2015
DOI: 10.1177/1933719115576727
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Abstract: This study was undertaken to investigate stem cells in adult mouse ovary, the effect of chemotherapy on them and their potential to differentiate into germ cells. Very small embryonic-like stem cells (VSELs) that were SCA-1þ/LinÀ/CD45À, positive for nuclear octamer-binding transforming factor 4 (OCT-4), Nanog, and cell surface stage-specific embryonic antigen 1, were identified in adult mouse ovary. Chemotherapy resulted in complete loss of follicular reserve and cytoplasmic OCT-4 positive progenitors (ovarian… Show more

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Cited by 77 publications
(103 citation statements)
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“…In the last years, researches have provided evidences for the existence of female germ line cells in the ovaries of mice (Johnson et al., ; Kerr et al., ; Pacchiarotti et al., ; Sriraman, Bhartiya, Anand, & Bhutda, ; Zhang et al., ; Zou et al., ) as well as in other species, including human (Bukovsky, Svetlikova, & Caudle, ; Parte et al., ; White et al., ) and bovine (Dunplop, Telfer, & Anderson, ). Post‐natal oogenesis was also reported in mice (Garg & Sinclair, ; Johnson et al., ; Pan et al., ; Virant, ).…”
Section: Introductionmentioning
confidence: 99%
“…In the last years, researches have provided evidences for the existence of female germ line cells in the ovaries of mice (Johnson et al., ; Kerr et al., ; Pacchiarotti et al., ; Sriraman, Bhartiya, Anand, & Bhutda, ; Zhang et al., ; Zou et al., ) as well as in other species, including human (Bukovsky, Svetlikova, & Caudle, ; Parte et al., ; White et al., ) and bovine (Dunplop, Telfer, & Anderson, ). Post‐natal oogenesis was also reported in mice (Garg & Sinclair, ; Johnson et al., ; Pan et al., ; Virant, ).…”
Section: Introductionmentioning
confidence: 99%
“…VSELs survive oncotherapy in both mice (15,18) and human (21) gonads because of their quiescent nature whereas OSCs/SSCs and germ cells get destroyed since oncotherapy basically targets actively dividing cells. They are also reported in non-functional human gonads (13,20).…”
Section: Commentarymentioning
confidence: 99%
“…Based on their ontogeny, VSELs are relatively more mature developmentally as well as epigenetically compared to ES cells and thus spontaneously differentiate into sperm (12) and eggs (13)(14)(15) in vitro. Similarly we have reported that VSELs spontaneously regenerate adult mouse pancreas after partial pancreatectomy (16).…”
Section: Commentarymentioning
confidence: 99%
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“…More clarity is needed to define stem cells and distinguish them from the progenitors in the body organs16. VSELs survive oncotherapy in mammalian testis17, ovary18 and also in the BM19 and could possibly result in spontaneous pregnancies. Regenerative potential of VSELs has been reported in mice for lung epithelium20; cardiac tissue2122; neurons23; pancreas2425; liver26; and in humans for critical limb ischaemia27; cardiac tissue2829; and diabetes30.…”
mentioning
confidence: 99%