Tien-chen Lin, Annett Neuner, Dirk Flemming, Peng Liu, Takumi Chinen, Ursula Jäkle, Robert Arkowitz, Elmar Schiebel
Abstract:Cells use γ-tubulin complex to nucleate microtubules. The assembly of active microtubule nucleator is spatially and temporally regulated through the cell cycle. Lin et al. show that the protein Mzt1/MOZART1 and γ-tubulin complex receptors directly interact and act together to assemble the γ-tubulin small complex into an active microtubule nucleation template and that such interaction is conserved between Candida albicans and human cells.
scite is a Brooklyn-based startup that helps researchers better discover and evaluate scientific articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by researchers from dozens of countries and is funded in part by the National Science Foundation and the National Institute of Drug Abuse of the National Institutes of Health.