Movement Disorders and the Gut: A Review

Talman, Lauren S.; Pfeiffer, Ronald F.

doi:10.1002/mdc3.13407

Cited by 4 publications

(1 citation statement)

References 118 publications

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“…Gut microbiotic changes that play a crucial role in the bidirectional communication between the gut and the brain (Klann et al 2022 ) with a close link between multiple movement disorders and gastrointestinal dysfunction (Talman and Pfeiffer 2022 ), suggest that the gut microbes may shape neuronal development, modulate neurotransmission and affect behavior, have been associated with the pathomechanism of DPD (Dogra et al 2022 ; Mendonça et al 2020 ; Moustafa et al 2021 ; Socala et al 2021 ) (Felice et al 2016 ; Jones et al 2021 ; Tan et al 2022 ; Xie et al 2022 ). There is increasing evidence for the highly complex relationship between the gut and the brain in PD, including the potential role of the vagus nerve, αSyn deposition in the enteric nervous system, related to intestinal permeability, autonomic dysfunction, inflammation, neural immune system and the gut microbiome (Nowak et al 2022 ; Tan et al 2022 ; Tansey et al 2022 ; Warnecke et al 2022 ).…”

Section: The Gut-brain Axismentioning

confidence: 99%

The pathobiological basis of depression in Parkinson disease: challenges and outlooks

Ka¹

2022

J Neural Transm

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Depression, with an estimated prevalence of about 40% is a most common neuropsychiatric disorder in Parkinson disease (PD), with a negative impact on quality of life, cognitive impairment and functional disability, yet the underlying neurobiology is poorly understood. Depression in PD (DPD), one of its most common non-motor symptoms, can precede the onset of motor symptoms but can occur at any stage of the disease. Although its diagnosis is based on standard criteria, due to overlap with other symptoms related to PD or to side effects of treatment, depression is frequently underdiagnosed and undertreated. DPD has been related to a variety of pathogenic mechanisms associated with the underlying neurodegenerative process, in particular dysfunction of neurotransmitter systems (dopaminergic, serotonergic and noradrenergic), as well as to disturbances of cortico-limbic, striato-thalamic-prefrontal, mediotemporal-limbic networks, with disruption in the topological organization of functional mood-related, motor and other essential brain network connections due to alterations in the blood–oxygen-level-dependent (BOLD) fluctuations in multiple brain areas. Other hypothetic mechanisms involve neuroinflammation, neuroimmune dysregulation, stress hormones, neurotrophic, toxic or metabolic factors. The pathophysiology and pathogenesis of DPD are multifactorial and complex, and its interactions with genetic factors, age-related changes, cognitive disposition and other co-morbidities awaits further elucidation.

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Section: The Gut-brain Axismentioning

confidence: 99%

The pathobiological basis of depression in Parkinson disease: challenges and outlooks

Ka¹

2022

J Neural Transm

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Gastrointestinal Dysfunction in Genetically Defined Neurodevelopmental Disorders

Davidson,

Holingue,

Jimenez-Gomez

et al. 2023

Semin Neurol

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Gastrointestinal symptoms are common in most forms of neurodevelopment disorders (NDDs) such as in autism spectrum disorders (ASD). The current patient-reported outcome measures with validated questionnaires used in the general population of children without NDDS cannot be used in the autistic individuals. We explore here the multifactorial pathophysiology of ASD and the role of genetics and the environment in this disease spectrum and focus instead on possible diagnostics that could provide future objective insight into the connection of the gut-brain-microbiome in this disease entity. We provide our own data from both humans and a zebrafish model of ASD called Phelan-McDermid Syndrome. We hope that this review highlights the gaps in our current knowledge on many of these profound NDDs and that it provides a future framework upon which clinicians and researchers can build and network with other interested multidisciplinary specialties.

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Elucidating the role of diet in maintaining gut health to reduce the risk of obesity, cardiovascular and other age-related inflammatory diseases: recent challenges and future recommendations

Aziz,

Hussain,

Hameed

et al. 2024

Gut Microbes

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A healthy balanced diet is crucial in protecting the immune system against infections and diseases. Poor diets, such as the Western diet, contribute to the development of metabolic diseases, hypertension, and obesity. Microbiota, primarily composed of different microorganisms and residing in the gastrointestinal tract (GIT), also play a significant role in maintaining gut health. Polyphenols and probiotics found in fruits, vegetables, whole grains, legumes, nuts, and seeds promote gut health and support the growth of beneficial bacteria. Different types of diets, their categories, and their impact on health are also mentioned. The relationship between diet, gut health, and the risk of developing obesity, cardiovascular diseases, and inflammatory diseases is discussed in this review article. The rationale behind the review concludes future recommendations for maintaining gut health and reducing the occurrence of obesity, cardiometabolic diseases, and other inflammatory diseases. There is also the need for standardized research methods, long-term studies, and translating scientific knowledge into practical dietary recommendations.

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Movement Disorders and the Gut: A Review

Cited by 4 publications

References 118 publications

The pathobiological basis of depression in Parkinson disease: challenges and outlooks

The pathobiological basis of depression in Parkinson disease: challenges and outlooks

Gastrointestinal Dysfunction in Genetically Defined Neurodevelopmental Disorders

Elucidating the role of diet in maintaining gut health to reduce the risk of obesity, cardiovascular and other age-related inflammatory diseases: recent challenges and future recommendations

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