Moving-mask Lithography for 3D Microstructure Molding

Kato, Nobuhiro; Kai, Takahisa; Hirano, Masakazu

doi:10.2494/photopolymer.27.85

Cited by 2 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 b). Following post-exposure bake, development, rinse, and drying with nitrogen blow, a master mold of the microneedle was obtained 5 , 6 . The shape of the master mold was transferred by poly-dimethyl siloxane (PDMS) (Sylgard 184, Dow Corning Corp, Midland, MI, USA) to be a female mold (Fig.…”

Section: Resultsmentioning

confidence: 99%

A biodegradable microneedle sheet for intracorporeal topical hemostasis

Yokoyama

Chihara

Tanaka

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

Management of bleeding is critical for improving patient outcomes. While various hemostatic products are used in daily practice, technical improvement is still needed. To addresses this problem, we newly developed a microneedle hemostatic sheet based on microneedle technology. We demonstrated the unique features of this microneedle hemostatic sheet, including reduced hemostatic time, biodegradable polymer composition that allows intracorporeal use without increasing infectious risk incorporation of microneedles to fix the sheet to the wound even on the left ventricular wall of a swine while beating, and a mesh structure with flexibility comparable to that of bonding surgical tape and sufficient rigidity to penetrate human aorta tissue and swine left ventricular wall. One potential application of the microneedle hemostatic sheet is intracorporeal topical hemostasis for parenchymatous organs, large vessels, and heart wall during trauma or surgery, in addition to new, widespread applications.

show abstract

Section: Resultsmentioning

confidence: 99%

A biodegradable microneedle sheet for intracorporeal topical hemostasis

Yokoyama

Chihara

Tanaka

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Master male molds of microneedles were fabricated by backside exposure using a previously reported moving-mask lithography system [12]. A custom-made soda lime glass wafer (50 mm in diameter, 170 μm in thickness; Matsunami Glass Ind., Ltd.) was spin-coated with a negative-tone photoresist (SU-8 3050; MicroChem) using a spin-coater (1H-D7; Mikasa Co., Ltd).…”

Section: Fabrication Of Master Male Moldmentioning

confidence: 99%

Development of a Rapid Prototyping System for Microneedles Using Moving-mask Lithography with Backside Exposure

Kai

Mori

Kato

2016

ABE

Self Cite

View full text Add to dashboard Cite

Moving-mask lithography with backside exposure was utilized to generate master male mold for biodegradable polymer microneedle production. The microneedle shape was calculated from the exposure dose, mask geometry, and moving trajectory using a newly developed computer simulation. Two conditions (90 µm aperture with 80 µm diameter of circular movement, and 90 µm aperture with 90 µm diameter of circular movement) were selected to evaluate the moving-mask exposure effectiveness. By changing the moving trajectory, two different sizes of microneedles were obtained from a single-size aperture mask. The fabricated microneedle and calculated microneedle geometry showed good qualitative agreement. The geometrical difference was 2% in basal diameter and 8%-16% in height. Using the master male mold, biodegradable polymer microneedles made of chondroitin sulfate C sodium salt (CSC) were fabricated by casting from a poly-dimethylsiloxane female mold. The shape of the biodegradable CSC microneedles showed good agreement with the master male mold.

show abstract

Moving-mask Lithography for 3D Microstructure Molding

Cited by 2 publications

References 17 publications

A biodegradable microneedle sheet for intracorporeal topical hemostasis

A biodegradable microneedle sheet for intracorporeal topical hemostasis

Development of a Rapid Prototyping System for Microneedles Using Moving-mask Lithography with Backside Exposure

Contact Info

Product

Resources

About