Moyamoya Disease Is Associated With Endothelial Activity Detected by Anti-Nestin Antibody

Chmelová, Jana; Kolář, Zdeněk; Procházka, Václav; Curík, R; Dvořáčková, Jana; Sirucek, Pavel; Kraft, Otakar; Hrbac, Tomas

doi:10.5507/bp.2010.024

Cited by 18 publications

(15 citation statements)

References 15 publications

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“…17 It is well known that strong contrast enhancement of the arterial wall suggests an increase in the vascular supply and increased endothelial permeability, which promotes entry of the contrast agent into the extravascular space. 18 Chmelova et al 19 found a higher expression of both angiogenetic factors in intima and vascular endothelial growth factor in the endothelium of Moyamoya-affected arteries than normal arteries. Nestin, a marker of newly formed endothelial cells was expressed in the Moyamoya-affected vessels.…”

Section: Discussionmentioning

confidence: 99%

“…20 Thus, it can be presumed that an active angiogenetic milieu prevails in the enhanced vessels in patients with MMD. 19 Similar to the atherosclerotic process in the extracranial vessels where concentric and circumferential wall enhancements suggest an inflammatory response due to increased macrophage infiltration and neovascularity, the enhancement in Moyamoya vessels may be considered to represent an active angiogenetic process and inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

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Vessel Wall Thickening and Enhancement in High-Resolution Intracranial Vessel Wall Imaging: A Predictor of Future Ischemic Events in Moyamoya Disease

Kathuveetil¹,

Sylaja²,

Senthilvelan

et al. 2020

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Very few data are available with regard to high-resolution intracranial vessel wall imaging characteristics of Moyamoya disease and their relation to ischemic stroke risk. We investigated the high resolution imaging characteristics of MMD and its correlation with recent ischemic events. MATERIALS AND METHODS:Patients with Moyamoya disease confirmed by DSA, including patients after revascularization, were enrolled. All the patients underwent high-resolution intracranial vessel wall imaging. Vessel wall thickening, enhancement, and the remodeling index of the bilateral distal ICA and proximal MCA were noted. The patients were followed up at 3 months and 6 months after high-resolution intracranial vessel wall imaging and the association of ischemic events with imaging characteristics was assessed. RESULTS:Twenty-nine patients with Moyamoya disease were enrolled. The median age at symptom onset was 12 years (range, 1-51 years). A total of 166 steno-occlusive lesions were detected by high-resolution intracranial vessel wall imaging. Eleven lesions with concentric wall thickening (6.6%) were noted in 9 patients. Ten concentric contrast-enhancing lesions were observed in 8 patients, of which 3 patients (4 lesions) showed grade II enhancement. The presence of contrast enhancement (P 4 .01) and wall thickening (P # .001) showed a statistically significant association with ischemic events within 3 months before and after the vessel wall imaging. Grade II enhancement showed a statistically significant (P 4 .02) association with ischemic events within 4 weeks of high-resolution intracranial vessel wall imaging. The mean 6 standard deviation outer diameter of the distal ICA (right, À3.3 6 0.68 mm; left, 3.4 6 0.60 mm) and the remodeling index (right, 0.71 6 0.13; left, 0.69 6 0.13) were lower in Moyamoya disease. CONCLUSIONS:High-resolution intracranial vessel wall imaging characteristics of concentric wall thickening and enhancement are relatively rare in our cohort of patients with Moyamoya disease. The presence of wall thickening and enhancement may predict future ischemic events in patients with Moyamoya disease. ABBREVIATIONS: ACA 4 anterior cerebral artery; HRVWI 4 high-resolution intracranial vessel wall imaging; MMD 4 Moyamoya disease; PCA 4 posterior cerebral artery; SD 4 standard deviation Indicates open access to non-subscribers at www.ajnr.org http://dx.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Vessel Wall Thickening and Enhancement in High-Resolution Intracranial Vessel Wall Imaging: A Predictor of Future Ischemic Events in Moyamoya Disease

Kathuveetil¹,

Sylaja²,

Senthilvelan

et al. 2020

AJNR Am J Neuroradiol

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“…Disappearance of the moyamoya (disappearance of the moyamoya vessels, with cerebral blood flow derived only from the external carotid artery and the vertebrobasilar artery systems) endothelial cells (48), and that the endometrial thickening caused by fibrous cell hyperplasia of the arterial intima is the cause of arterial stenosis and occlusion (3). Guo et al (49) reported that arterial stenosis and occlusion of familial MMD may be due to smooth muscle tissue hyperplasia associated with a mutation in the actin, α2, smooth muscle, aorta gene.…”

Section: Pathology Of MMDmentioning

confidence: 99%

Epidemiology, diagnosis and treatment of moyamoya disease (Review)

2019

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Moyamoya disease (MMD) is a type of chronic cerebrovascular occlusion disease, which frequently occurs in East Asian populations, including pediatric and adult patients, and may lead to ischemic or hemorrhagic stroke, headache, epilepsy or transient ischemic attack. To date, the underlying mechanisms of MMD have remained to be fully elucidated, but certain studies have indicated that genetic factors may be an important component of its development. Cerebral angiography is the best approach for diagnosing MMD. However, with technological advances, non-invasive techniques are increasingly used to accurately evaluate MMD. MMD is commonly treated via surgery, and an increasing number of patients are benefitting from the intra-and extra-cranial revascularization. The present article provides a comprehensive review of MMD on the basis of previous research.

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“…Chmelova et al . found that angiogenetic factors in intima and VEGF in the endothelium of moyamoya-affected arteries were higher expressed than normal17. This suggests an active angiogenetic process in the enhanced vessel wall in patients with MMV.…”

Section: Discussionmentioning

confidence: 92%

The Contrast Enhancement of Intracranial Arterial Wall on High-resolution MRI and Its Clinical Relevance in Patients with Moyamoya Vasculopathy

Wang

Yang

Zhou

et al. 2017

Sci Rep

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The purpose of this study is to investigate the characteristics of intracranial vessel wall enhancement and its relationship with ischemic infarction in patients with Moyamoya vasculopathy (MMV). Forty-seven patients with MMV confirmed by angiography were enrolled in this study. The vessel wall enhancement of the distal internal carotid artery, anterior cerebral artery and middle cerebral artery was classified into eccentric and concentric patterns, as well as divided into three grades: grade 0, grade 1 and grade 2. The relationship between ischemic infarction and vessel wall enhancement was also determined. Fifty-six enhanced lesions were found in patients with (n = 25) and without acute infarction (n = 22). The incidence of lesions with grade 2 enhancement in patients with acute infarction was greater than that in those without acute infarction (p = 0.011). In addition, grade 2 enhancement of the intracranial vessel wall was significantly associated with acute ischemic infarction (Odds ratio, 26.7; 95% confidence interval: 2.8–258.2; p = 0.005). Higher-grade enhancement of the intracranial vessel wall is independently associated with acute ischemic infarction in patients with MMV. The characteristics of intracranial vessel wall enhancement may serve as a marker of its stability and provide important insight into ischemic stroke risk factors.

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Moyamoya Disease Is Associated With Endothelial Activity Detected by Anti-Nestin Antibody

Cited by 18 publications

References 15 publications

Vessel Wall Thickening and Enhancement in High-Resolution Intracranial Vessel Wall Imaging: A Predictor of Future Ischemic Events in Moyamoya Disease

Vessel Wall Thickening and Enhancement in High-Resolution Intracranial Vessel Wall Imaging: A Predictor of Future Ischemic Events in Moyamoya Disease

Epidemiology, diagnosis and treatment of moyamoya disease (Review)

The Contrast Enhancement of Intracranial Arterial Wall on High-resolution MRI and Its Clinical Relevance in Patients with Moyamoya Vasculopathy

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