MTHFR <i>C677T</i> and <i>A1298C</i> Gene Polymorphisms in Human Kidney Cancer Tissues

Abstract

Introductıon While kidney cancer is the third most common cancer among urogenital cancers, it ranks seventeen among the most common cancers (1). Although kidney cancer patients usually have good outcomes after surgical intervention, less than 20% of individuals with advanced disease have a 2-year survival. Kidney cancer is seen twice in men than in women (2). Kidney cancer is not a single type of cancer and it has genetically and histologically different types responding to therapy differently due to mutations in various genes (3). 5,10-methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in folate metabolism. MTHFR catalyzes the reduction of MTHF to 5-methyl THF using 5,10 FAD as a cofactor that acts as a regulator of folate coenzymes for purine, pyrimidine and methionine synthesis (4). Fivemethyl THF provides the methyl group for the synthesis of methionine (5)