Motor control and cognition deficits associated with protein carbamoylation in food (cassava) cyanogenic poisoning: Neurodegeneration and genomic perspectives

Rwatambuga, Furaha A.; Ali, E.R.; Vilain, Éric; Gosschalk, Jason E.; Kim, Morris; Yandju, D. L.; Okitundu, L.; Boivin, Michael J.; Banea, Jean Pierre; Westaway, Shawn K.; Larry, D.; Vilain, Éric; Ngoyi, Dieudonné Mumba; Tshala-Katumbay, Desiré

doi:10.1016/j.fct.2020.111917

Cited by 5 publications

(2 citation statements)

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“… 1283 Spontaneous carbamylation can alter the molecular weight, isoelectric point, and other physical properties of the protein and can also lead to an irreversible decrease in protein activity. 1284 In theory, all proteins in the human body are prone to carbamylation. However, the probability of carbamylation of each protein depends on the number and activity of amino groups and the lifetime of the protein.…”

Section: Carbamylationmentioning

confidence: 99%

“…Cyanate reacts with the amino groups of proteins to form carbamylation 1283 . Spontaneous carbamylation can alter the molecular weight, isoelectric point, and other physical properties of the protein and can also lead to an irreversible decrease in protein activity 1284 . In theory, all proteins in the human body are prone to carbamylation.…”

Section: Carbamylationmentioning

confidence: 99%

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Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Zhong

Xiao

Xie

et al. 2023

MedComm

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Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent bonds on the backbones or amino acid side chains of proteins and expand the diversity of proteins, which provides the basis for the emergence of organismal complexity. To date, more than 650 types of protein modifications, such as the most well‐known phosphorylation, ubiquitination, glycosylation, methylation, SUMOylation, short‐chain and long‐chain acylation modifications, redox modifications, and irreversible modifications, have been described, and the inventory is still increasing. By changing the protein conformation, localization, activity, stability, charges, and interactions with other biomolecules, PTMs ultimately alter the phenotypes and biological processes of cells. The homeostasis of protein modifications is important to human health. Abnormal PTMs may cause changes in protein properties and loss of protein functions, which are closely related to the occurrence and development of various diseases. In this review, we systematically introduce the characteristics, regulatory mechanisms, and functions of various PTMs in health and diseases. In addition, the therapeutic prospects in various diseases by targeting PTMs and associated regulatory enzymes are also summarized. This work will deepen the understanding of protein modifications in health and diseases and promote the discovery of diagnostic and prognostic markers and drug targets for diseases.

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Section: Carbamylationmentioning

confidence: 99%

Section: Carbamylationmentioning

confidence: 99%