Mp63-13 next-Generation Sequencing Reveals Genomic Differences Between Male and Female Patients With Urothelial Carcinoma

Abstract

for FAM81A (P < 0.0001), and 1.06 and 1.80 for PCSK6 (P < 0.0001), respectively. Univariate Cox proportional hazards regression analysis showed that gender (P [ 0.0082), urinary cytology (P [ 0.0300), and tumor grade (P [ 0.0151) had a significant effect on recurrence-free survival. In multivariate analyses, gender was an independent prognostic factor for recurrence-free survival (P [ 0.0356, risk ratio 2.95, 95% confidence interval 1.08-7.34). Univariate Cox proportional hazards regression analysis showed that FAM81A (P [ 0.0022), and PCSK6 (P [ 0.0147) copy number had a significant effect on progression-free survival. In multivariate analyses, FAM81A copy number was an independent prognostic factor for progression-free survival (P [ 0.0419, risk ratio 7.59, 95% confidence interval 1.07-153.42).CONCLUSIONS: These data suggest that FAM81A CNP is potentially a new tumor marker for predicting the efficacy of BCG therapy for NMIBC.