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Cited by 80 publications
(45 citation statements)
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“…Thus, their mutation both prevents cells death and results in unchecked proliferation signaling. For example, p53 suppresses tumorogenesis not only by activating arrest or apoptosis, but also by suppressing mTORC and ERK via up-regulating expression of their inhibitors, at least in certain tissues (Matthew et al 2009; Feng and Levine 2010; Hasty et al 2013; Drosten et al 2014; Akeno et al 2015). There are other examples of stress-activated pathways directly repressing proliferation signals: upon nutrient limitation in mouse embryonic fibroblasts, stress-activated AMPK and p38β suppress mTORC activity through at least three independent routes (Zheng et al 2011).…”
Section: Introductionmentioning
confidence: 99%
“…Thus, their mutation both prevents cells death and results in unchecked proliferation signaling. For example, p53 suppresses tumorogenesis not only by activating arrest or apoptosis, but also by suppressing mTORC and ERK via up-regulating expression of their inhibitors, at least in certain tissues (Matthew et al 2009; Feng and Levine 2010; Hasty et al 2013; Drosten et al 2014; Akeno et al 2015). There are other examples of stress-activated pathways directly repressing proliferation signals: upon nutrient limitation in mouse embryonic fibroblasts, stress-activated AMPK and p38β suppress mTORC activity through at least three independent routes (Zheng et al 2011).…”
Section: Introductionmentioning
confidence: 99%
“…p53 plays a central role in responding to DNA damage and inhibits mTOR pathway in stressed cells (18). p53 inhibits mTOR by activation of AMP-activated protein kinase (AMPK) and subsequent regulation of the TSC1/TSC2 complex (21).…”
mentioning
confidence: 99%
“…Inhibitors of the mTOR pathway have been ascribed anti-aging effects in mice, flies and worms. 21,35,62 One might wonder how much of these effects can be attributed to the aborted p53 response per se, this given the much debated role of p53 in mammalian aging. [63][64][65] It is in this context interesting to note that resveratrol, LY294.002, and curcumin promoted somatic cell reprogramming.…”
Section: Discussionmentioning
confidence: 99%
“…21 A better understanding of how mTOR and p53 pathways are connected is needed in order to improve the use of mTOR inhibitors in anti-cancer therapy. Here we investigated the outcomes of simultaneous inhibition of mTOR and activation of p53 by nucleolar stress.…”
Section: Discussionmentioning
confidence: 99%
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