Movement cueing and motor execution in patients with dystonia: A kinematic study

Currà, Antonio; Berardelli, A.; Agostino, Rocco; Giovannelli, Morena; Koch, Giacomo; Manfredi, M.

doi:10.1002/1531-8257(200001)15:1<103::aid-mds1016>3.0.co;2-3

Cited by 51 publications

(32 citation statements)

References 53 publications

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“…Previous work has identified that dystonic patients are slow when performing voluntary movements [5][6][7][8][9][10]. We have extended this finding to include slowness in isometric force production at the wrist (a clinically involved joint) and the elbow (a joint that did not present with overt clinical symptoms of dystonia).…”

Section: Discussionmentioning

confidence: 77%

“…For example, patients with writer's cramp have been shown to have an average strength deficit of approximately 20% at the wrist and elbow joints of the clinically involved arm compared to healthy subjects [4]. Dystonic patients have also been shown to be slow at the wrist [5] and elbow joints [6] during single degree of freedom movement and during whole arm movement [7][8][9][10]. These deficits have been shown to be associated with decreased muscle activity and could not be explained by co-contraction of antagonist muscles [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Based on previous studies, which examined slowness of movement in patients with dystonia when movements are initiated from a resting state [5][6][7]9,10], we expected that hypothesis one would be supported and that patients would be slower than controls turning on force quickly from rest. It is not known however if this impairment remains or is exacerbated when the requirement for increased force output is superimposed on pre-activated muscle.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Rate of force production and relaxation is impaired in patients with focal hand dystonia

Prodoehl

MacKinnon

Comella

et al. 2006

Parkinsonism & Related Disorders

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One factor, which may contribute to slowed movement in dystonia, is impairment in controlling the voluntary rate of motor output. This study examined the ability of patients with focal hand dystonia to rapidly turn force on and off at the wrist and elbow joints. Dystonic patients were slower than controls in rapidly turning on force from rest at both joints, passively relaxing force and rapidly reversing force output from a steady-state flexion contraction. Adding a preload did not improve the ability of dystonic subjects to rapidly turn on force. These results support the idea that dystonia is a disorder of impaired motor cortical activation, possibly due to basal ganglia dysfunction.

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Rate of force production and relaxation is impaired in patients with focal hand dystonia

Prodoehl

MacKinnon

Comella

et al. 2006

Parkinsonism & Related Disorders

View full text Add to dashboard Cite

show abstract

“…The onset was defined as an increase of the velocity of the wrist above 0.05 m/sec. 26 The following period was called the acceleration period and lasted until the peak velocity was reached. The subsequent period was called the deceleration period and lasted until the wrist velocity was less than 0.05 m/sec.…”

Section: Periods Of the Reach-to-grasp Movementmentioning

confidence: 99%

Kinetic tremor in a reach-to-grasp movement in Parkinson's disease

et al. 2000

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“…The role played by the lateral prefrontal and posterior parietal cortices is in contrast to that played by the inferior parietal (Buxbaum et al 2003), SMA (Lu et al 2012) and pre-SMA (Cunnington et al 2002) cortices, as well as that played by the sub-cortical circuitry, particularly the basal ganglia (Currà et al 2000;François-Brosseau et al 2009). An important role in motor preparation is played by M1, which is activated milliseconds before the start of the movement (pre-movement component of M1) in both SI (Chen et al 1998) and ET tasks (Pascual-Leone et al 1992).…”

Section: Introductionmentioning

confidence: 95%

Influence of rTMS over the left primary motor cortex on initiation and performance of a simple movement executed with the contralateral arm in healthy volunteers

et al. 2012

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Repetitive transcranial magnetic stimulation (rTMS) affects cortical excitability according to the frequency of stimulation. Few data are available on the influence of rTMS applied over the primary motor cortex (M1) on motor performances in healthy volunteers. The aim of this study was to determine, through kinematic analysis, whether rTMS over the left M1 changes initiation and performance of movement executed with the contralateral arm. Nine healthy males completed a set of motor tasks, consisting of a single-joint rapid movement between two objects performed under three different behavioral conditions (self-initiated; externally triggered known, during which the subject could see where the target was positioned in advance; externally triggered unknown, during which the subject could not see where the target was positioned until he reached it). The tasks were performed in a randomized order in three different sessions, with a seven-day interval between each session: (1) without stimulation (baseline); (2) immediately after 1-Hz rTMS; (3) immediately after 10-Hz rTMS. We measured reaction time, movement time, calculated as the sum of the time taken to reach the target from movement onset (T1) and that taken to reach the target to movement termination (T2), acceleration and deceleration time on the velocity profile, as well as the ratio between them, and maximum speed and maximum acceleration. Reaction time, movement time, and T2 significantly increased after 1-Hz rTMS and decreased after 10-Hz rTMS, while the other parameters remained unchanged. Our results suggest that rTMS may modify both initiation and performance of a voluntary movement.

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Movement cueing and motor execution in patients with dystonia: A kinematic study

Cited by 51 publications

References 53 publications

Rate of force production and relaxation is impaired in patients with focal hand dystonia

Rate of force production and relaxation is impaired in patients with focal hand dystonia

Kinetic tremor in a reach-to-grasp movement in Parkinson's disease

Influence of rTMS over the left primary motor cortex on initiation and performance of a simple movement executed with the contralateral arm in healthy volunteers

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