Motor cortex synchronization influences the rhythm of motor performance in premanifest huntington's disease

Casula, Elias Paolo; Mayer, Isabella; Desikan, M.; Tabrizi, Sarah J.; Rothwell, John C.; Orth, Michael

doi:10.1002/mds.27285

Cited by 32 publications

(22 citation statements)

References 52 publications

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“…Panel (b): Global cortical response is displayed in terms of TMS-evoked potentials (TEPs) recorded over all the scalp with the scalp voltage distribution at the three main peaks of activity (20-40 ms, 40-70 ms, and 70-150 ms)interhemispheric reduction of TMS-evoked activity was observable only when stimulating the UH, but not when stimulating the AH(Figure 1a). Spatiotemporal reconstruction of global TMS-evoked cortical activity(Figure 1b stroke patients; Figure 2b HC)revealed a wellknown sequence of positive and negative deflections lasting ≈250 ms, as usually observed after M1 stimulation(Casula et al, 2016;Casula, Mayer, et al, 2018;Casula, Rocchi, Hannah, & Rothwell, 2018). A first activation was focused over the stimulated M1 (20-40 ms) with an immediate spread over ipsilateral posterior areas (40-70 ms) and frontal areas (100 ms).…”

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confidence: 68%

Evidence for interhemispheric imbalance in stroke patients as revealed by combining transcranial magnetic stimulation and electroencephalography

Casula

Pellicciari

Bonnı̀

et al. 2021

Human Brain Mapping

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Interhemispheric interactions in stroke patients are frequently characterized by abnormalities, in terms of balance and inhibition. Previous results showed an impressive variability, mostly given to the instability of motor-evoked potentials when evoked from the affected hemisphere. We aim to find reliable interhemispheric measures in stroke patients with a not-evocable motor-evoked potential from the affected hemisphere, by combining transcranial magnetic stimulation (TMS) and electroencephalography. Ninteen stroke patients (seven females; 61.26 ± 9.8 years) were studied for 6 months after a first-ever stroke in the middle cerebral artery territory. Patients underwent four evaluations: clinical, cortical, corticospinal, and structural. To test the reliability of our measures, the evaluations were repeated after 3 weeks. To test the sensitivity, 14 age-matched healthy controls were compared to stroke patients. In stroke patients, stimulation of the affected hemisphere did not result in any inhibition onto the unaffected. The stimulation of the unaffected hemisphere revealed a preservation of the inhibition mechanism onto the affected. This resulted in a remarkable interhemispheric imbalance, whereas this mechanism was steadily symmetric in healthy controls. This result was stable when cortical evaluation was repeated after 3 weeks. Importantly, patients with a better recovery of the affected

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confidence: 68%

Evidence for interhemispheric imbalance in stroke patients as revealed by combining transcranial magnetic stimulation and electroencephalography

Casula

Pellicciari

Bonnı̀

et al. 2021

Human Brain Mapping

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“…Pattern of activation was similar, in terms of waveform and amplitude, between the stimulations of two hemispheres, with a strong reduction of activity in the hemisphere contralateral to the stimulation. Analysis of global TMS-evoked cortical activity (figure 1B)revealed a well-known sequence of positive and negative deflections lasting ≈250 ms, as usually observed after M1 stimulation(Casula et al, 2016;2018a;2018b). A first activation was focused over the stimulated M1 (20-40 ms) with an immediate spread over ipsilateral posterior areas and frontal areas (100 ms).…”

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confidence: 71%

Novel TMS-EEG indexes to investigate interhemispheric dynamics in humans

Casula

Maiella

Pellicciari

et al. 2020

Clinical Neurophysiology

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Objective: To validate two indexes of interhemispheric signal propagation (ISP) and balance (IHB) by combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG). Methods: We used TMS-EEG to non-invasively stimulate the two hemispheres of 50 healthy volunteers and measured interhemispheric dynamics in terms of ISP and IHB. We repeated our evaluation after three weeks to assess the reliability of our indexes. We also tested whether our TMS-EEG measures were correlated with traditional interhemispheric inhibition (IHI), as measured with motor-evoked potentials (MEPs). Results: Our main results showed that ISP and IHB (1) have a high reproducibility among all the participants tested; (2) have a high test-retest reliability (3) are linearly correlated with IHI, as measured with MEPs. Conclusions: The main contribution of this study lies in the proposal of new TMS-EEG cortical measures of interhemispheric dynamics and in their validation in terms of intra-and inter-subject reliability. We also provide the first demonstration of the correlation between ISP and IHI. Significance: Our results are relevant for the investigation of interhemispheric dynamics in clinical populations where MEPs are not reliable.

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“…We noted with interest that the Q‐Motor speeded tapping measures recorded in the “digitomotography” assessment provided a sensitive measure for correlations with cortical oscillations in the theta frequency band. Casula and colleagues conclude: “participants who showed better timed motor performance also showed stronger oscillatory synchronization”—see their figure 4 showing the “Inter‐Tap‐Interval‐Standard‐Deviation.” This is consistent with correlations seen between speeded tapping intervals and their variability and caudate volumes, white matter volumes, cortical thickness, diffusion tensor imaging, magnetization transfer imaging, and magnetic resonance spectroscopy in HD . Tapping is thought to represent fine motor control and coordination with a strong link to voluntary motor function …”

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confidence: 83%

“…We read with interest the article by Casula and colleagues titled “Motor Cortex Synchronization Influences the Rhythm of Motor Performance in Premanifest Huntington's Disease.” We are pleased to see that the sensitivity provided by rater‐independent objective and quantitative‐motor (Q‐Motor) measures helps to shed light on the functional relevance of transcranial magnetic stimulation (TMS) in Huntington's disease (HD).…”

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confidence: 99%