2010
DOI: 10.1590/s0004-282x2010000600018
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Motor cortex electric stimulation for the treatment of neuropathic pain

Abstract: Objective: Motor cortex stimulation (MCS) is considered to be an effective treatment for chronic neuropathic pain. The aim of the present study was to assess the efficacy of MCS for treating neuropathic pain. Method: 27 patients with chronic neuropathic pain were operated. Electrodes were implanted with the use of an stereotactic frame. Electrophysiological evaluations (motor stimulation and somatosensory evoked potentials) were performed, with guidance by means of three-dimensional reconstruction of magnetic … Show more

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Cited by 42 publications
(44 citation statements)
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“…Additionally, it is possible that thalamic activation during exercise could hinder the relay of nociceptive signals. This hypothesis is supported by both the robust and direct anatomic connections between the motor cortex and the thalamus, by clinical data showing effective neuropathic pain relief by motor cortex stimulation [84], and by preclinical data where chronic exercise was paralleled by an increased activation of the cerebellar-thalamic-cortical circuit in rats [85], thus providing additional incentive for ongoing physical activity in pain patients. For those patients with reduced mobility, ascending noxious signals can be modulated via guided imagery.…”
Section: Potential Mechanisms Of Actionmentioning
confidence: 96%
“…Additionally, it is possible that thalamic activation during exercise could hinder the relay of nociceptive signals. This hypothesis is supported by both the robust and direct anatomic connections between the motor cortex and the thalamus, by clinical data showing effective neuropathic pain relief by motor cortex stimulation [84], and by preclinical data where chronic exercise was paralleled by an increased activation of the cerebellar-thalamic-cortical circuit in rats [85], thus providing additional incentive for ongoing physical activity in pain patients. For those patients with reduced mobility, ascending noxious signals can be modulated via guided imagery.…”
Section: Potential Mechanisms Of Actionmentioning
confidence: 96%
“…Some centers perform a direct implantation of the neuro-stimulator in the subcutaneous tissue (infraclavicular or abdominal), while others perform also a postoperative testing with externalized extensions of the lead and an external stimulation 98,106,108,109. Such a testing phase allows for a placebo double-blinded stimulation period, so that false positive responders can be identified 106.…”
Section: Invasive Treatment Strategiesmentioning
confidence: 99%
“…The effects of electric currents upon neuronal function have been studied for decades (Priori, 2003). More recently, after several reports of beneficial effects of TMS upon symptoms of many neuropsychiatric disorders, such as depression (Pascual-Leone et al, 1996;Boechat-Barros, 2004;Boechat-Barros & Brasil-Neto, 2004;Leo & Latif, 2007;O'Reardon et al, 2007;Brunoni et al, 2010b;Holtzheimer & Mayberg, 2012;Rothwell, 2012;Iannone et al, 2016) and chronic pain (Nguyen et al, 1999;Leo & Latif, 2007;Rosen et al, 2009;Galhardoni et al, 2015) and neuropathic pain (Brown & Barbaro, 2003;Fagundes-Pereyra et al, 2010;Nguyen et al, 2011;Nizard et al, 2012), transcranial direct current stimulation (tDCS) has also been the subject of many studies due to its ability to modulate cortical function in a non-invasive manner. For that reason, there is a great deal of interest in its potential applications in the fields of neurology and psychiatry (Alonzo et al, 2012;Demirtas-Tatlidede, VahabzadehHagh & Pascual-Leone, 2013;Elder & Taylor, 2014;Flöel, 2014;Kuo, Paulus & Nitsche, 2014;Dedoncker et al, 2016;Iannone et al, 2016).…”
Section: Introductionmentioning
confidence: 99%