Mp080uromodulin Exerts Potent Preventive and Therapeutic Effects in Wky Rats With Antigbm Glomerulonephritis via Il6 Activation

Abstract

Introduction and Aims: Uromodulin (UMOD), also known as Tamm-Horsfall protein, is a kidney-specific protein expressed by epithelial cells lining the thick ascending limb of the loop of Henle. Although several reports have described the anti-inflammatory and immunomodulatory effects of UMOD, the effects on the kidney diseases remains unclear. In this study, the therapeutic effects of UMOD and its mechanism were examined in nephrotoxic serum nephritis (NTS-N) of Wistar Kyoto (WKY) rats. Methods: NTS-N was induced in WKY rats on day 0. In the preventive study, the groups of animals were administered either UMOD (WKY-UMOD) or vehicle (WKY-CON) just before NTS administration, then the rats were sacrificed on Day 4. In the therapeutic study, the treatment was started on Day 4, then the rats were sacrificed