Biochemical Pharmacology volume 82, issue 2, P175-183 2011 DOI: 10.1016/j.bcp.2011.04.006 View full text
Gaiping Wen, Hagen Kühne, Christine Rauer, Robert Ringseis, Klaus Eder

Abstract: Convincing evidence from studies with peroxisome proliferator-activated receptor (PPAR)α-deficient mice suggested that the carnitine biosynthetic enzyme γ-butyrobetaine dioxygenase (BBD) is regulated by PPARα. However, the identification of BBD as a direct PPARα target gene as well as its exact regulation remained to be demonstrated. In silico-analysis of the mouse BBD promoter revealed seven putative peroxisome proliferator response elements (PPRE) with high similarity to the consensus PPRE. Luciferase report…

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