Motor Cortex Function in Fibromyalgia: A Study by Functional Near-Infrared Spectroscopy

Gentile, Eleonora; Ricci, Katia; Delussi, Marianna; Brighina, Filippo; Tommaso, Marina de

doi:10.1155/2019/2623161

Cited by 19 publications

(36 citation statements)

References 36 publications

(43 reference statements)

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“…The main results of the present study partly confirmed previous findings [21]. Patients suffering from FM had a reduced motor performance as tested by finger tapping task, and a reduced tone of cortical motor areas, especially evident during fast movement.…”

Section: Discussionsupporting

confidence: 92%

“…We did not observe a compensatory activity of right hemisphere in FM patients, as generally occurs in unilateral motor cortex dysfunction [47] The hypometabolism here observed in FM patients could involve the bilateral cortical motor areas, with an absence of contralateral compensation during simple unilateral motor activities. We can assume that the activation levels of the motor cortex were independent of the velocity of the finger tapping task, as, in line with our previous study [21], we did not find any relevant correlation between the motor speed and haemodynamic responses either in patients or in controls. The results of haemodynamic responses suggest that FM patients could have a dysfunction in supplementary and primary motor cortex modulation.…”

Section: Reduced Motor Performance and Motor Cortical Areas Activatiosupporting

confidence: 91%

“…The LEPs amplitude decreased during the movement task both in patients and controls, though the FM group showed greater internal variability. In the present study, we aimed to enlarge the experimental sample and data analysis to confirm preliminary results [21].…”

Section: Introductionmentioning

confidence: 83%

“…The co-recording of EEG and functional Near-Infrared Spectroscopy (fNIRS) has been demonstrated to be a very promising technique to explore both electrical and metabolic activities [17] during multimodal stimulations condition. In our preliminary study [18] we adopted a concomitant recording fNIRS and laser evoked potentials (LEPS) to explore the complex mutual interference between motor cortex activation and the processing of painful stimuli in FM patients and healthy subjects. The choice of the multimodal method of EEG-fNIRS simultaneous recording was aimed at exploring the electrophysiological and functional mechanisms underlying the voluntary activation of cortical areas involved in movement and pain processing one.…”

Section: Introductionmentioning

confidence: 99%

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Mutual interaction between motor cortex activation and pain in fibromyalgia: EEG-fNIRS study

et al. 2020

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Background Experimental and clinical studies suggested an analgesic effect on chronic pain by motor cortex activation. The present study explored the complex mechanisms of interaction between motor and pain during performing the slow and fast finger tapping task alone and in concomitant with nociceptive laser stimulation. Method The participants were 38 patients with fibromyalgia (FM) and 21 healthy subjects. We used a simultaneous multimodal method of laser-evoked potentials and functional near-infrared spectroscopy to investigate metabolic and electrical changes during the finger tapping task and concomitant noxious laser stimulation. Functional near-infrared spectroscopy is a portable and optical method to detect cortical metabolic changes. Laser-evoked potentials are a suitable tool to study the nociceptive pathways function. Results We found a reduced tone of cortical motor areas in patients with FM compared to controls, especially during the fast finger tapping task. FM patients presented a slow motor performance in all the experimental conditions, requesting rapid movements. The amplitude of laser evoked potentials was different between patients and controls, in each experimental condition, as patients showed smaller evoked responses compared to controls. Concurrent phasic pain stimulation had a low effect on motor cortex metabolism in both groups nor motor activity changed laser evoked responses in a relevant way. There were no correlations between Functional Near-Infrared Spectroscopy (FNIRS) and clinical features in FM patients.

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Section: Discussionsupporting

confidence: 92%

Section: Reduced Motor Performance and Motor Cortical Areas Activatiosupporting

confidence: 91%

Section: Introductionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

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Mutual interaction between motor cortex activation and pain in fibromyalgia: EEG-fNIRS study

et al. 2020

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“…The inter-stimulus interval was fixed at 10 s. For each participant, we evaluated the subjective pain threshold according to the method of the limits, and we delivered laser stimuli when the subjects felt a pinprick sensation [17]. The experimenter asked each participant to rate his/her pain on a numerical rating scale (NRS) [18]. After each laser stimulation, the subjects were required to rate the perceived intensity of their pain on the visual analogue scale (VAS) [19].…”

Section: Eeg Recordingmentioning

confidence: 99%

A Simple Pattern of Movement Is Not Able to Inhibit Experimental Pain in FM Patients and Controls: An sLORETA Study

et al. 2020

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Motor cortex activation seems to induce an analgesic effect on pain that would be different between patients with fibromyalgia (FM) and control subjects. This study was conducted to analyze the changes of the laser-evoked potentials (LEPs) induced during a finger tapping task in the FM patients and the controls employing a multi-dipolar analysis according to Standardized low resolution brain electromagnetic tomography (sLORETA) method. The LEPs from 38 FM patients and 21 controls were analyzed. The LEPs were recorded while subjects performed a slow and a fast finger tapping task. We confirmed that the difference between N1, N2 and P2 wave amplitudes between conditions and groups was not significant. In control subjects, the fast finger tapping task induced a modification of cortical source activation in the main areas processing laser stimulation from the moving hand independently from the movement speed. In summary, a simple and repetitive movement is not able to induce consistent inhibition of experimental pain evoked by the moving and the not moving hand in each group. It could interfere with LEP sources within the limbic area at least in control subjects, without inhibit cortical responses or explain the different pattern of motor and pain interaction in FM patients.

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Peripheral and central nervous system correlates in fibromyalgia

Vecchio

Lombardi

Paolini

et al. 2020

European Journal of Pain

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Background: Fibromyalgia (FM) is a syndrome characterized by altered pain processing at central and peripheral level, whose pathophysiologic mechanisms remain obscure. We aimed at exploring the structural changes of peripheral nociceptor measured by skin biopsy, the functional changes of central nociceptive pathway assessed by laser evoked potentials (LEP), and their correlation with clinical features and comorbidities.Methods: Eight-one patients diagnosed with FM underwent skin biopsies with quantification of intraepidermal nerve fiber density (IENFD) at the thigh and distal leg, and LEP recording by stimulating hand, thigh and foot. Nerve conduction study (NCS), clinical features, comorbidity with migraine and mood disorders, and previous, non-active immune-mediated disorders were recorded.Results: IENFD was reduced in 85% of patients at the thigh and in 12.3% of patients at the distal leg, whereas it was normal in 14.8% of patients. N2P2 habituation index from laser stimulation at the thigh was altered in 97.5% of patients and correlated with reduced IENFD at the thigh. LEP latencies and amplitudes did not differ among groups. No association was found between IENFD, LEP, clinical features, and comorbidities.Conclusions: FM patients most commonly showed a mild loss of peripheral nociceptors at the thigh rather than distal small fiber neuropathy. This finding was associated with an altered habituation index and strengthened the hypothesis that central sensitization plays a key role in the pathogenesis of the disease.Significance: Central impairment of pain processing likely underlies FM, which in most patients is associated with mild proximal small fiber pathology.

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Motor Cortex Function in Fibromyalgia: A Study by Functional Near-Infrared Spectroscopy

Cited by 19 publications

References 36 publications

Mutual interaction between motor cortex activation and pain in fibromyalgia: EEG-fNIRS study

Mutual interaction between motor cortex activation and pain in fibromyalgia: EEG-fNIRS study

A Simple Pattern of Movement Is Not Able to Inhibit Experimental Pain in FM Patients and Controls: An sLORETA Study

Peripheral and central nervous system correlates in fibromyalgia

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