mSLA-based 3D printing of acrylated epoxidized soybean oil - nano-hydroxyapatite composites for bone repair

Mondal, Dibakar; Haghpanah, Zahra; Huxman, Connor J.; Tanter, Sophie; Sun, Daofeng; Gorbet, Maud; Willett, Thomas L.

doi:10.1016/j.msec.2021.112456

Cited by 40 publications

(40 citation statements)

References 58 publications

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“…Four inks were prepared, and their compositions are summarized in Table 1. The composition of an AESO/PEGDA/nHA-based nanocomposite ink (SP10) reported earlier (Mondal et al, 2021) has been added to this table for comparison.…”

Section: Preparation Of Nanocomposite Inksmentioning

confidence: 99%

“…The rheological properties (viscosity and shear yield strength) and cure depth curve of the inks, and the composition and thermal degradation of the nanocomposite inks [assessed using thermogravimetric analysis (TGA)] were measured in accordance with protocols previously used by our research group (Mondal et al, 2021).…”

Section: Rheology Cure Depth and Thermogravimetric Analysis Of The Na...mentioning

confidence: 99%

“…The viscosity and shear yield strength values were calculated from the slopes and the y-axis intercept values of the shear stress vs shear rate curves and plotted in Figures 1C,D. Replacing AESO with mAESO decreased the viscosity from 490 mPa s (SP10) (Mondal et al, 2021) to 253 mPa s (IM0). The ink viscosities increased with increasing IM content.…”

Section: Rheology Cure Depth and Printability Of The Nanocomposite Inksmentioning

confidence: 99%

“…Masked stereolithography (mSLA) is a high-resolution additive manufacturing process where light-sensitive liquid resin is solidified (cured) via selective exposure to light [commonly ultraviolet (UV)] in a layer-by-layer process. Compared to other three-dimensional (3D) printing techniques, such as fused deposition modeling (FDM), direct ink writing (DIW), or stereolithography (SLA), mSLA printing methods are inexpensive and provide solid prints with minimal defects (Mondal et al, 2021;Muenks and Kyosev, 2021;Podgórski et al, 2021). It is a relatively fast printing technology as it prints each layer all at once by light/UV masking using an LCD screen, rather than point-by-point extrusion or curing (Mondal et al, 2021;Muenks and Kyosev, 2021;Podgórski et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Compared to other three-dimensional (3D) printing techniques, such as fused deposition modeling (FDM), direct ink writing (DIW), or stereolithography (SLA), mSLA printing methods are inexpensive and provide solid prints with minimal defects (Mondal et al, 2021;Muenks and Kyosev, 2021;Podgórski et al, 2021). It is a relatively fast printing technology as it prints each layer all at once by light/UV masking using an LCD screen, rather than point-by-point extrusion or curing (Mondal et al, 2021;Muenks and Kyosev, 2021;Podgórski et al, 2021). However, the selection and development of materials as inks for mSLA-based 3D printing is a technical challenge.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Mechanical Properties of 3D Printed Nanocomposites Composed of Functionalized Plant-Derived Biopolymers and Calcium-Deficient Hydroxyapatite Nanoparticles

2022

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The combination of plant-derived polymer resins and mineral-based nanoparticles into three dimensional (3D) printable, high-performance nanocomposites suggests a means to improve the sustainability profile of rapid prototyping and additive manufacturing. In this work, our previously published nanocomposite biomaterial system of acrylated epoxidized soybean oil (AESO) and polyethylene glycol (PEGDA) diluent composited with calcium-deficient hydroxyapatite (nHA) nanorods was improved by the substitution of AESO with methacrylated AESO (mAESO) and the partial substitution of PEGDA with isosorbide methacrylate (IM). mAESO was used to increase the degree of crosslinking and reduce the ink viscosity. IM was synthesized by reacting the hydroxyl groups on isosorbide with methacrylic anhydride. The effects of partially replacing PEGDA with IM on the rheology and printability of the nanocomposite inks and the mechanical properties of the resulting nanocomposite materials were quantified. These masked stereolithography (mSLA) printed nanocomposites have greatly improved mechanical properties (tensile strength, Young’s modulus, and Mode-I fracture toughness) due to the shift to mAESO and IM. IM greatly improved the tensile fracture strength and Young’s modulus of the nanocomposites by acting as a reactive diluent and as a stiff segment in the polymer system. Dynamic mechanical analysis revealed that the glass transition temperature of the nanocomposite increased due to the addition of IM. However, IM decreased the strain-at–fracture, making the nanocomposites more brittle. This study demonstrates the development of high-performance mAESO-IM-nHA-based novel nanocomposites that can be easily 3D printed using desktop mSLA, suggesting a facile path forward to improved sustainability in rapid prototyping and additive manufacturing using nanocomposites for a broad range of applications.

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Section: Preparation Of Nanocomposite Inksmentioning

confidence: 99%

Section: Rheology Cure Depth and Thermogravimetric Analysis Of The Na...mentioning

confidence: 99%

Section: Rheology Cure Depth and Printability Of The Nanocomposite Inksmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Enhanced Mechanical Properties of 3D Printed Nanocomposites Composed of Functionalized Plant-Derived Biopolymers and Calcium-Deficient Hydroxyapatite Nanoparticles

2022

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Vat Photopolymerization Additive Manufacturing Technology for Bone Tissue Engineering Applications

2022

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Additive manufacturing has transformed the perspective of producing three dimensions (3D) objects toward achieving high quality in terms of accuracy, resolution, and high mechanical integrity with excellent surface finishing in little time compared to subtractive (traditional) production. Vat photopolymerization (VPP) additive manufacturing is among the most common 3D printing technology used in the medical field, academic research, and industrial production of 3D parts. Four main 3D printing techniques fall under VPP, namely continuous liquid interface production (CLIP), daylight polymer printing (DPP), stereolithography (SLA), and digital light processing (DLP). The last two are the focus of the present article. The high accuracy, precision, the unique ability to produce highly complex porous structural geometries, the low printing cost, and the production time of 3D structures compared to subtractive 3D manufacturing make DLP and SLA suitable for medical applications, specifically in regenerative medicine. This review presents the recent trend of DLP and SLA as used in medical research related to bone tissue engineering highlighting the mechanical and biological properties of the resulting 3D bone structures. In addition, photopolymerization mechanisms, photocurable materials, and the working principles of DLP and SLA are introduced.

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The Effects of Shear Stress on the Micromechanical Properties of 3D Printable Biopolymer Nanocomposites Using a Custom‐Designed Extrusion‐Based 3D Printer

Hashemi,

Mondal,

Patil

et al. 2024

Adv Eng Mater

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Current advancements in 3D printing technology have the potential to facilitate the production of scaffolds and implants for various biomedical applications, including bone repair and regeneration. 3D printed patient‐specific bone‐inspired nanocomposite grafts might be a viable alternative to current bone repair treatment methods if they provide appropriate anatomic structure, biocompatibility, and adequate mechanical properties. In the current work, a 3D printable nanocomposite biomaterial ink with bone cell biocompatibility (in vitro) is printed while adjusting shear stress during extrusion using a custom‐designed 3D printer to investigate the shear stress effect on the mechanical properties of the 3D printed nanocomposite. Tensile test results, as well as polarized light microscopy and differential scanning calorimetry analyses, reveal that increasing the applied shear stress from 3.5 to 14 kPa during extrusion‐based 3D printing in a custom‐built 3D printer, increased the strength, tensile modulus, and toughness of printed nanocomposite filaments by about three‐fold. This improvement is attributed to increased crystallinity in the thermoset biopolymer matrix due to the higher shear stress and the nano‐confinement effect. This implies that greater shear during layer‐by‐layer extrusion‐based 3D printing might be employed to create more robust mechanically competent 3D printed nanocomposite bone grafts.

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mSLA-based 3D printing of acrylated epoxidized soybean oil - nano-hydroxyapatite composites for bone repair

Cited by 40 publications

References 58 publications

Enhanced Mechanical Properties of 3D Printed Nanocomposites Composed of Functionalized Plant-Derived Biopolymers and Calcium-Deficient Hydroxyapatite Nanoparticles

Enhanced Mechanical Properties of 3D Printed Nanocomposites Composed of Functionalized Plant-Derived Biopolymers and Calcium-Deficient Hydroxyapatite Nanoparticles

Vat Photopolymerization Additive Manufacturing Technology for Bone Tissue Engineering Applications

The Effects of Shear Stress on the Micromechanical Properties of 3D Printable Biopolymer Nanocomposites Using a Custom‐Designed Extrusion‐Based 3D Printer

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