Mouse allergens in urban elementary schools and homes of children with asthma

Sheehan, William J.; Rangsithienchai, Pitud A.; Muilenberg, Michael L.; Rogers, Christine A.; Lane, Jeffrey P.; Ghaemghami, Jalal; Rivard, Donald V.; Otsu, Kanao; Hoffman, Elaine; Israel, Elliot; Gold, Diane R.; Phipatanakul, Wanda

doi:10.1016/s1081-1206(10)60242-6

Cited by 63 publications

(73 citation statements)

References 30 publications

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“…The School Inner-City Asthma Study (SICAS), is a prospective, NIAID funded, comprehensive study of classroom and school specific exposures and asthma morbidity among students in urban schools 25 . This study has consistently found much higher levels of mouse allergen in schools, compared to the same students’ home environments 21, 23 , with levels similar to those seen in occupational lab animal settings 33 . School cat and dog allergen levels in this same study were variable 21 , and not at levels previously shown to worsen symptoms 34 .…”

Section: Exposures In the School Environmentsupporting

confidence: 66%

“…Each of these areas may harbor different exposures to varying levels, and ideally should be assessed independently 12, 20, 23 . The conditions of each room should be considered with attention to the condition of every measurable feature, including the walls, ceilings, windows, floors, and presence of animals both domestic and pest 25 .…”

Section: School-based Environmental Assessments and Interventionsmentioning

confidence: 99%

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Introducing an environmental assessment and intervention program in inner-city schools

Huffaker

Phipatanakul

2014

Journal of Allergy and Clinical Immunology

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Home-based environmental interventions have demonstrated clinical benefit for children with asthma. Although much is known about school-based exposures, few studies have comprehensively examined the role the school environment plays in asthma and how effectively changing the environment may reduce morbidity, when adjusting for exposures in the home. This review summarizes the importance and common challenges of school-based environmental assessment and intervention studies linked to health effects. We focus on the key components of study development and the challenges and benefits to implementation.

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Section: Exposures In the School Environmentsupporting

confidence: 66%

Section: School-based Environmental Assessments and Interventionsmentioning

confidence: 99%

Introducing an environmental assessment and intervention program in inner-city schools

Huffaker

Phipatanakul

2014

Journal of Allergy and Clinical Immunology

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“…Mouse allergen levels vary by neighborhood [20]. Mouse allergen is also detected in school and daycare settings, with prevalence rates refl ecting the prevalence rates in US homes [21][22][23].…”

Section: Distribution and Predictors Of Exposurementioning

confidence: 99%

Role of mouse allergens in allergic disease

Matsui

2009

Curr Allergy Asthma Rep

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Mouse allergen has long been recognized as an important cause of occupational allergy and asthma, but only recently has it been implicated in asthma and allergic diseases in community settings. Recent studies have established that mouse allergen is detectable in most US homes, with strikingly high levels in some inner cities. Inner city homes in major northeastern and midwestern US urban centers have levels as much as 100-fold higher than those found in other geographic regions. In addition, about 25% of inner city children with asthma have evidence of IgE sensitization to mouse. Several studies have shown that the combination of sensitization and exposure to higher levels of mouse allergen is associated with substantial asthma morbidity, including hospitalizations. Integrated pest management is efficacious in reducing mouse allergen levels and is recommended for sensitized patients with asthma. However, its impact on clinical outcomes has not yet been proven.

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“…Focusing only on the homes of inner-city children ignores the potential role of indoor school exposures on asthma severity. Pertinent allergens have been identified in inner-city schools [54][55][56][57][58]. Further still, there have been observations suggesting that exposure to allergens at schools is associated with worse asthma morbidity [59].…”

Section: Environmental Exposures In Inner-city Schools: the Second Homementioning

confidence: 99%

Inner-city asthma

Dutmer

McGraw²,

Liu³

2016

Current Opinion in Allergy &Amp; Clinical Immunology

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Challenging previously conceived exposure-disease relationships, recent literature has elucidated new avenues in the complex interplay between immunologically active exposures and their effects on inner-city asthma. These findings, and improved understanding of other relevant exposures, could steer the direction of primary (and secondary) disease prevention research. Moreover, careful identification of asthma characteristics has effectively established predictors of exacerbations, highlighting individuals for which additional therapies are warranted and for whom such treatments are most likely to be effective.

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Mouse allergens in urban elementary schools and homes of children with asthma

Cited by 63 publications

References 30 publications

Introducing an environmental assessment and intervention program in inner-city schools

Introducing an environmental assessment and intervention program in inner-city schools

Role of mouse allergens in allergic disease

Inner-city asthma

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