Motor nuclear involvement in progressive supranuclear palsy

Ishino, Hiroshi; Higashi, Hisato; Kuroda, Shigetoshi; Yabuki, S; Hayahara, Toshiyuki; Otsuki, Saburo

doi:10.1016/0022-510x(74)90248-2

Cited by 39 publications

(22 citation statements)

References 10 publications

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“… 1 the presence of NFTs in the two examined spinal cords was briefly described. Loss of neurons in the anterior horn 7–10,12,13 and the presence of NFTs in the spinal cord have been described 1,7,11,14 . Kato et al.…”

Section: Discussionmentioning

confidence: 99%

“…In the original PSP report by Steele et al 1 the presence of NFTs in the two examined spinal cords was briefly described. Loss of neurons in the anterior horn [7][8][9][10]12,13 and the presence of NFTs in the spinal cord have been described. 1,7,11,14 Kato et al performed ultrastructural electron microscopy studies of NFTs in PSP spinal cords and reported that the NFTs consisted of bundles of straight fibrils with a diameter of approximately 15 nm 22 These NFTs were arranged in bundles of compact parallel arrays and were found to be essentially identical to the NFTs in the brain.…”

Section: Discussionmentioning

confidence: 99%

“…Although spinal cord abnormalities are generally considered uncommon in cases of PSP, 2 there have been some reports of spinal cord lesions in patients with PSP, and the morphologic changes have been described. 1,[7][8][9][10][11][12][13][14][15] Three notable studies were recently reported, [16][17][18] and the spinal cord is now considered to be one of the regions involved in PSP. In the present study, we systematically examined the spinal cords in 10 cases of PSP using the Gallyas-Braak (GB) impregnation technique 4,5 and AT-8 tau immunostaining, 19 paying particular attention to the tract degeneration and neuronal and glial tau pathology.…”

Section: Introductionmentioning

confidence: 99%

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Widespread spinal cord involvement in progressive supranuclear palsy

et al. 2007

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We describe the histopathologic features of spinal cord lesions in 10 cases of progressive supranuclear palsy (PSP) and review the literature. Histologic examination revealed atrophy with myelin pallor in the anterior funiculus and anterolateral funiculus in the cervical and thoracic segments in eight of the 10 cases, whereas the posterior funiculus was well preserved. The degrees of atrophy of the anterior funiculus and the anterolateral funiculus correlated with that of the tegmentum of the medulla oblongata. Myelin pallor of the lateral corticospinal tract was observed in two of the 10 cases. Microscopic observation of the spinal white matter, particularly the cervical segment, revealed a few to several neuropil threads, particularly in the white matter surrounding the anterior horn after Gallyas-Braak (GB) staining or AT-8 tau immunostaining. However, the posterior funiculus was completely preserved from the presence of argyrophilic or tau-positive structures. In the spinal gray matter, widespread distribution of neurons with cytoplasmic inclusions and neuropil threads was observed, particularly in the medial division of the anterior horn and intermediate gray matter, especially in the cervical segment. Globose-type neurofibrillary tangles and pretangles were found. The distribution of GB- or AT-8 tau-positive small neurons and neuropil threads resembled that of the spinal interneurons. In conclusion, the spinal cord, especially the cervical segment, is constantly involved in the pathologic process of PSP. We speculate that spinal interneurons and their neuronal processes, particularly in the medial division of the anterior horn and intermediate gray matter of the cervical segment, are most severely damaged in the PSP spinal cord.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Widespread spinal cord involvement in progressive supranuclear palsy

et al. 2007

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“…Areas with the most severe neuronal depletion show the largest number of tangles. Neuronal loss has been also described occasionally in the thalamus (David et al, 1968;Dalziel and Griffiths, 1977;Akashi ef al., 1989), pallidum (Weinmann, 1967;Ishino et al, 1974), nucleus basalis of Meynert (Tagliavini ef al., 1984), the pedunculopontine tegmental nucleus (Hirsch et al 1987), the rostra1 interstitial nucleus of the medial longitudinal fasciculus, nucleus of Darkshewitsch (Constantinidis et al., 1970;Davis et al, 1985) and the nucleus of Cajal, whereas the vestibular and oculomotor nuclei are relatively spared (Juncos el al. 1991).…”

Section: Neuronal Loss Neuronal Loss Is Generally Associatedmentioning

confidence: 99%

“…Lewy bodies have been described in the brainstem nuclei and the cerebral cortex in some PSP cases (Ishino et al, 1974;Gomori and Sima, 1984;Mori et al, 1986;D'Amato et al, 1991). Diffuse senile plaques (Sasaki et al, 1991) and swollen cortical neurons similar to those typical of corticobasal ganglionic degeneration have also been reported (Watts et al, 1994).…”

Section: Neuronal Loss Neuronal Loss Is Generally Associatedmentioning

confidence: 99%