Motor neuron disease and amyotrophic lateral sclerosis

Younger, David S.; Rowland, Lewis P.; Latov, N.; Sherman, William H.; Pesce, Michael A.; Lange, Dale J.; Trojaborg, W.; Miller, James R.; Lovelace, Robert E.; Hays, Arthur P.; Kim, T. S.

doi:10.1212/wnl.40.4.595

Cited by 113 publications

(39 citation statements)

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“…However, all medical records were scrutinized by a neurol ogist before the MND diagnosis was accepted. Some disorders clinically indistinguishable from classic MND are known, namely multi focal conduction block [27] with a monoclonal paraprotein [28] and MND with antibodies against the GM1 ganglioside [29]. In the future, several other subtypes of MND might be identified and the aetiology and pathogenesis might vary for the different subtypes.…”

Section: Discussionmentioning

confidence: 99%

An Epidemic-Like Cluster of Motor Neuron Disease in a Swedish County during the Period 1973–1984

et al. 1996

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We have tried to find all cases of motor neuron disease (MND) with onset during the study period 1961–1990 in the county of Skaraborg, Sweden, and in this retrospective study we have identified 168 cases, 107 men and 61 women. Fifty percent of them were alive 2 years after onset. The number of MND cases in consecutive 5-year intervals during the study period was shown to be statistically significantly elevated for males in the period 1981–1985 (Knox test disjoint procedure, p = 0.02). During the period 1973–1984, 70 males had onset of MND, corresponding to an average annual incidence of 4 per 100,000 person-years. This epidemic-like cluster was compared to the MND morbidity in a neighbouring county and was shown to be statistically significantly elevated even when the p value was adjusted for multiple comparisons. Agricultural work was significantly more common among the cases compared to the rest of the population.

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Section: Discussionmentioning

confidence: 99%

An Epidemic-Like Cluster of Motor Neuron Disease in a Swedish County during the Period 1973–1984

et al. 1996

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“…Third, in the 13 autopsy patients ([l, 2, 4-6, 10-12) [17], excluding the 3 patients with lymphoma in that series. bFrom Table 2.…”

Section: Pathogenesismentioning

confidence: 95%

Lymphoma, motor neuron diseases, and amyotrophic lateral sclerosis

Younger

Rowland

Latov

et al. 1991

Annals of Neurology

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112

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We studied 9 patients with motor neuron disease and lymphoma. The following several observations have not been recognized in the past: (1) Motor neuron syndromes are associated with either Hodgkin's disease or non-Hodgkin's lymphoma. (2) The syndromes are not restricted to lower motor neuron disorders; 8 of 9 patients had definite or probable upper motor neuron signs as well, qualifying for the diagnosis of amyotrophic lateral sclerosis. Corticospinal tracts were affected in both postmortem examinations. (3) The combination of motor neuron disease and lymphoma is often accompanied by paraproteinemia (3 of 7 patients studied), increased cerebrospinal fluid protein content (6 of 9 patients), and cerebrospinal fluid oligoclonal bands (3 of 9 patients). (4) In 2 patients, asymptomatic non-Hodgkin's lymphoma was found only because the discovery of paraproteinemia gave impetus to examine the bone marrow. (5) Patients with both upper and lower motor neuron signs (amyotrophic lateral sclerosis) may show physiological evidence of conduction block in peripheral nerves or autopsy abnormalities in peripheral nerves. The cause of this syndrome is not known. Both lymphoma and motor neuron disease could have a common cause, possibly a retroviral infection. The frequency of paraproteinemia suggests that an immunological disorder may play a role in the pathogenesis of the neurological disorder.

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“…34,43,84,109 -111,113,151-153 In addition to typical cases of amyotrophic lateral sclerosis, patients with subacute and chronic motor nerve disease have been described. [151][152][153] There have also been reports of multifocal motor neuropathy with antibodies directed at nerve gangliosides in patients with lymphoma, 96 and autopsy-proven amyotrophic lateral sclerosis with Waldenström's macroglobulinemia and antibodies to sulfated glucuronic acid paragloboside. 110 Among patients with HL or NHL and either classic amyotrophic lateral sclerosis or progressive spinal muscular atrophy, 94,111,[151][152][153] some have paraproteinemia and abnormally increased cerebrospinal fluid protein levels with oligoclonal bands.…”

Section: Clinical Presentationsmentioning

confidence: 99%

Lymphoma and peripheral neuropathy: A clinical review

2004

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Lymphoma occasionally affects the peripheral nervous system. When it does, the diagnosis can be elusive since many patients present without known lymphoma. Most peripheral nerve complications are due to non-Hodgkin's lymphoma (NHL), which infiltrates nerves causing axonal damage. This disorder can affect nerve roots and cranial nerves, often associated with lymphomatous meningitis. NHL may also infiltrate peripheral nerves and cause plexopathy, mononeuropathy, or generalized neuropathy. These neuropathies may resemble an asymmetric mononeuropathy multiplex or a generalized disorder such as chronic inflammatory demyelinating polyradiculoneuropathy. When NHL infiltrates diffusely, the term neurolymphomatosis is used. Hodgkin's lymphoma (HL), by contrast, rarely infiltrates nerves. More often, HL causes immunological disorders of the peripheral nervous system such as inflammatory plexopathy or Guillain-Barré syndrome. Other rare lymphomas such as intravascular lymphoma and Waldenstrom's macroglobulinemia can also affect peripheral nerves in specific ways. In addition, other malignant and nonmalignant lymphoproliferative disorders enter into the differential diagnosis of lymphomatous neuropathy. This review discusses the multiple peripheral nerve presentations of lymphoma from the clinician's point of view and provides a guide to the evaluation and diagnosis of these uncommon, challenging disorders.

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Motor neuron disease and amyotrophic lateral sclerosis

Cited by 113 publications

References 0 publications

An Epidemic-Like Cluster of Motor Neuron Disease in a Swedish County during the Period 1973–1984

An Epidemic-Like Cluster of Motor Neuron Disease in a Swedish County during the Period 1973–1984

Lymphoma, motor neuron diseases, and amyotrophic lateral sclerosis

Lymphoma and peripheral neuropathy: A clinical review

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