.…”

Section: Discussionmentioning

confidence: 99%

Efficient utilization of complex N-linked glycans is a selective advantage for Bacteroides fragilis in extraintestinal infections

Cao

Rocha

Smith

2014

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Bacteroides fragilis is the most common anaerobe isolated from clinical infections, and in this report we demonstrate a characteristic of the species that is critical to their success as an opportunistic pathogen. Among the Bacteroides spp. in the gut, B. fragilis has the unique ability of efficiently harvesting complex N-linked glycans from the glycoproteins common to serum and serous fluid. This activity is mediated by an outer membrane protein complex designated as Don. Using the abundant serum glycoprotein transferrin as a model, it has been shown that B. fragilis alone can rapidly and efficiently deglycosylate this protein in vitro and that transferrin glycans can provide the sole source of carbon and energy for growth in defined media. We then showed that transferrin deglycosylation occurs in vivo when B. fragilis is propagated in the rat tissue cage model of extraintestinal growth, and that this ability provides a competitive advantage in vivo over strains lacking the don locus.

show abstract

“…4C). The high level of UCC2003-tadAPK1 shedding may be caused by the structure of the GIT in the animals that were germ-free or monoassociated with bifidobacteria; the cecum is five times larger in these mice than in conventional animals (55). Therefore this organ may function as a suitable niche for B. breve UCC2003 in the absence of any competing Fig.…”

mentioning

confidence: 99%

Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor

Motherway

Zomer²,

Leahy

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

332

337

View full text Add to dashboard Cite

Development of the human gut microbiota commences at birth, with bifidobacteria being among the first colonizers of the sterile newborn gastrointestinal tract. To date, the genetic basis of Bifidobacterium colonization and persistence remains poorly understood. Transcriptome analysis of the Bifidobacterium breve UCC2003 2.42-Mb genome in a murine colonization model revealed differential expression of a type IVb tight adherence (Tad) pilus-encoding gene cluster designated "tad 2003 ." Mutational analysis demonstrated that the tad 2003 gene cluster is essential for efficient in vivo murine gut colonization, and immunogold transmission electron microscopy confirmed the presence of Tad pili at the poles of B. breve UCC2003 cells. Conservation of the Tad pilus-encoding locus among other B. breve strains and among sequenced Bifidobacterium genomes supports the notion of a ubiquitous pili-mediated host colonization and persistence mechanism for bifidobacteria.fimbriae | probiotic | prebiotic | genomics

show abstract

Mucin-bacterial interactions in the human oral cavity and digestive tract

Cited by 469 publications

References 188 publications

Maternal weight and excessive weight gain during pregnancy modify the immunomodulatory potential of breast milk

Maternal weight and excessive weight gain during pregnancy modify the immunomodulatory potential of breast milk

Efficient utilization of complex N-linked glycans is a selective advantage for Bacteroides fragilis in extraintestinal infections

Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor

Contact Info

Product

Resources

About