Mouse Models of Human Neurodegenerative Disorders

MicroRNA-574 is involved in cognitive impairment in 5-month-old APP/PS1 mice through regulation of neuritin

“…An important finding revealed by the current study is that 5-month-old APP/PS1 mice displayed a significant synaptic loss and cognitive deficits. APP/PS1 double transgenic mice as the animal model, which has similarity feature with AD development process (Frick et al, 2003;Bloom et al, 2005;Mucke et al, 2000). At the present study, we focused on the early stage of AD, and took 5-month-old APP/PS1 mice as model.…”

Role of Myo-Inositol by Magnetic Resonance Spectroscopy in Early Diagnosis of Alzheimer’s Disease in APP/PS1 Transgenic Mice

“…The study group included 30 tg mice (19 male and 11 female), and the control group used 20 wild-type (wt, 9 male and 11 female) mice born in the same nest. According to the report [16] , the first plaques in the cortex and hippocampus of APP/PS1 tg mice could be detected at 4-6 months, and Bell and Claudio Cuello [17] thought that 8-monthold APP/PS mice represented an early stage of amyloid pathology. Therefore, mice of 3, 5, and 8 months of age were used for the experiment.…”

Magnetic resonance microscopy of spinal cord injury in mouse using a miniaturized implantable RF coil

“…According to the current trend, however, the focus is shifting from rat to paraplegic murine models because of the availability of genetically engineered transgenic and mutant mouse strains along with molecular tools (Guertin, 2005;Rosenzweig and McDonald, 2004;Steward et al, 1999). The growing number of such efforts is likely to produce new targets for therapeutic strategies aimed at promoting neuronal protection, reorganization and functional recovery following SCI in humans (Bloom et al, 2005).…”