Journal of Cell Biology volume 215, issue 6, P823-840 2016 DOI: 10.1083/jcb.201606092 View full text
|
|
Share
Tien-chen Lin, Annett Neuner, Dirk Flemming, Peng Liu, Takumi Chinen, Ursula Jäkle, Robert Arkowitz, Elmar Schiebel

Abstract: Cells use γ-tubulin complex to nucleate microtubules. The assembly of active microtubule nucleator is spatially and temporally regulated through the cell cycle. Lin et al. show that the protein Mzt1/MOZART1 and γ-tubulin complex receptors directly interact and act together to assemble the γ-tubulin small complex into an active microtubule nucleation template and that such interaction is conserved between Candida albicans and human cells.