2013
DOI: 10.1007/s10616-013-9655-2 View full text |Buy / Rent full text
|
|

Abstract: The purpose of this study was to test whether mesenchymal stem cells (MSCs) transplantation with application of granulocyte colony-stimulating factor (G-CSF) would have beneficial effects on damaged heart in a rabbit model of myocardial infarction (MI). MI was created by ligation of the left anterior descending coronary artery. After induction of MI, 40 New Zealand white rabbits were randomly divided into 8 groups: (1) MSCs injection at 3 days after MI; (2) G-CSF injection at 3 days after MI; (3) MSCs + G-CSF … Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
1
1
0
2
0

Year Published

2014
2014
2017
2017

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

0
2
0
Order By: Relevance
“…In clinics, G-CSF treatment resulted in a positive functional effect in stroke [ 37 39 ]. Furthermore, the combined local application therapy of G-CSF with MSCs has demonstrated augmented spinal cord regeneration [ 40 ], peripheral nerve regeneration [ 41 ], cerebral ischemia recovery [ 42 ], ulcerative colitis improvement [ 43 ], and myocardial infarction recovery [ 44 ] in experimental animal models. A case report has recently demonstrated neurological improvement of spinal cord injury using the combination therapy of G-CSF and autologous bone marrow stem cells [ 45 ].…”
Section: Discussionmentioning
“…After the heart was exposed through a lateral thoracotomy, a 6-0 polypropylene thread was passed around the left coronary artery and the artery was occluded. The ECG was recorded to confirm the presence of infarction (Yang et al 2013;Zeng et al 2010a, b).…”
Section: Myocardial Infarctionmentioning