Motion energy analysis reveals altered body movement in youth at risk for psychosis

Abstract

This study represents an innovative perspective on gross motor function in the UHR group. Importantly, the automated approach used in this study provides a sensitive and objective measure of body movement abnormalities, potentially guiding novel assessment and prevention of symptom development in those at risk for psychosis.

Objective and quantitative equilibriometric evaluation of individual locomotor behaviour in schizophrenia: Translational and clinical implications

“…Schizophrenia is conceived as a form of the same cerebellar cognitive affective syndrome, ie, as involving cerebellar dysfunctions. Our data are corresponding well to those concepts and suggest that the equilibriometric dysmetric and ataxic LMPs in schizophrenia are in fact subclinical equivalents of the cerebellar neurological signs and more specifically of the balance and motor coordination deficits, which are often revealed in schizophrenic patients and preschizophrenic high‐risk populations . Although indirectly, these subtle locomotor irregularities provide further evidence that schizophrenia is a brain disease, affecting functional neural circuits, which engage the prefrontal cortex, thalamus, basal ganglia, and cerebellum, as well as particular neurotransmitters, such as dopamine and glutamate .…”

“…With relatively few exceptions (limited to the most disorganized and severely psychotic or negativistic cases), the majority of patients follow the instructions and cooperate adequately during the test. Nowadays, it is already confirmed that the objectively evaluated neuromotor and psychomotor disturbances reflect the brain dysfunctions in schizophrenia more reliably than the subjective symptoms . Our research data provide further evidence that the treatment decisions for the individual schizophrenic patients are more correct if they are guided by the objectively measured LMPs .…”

“…Nowadays, it is already confirmed that the objectively evaluated neuromotor and psychomotor disturbances reflect the brain dysfunctions in schizophrenia more reliably than the subjective symptoms. 31,36,46,49,50,[58][59][60] Our research data provide further evidence that the treatment decisions for the individual schizophrenic patients are more correct if they are guided by the objectively measured LMPs. 4,5 Such an objective and quantitative evaluation at a single-patient level is in line with the modern tendency for personalized 36,61,62 and precision 63,64 medicine in the psychiatric neuroscience research, aimed at replacing the traditional categorical diagnostic approach with a more dimensional one 64-68 that looks for "theranostic" 69 rather than for diagnostic biomarkers.…”

“…Despite their objective character, however, in the everyday clinical practice, these motor disturbances are still recorded and evaluated subjectively, by clinical observation and description. Just in the recent years, a few motion analysis laboratories began to evaluate them by objective instrumental methods . Hence, it is reasonable to presume that (in the absence of clinically manifested neurological symptoms) the abnormal LMPs in the majority of schizophrenic patients reflect psychomotor disturbances .…”

Quantification of nonverbal synchrony using linear time series analysis methods: Lack of convergent validity and evidence for facets of synchrony

“…; in ecological psychology (Davis, Kay, Kondepudi, & Dixon, 2016); for the diagnosis of psychological disorders (Dean, Samson, Newberry, & Mittal, 2018;Dutschke et al, 2018;Kupper, Ramseyer, Hoffmann, Kalbermatten, & Tschacher, 2010;Kupper, Ramseyer, Hoffmann, & Tschacher, 2015); and in psychotherapy (Galbusera, Finn, & Fuchs, 2018;Paulick et al, 2018;Ramseyer, 2011Ramseyer, , 2013Ramseyer & Tschacher, 2011, 2016.…”