motility

O’Toole, Paul W.; Lane, Michael; Porwollik, Steffen

doi:10.1016/s1286-4579(00)01274-0

Cited by 79 publications

(79 citation statements)

References 52 publications

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“…This group of iron-repressed genes includes five motility-associated genes, the fliD, fliI, fliM, fliY and flgI genes, encoding components of the flagellum of H. pylori (O'Toole et al, 2000). Their regulation by iron may explain the effect of iron restriction and acid exposure on the motility of H. pylori (Merrell et al, 2003b).…”

Section: Iron-responsive Regulation Independent Of Furmentioning

confidence: 99%

Transcriptional profiling of Helicobacter pylori Fur- and iron-regulated gene expression

et al. 2005

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Intracellular iron homeostasis is a necessity for almost all living organisms, since both iron restriction and iron overload can result in cell death. The ferric uptake regulator protein, Fur, controls iron homeostasis in most Gram-negative bacteria. In the human gastric pathogen Helicobacter pylori, Fur is thought to have acquired extra functions to compensate for the relative paucity of regulatory genes. To identify H. pylori genes regulated by iron and Fur, we used DNA array-based transcriptional profiling with RNA isolated from H. pylori 26695 wild-type and fur mutant cells grown in iron-restricted and iron-replete conditions. Sixteen genes encoding proteins involved in metal metabolism, nitrogen metabolism, motility, cell wall synthesis and cofactor synthesis displayed iron-dependent Fur-repressed expression. Conversely, 16 genes encoding proteins involved in iron storage, respiration, energy metabolism, chemotaxis, and oxygen scavenging displayed iron-induced Fur-dependent expression. Several Fur-regulated genes have been previously shown to be essential for acid resistance or gastric colonization in animal models, such as those encoding the hydrogenase and superoxide dismutase enzymes. Overall, there was a partial overlap between the sets of genes regulated by Fur and those previously identified as growth-phase, iron or acid regulated. Regulatory patterns were confirmed for five selected genes using Northern hybridization. In conclusion, H. pylori Fur is a versatile regulator involved in many pathways essential for gastric colonization. These findings further delineate the central role of Fur in regulating the unique capacity of H. pylori to colonize the human stomach.

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Section: Iron-responsive Regulation Independent Of Furmentioning

confidence: 99%

Transcriptional profiling of Helicobacter pylori Fur- and iron-regulated gene expression

et al. 2005

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“…teriaceae indicated that regulation and biosynthesis of flagella in C. jejuni is likely to be different from that of the Enterobacteriaceae (Chilcott & Hughes, 2000 ;Macnab, 1996 ;Parkhill et al, 2000), more closely resembling the organization predicted for the related pathogen Helicobacter pylori (O'Toole et al, 2000 ;Tomb et al, 1997). C. jejuni contains the flagellar sigma factors σ#) and σ&% (Jagannathan et al, 2001 ;Wo$ sten et al, 1998a) and a homologue of the H. pylori flgR gene, which encodes a σ&%-associated activator of transcription of the flagellar hook, basal body and FlaB flagellar filament genes (Jagannathan et al, 2001 ;Spohn & Scarlato, 1999).…”

Section: Introductionmentioning

confidence: 97%

Mutational and transcriptional analysis of the Campylobacter jejuni flagellar biosynthesis gene flhB

et al. 2002

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“…pylori is a gram negative microaerophilic bacteria whose optimum growth is at an oxygen level of 2-5 % with a high humidity level [1,2]. It was discovered by Marshall and Warren in 1983 and is one of the most successful human pathogens [3].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of H. Pylori in Tonsillar Tissue of Patients with Chronic Recurrent Tonsillitis Using Rapid Urease Test in a Tertiary Referral Hospital in Sub Saharan Africa

Ochung’o

Mugwe

Masinde

et al. 2014

Indian J Otolaryngol Head Neck Surg

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There has been conflicting results regarding the presence of H. pylori in tonsillar tissue. Our objective was to analyze for the presence of H. pylori in tonsillar tissue in patients undergoing tonsillectomy for chronic recurrent tonsillitis using rapid urease test in a Tertiary care academic medical center in a sub Saharan hospital. A prospective cross-sectional analysis of 39 consecutive cases of patients undergoing tonsillectomy secondary to chronic recurrent tonsilitis was done. Rapid urease test was conducted on each tonsillectomy tissue and results were determined using color change at specific time intervals within 24 h. Average age of the patients was 4.3 years. Among the 39 tonsillar tissues analysed using rapid urease test, H. pylori was present in 30.5 % of the samples. Colonisation by H. pylori of the palatine tonsils is a new frontier with conflicting results depending on the accuracy of the test method used and population studied. More studies need to be performed to ascertain the different rates of colonisation based on geographical regions.

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motility

Cited by 79 publications

References 52 publications

Transcriptional profiling of Helicobacter pylori Fur- and iron-regulated gene expression

Transcriptional profiling of Helicobacter pylori Fur- and iron-regulated gene expression

Mutational and transcriptional analysis of the Campylobacter jejuni flagellar biosynthesis gene flhB

Prevalence of H. Pylori in Tonsillar Tissue of Patients with Chronic Recurrent Tonsillitis Using Rapid Urease Test in a Tertiary Referral Hospital in Sub Saharan Africa

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