Mosquito salivary gland antigens identified by circulating human antibodies

Penneys, N. S.

doi:10.1001/archderm.125.2.219

Cited by 14 publications

(11 citation statements)

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“…immunohistochemistry [10]. or immunoblot techniques [ 11,17]. but to our knowledge there are no previous studies measuring these antibodies before and after exposure to mosquitoes.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous reactivity to mosquito bites: effect of cetirizine and development of anti‐mosquito antibodies

Reunala¹,

Lappalainen

Brummer‐Korvenkontio

et al. 1991

Clin Experimental Allergy

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Cutaneous reactivity to mosquito bites was examined in 27 adult volunteers exposed to Aedes communis mosquitoes. Twenty-three subjects showed a combination of immediate wealing and delayed bite-papules, two subjects each experienced only immediate or delayed cutaneous reactions and two were non-responsive to the bites. The mean size of wealing and the mean score of pruritus was similar in 19 non-atopic and in eight atopic volunteers. These results confirm that normal subjects exhibit different stages of sensitization to mosquito bites. At the onset of the mosquito season, immunoblotting showed that four of 21 subjects (19%) had IgG-class antibodies to a recently described 21.5 kD Aedes communis mosquito antigen. After a 10-day exposure to a mean of 47 mosquito bites, these antibodies were found in 10 subjects (48%) who exhibited both strong and weak cutaneous bite-lesions. A placebo-controlled, double-blind study with cetirizine 10 mg was performed to examine the effect of this non-sedating antihistamine on mosquito bites. The bite lesions were measured and pruritus scored at 15 min, 60 min, 12 hr, and 24 hr. Cetirizine decreased significantly immediate wealing and pruritus (P less than 0.01), but had no effect on the delayed symptoms. This result supports the view that immediate mosquito-bite reactions are histamine-mediated.

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“…immunohistochemistry [10]. or immunoblot techniques [ 11,17]. but to our knowledge there are no previous studies measuring these antibodies before and after exposure to mosquitoes.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous reactivity to mosquito bites: effect of cetirizine and development of anti‐mosquito antibodies

Reunala¹,

Lappalainen

Brummer‐Korvenkontio

et al. 1991

Clin Experimental Allergy

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“…Most of the proteins in mosquito saliva are allergenic in humans [23, 46, 47, 53, 54, 55]. Using immunoblot analyses with a pooled serum from individuals allergic to mosquito bites, allergens in the saliva or salivary gland extracts from 10 world-wide distributed mosquito species were studied [47](fig.…”

Section: Mosquito Salivary Allergens and Commercial Extractsmentioning

confidence: 99%

Mosquito Allergy: Immune Mechanisms and Recombinant Salivary Allergens

Peng

Simons²

2004

Int Arch Allergy Immunol

124

105

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Reactions to mosquito bites are immunological in nature, with the involvement of IgE-, IgG- and T lymphocyte-mediated hypersensitivities. Acquired desensitization to mosquito saliva may occur during childhood and adolescence or during long-term exposure to mosquito bites. Due to the lack of salivary preparations, allergic reactions to mosquito bites are underdiagnosed and undertreated. Recombinant mosquito saliva allergens with biological activity are being developed. These recombinant allergens will significantly improve diagnosis of mosquito allergy and eventually will also improve specific immunotherapy for patients with systemic reactions to mosquito bites.

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“…Penneys et at. [21] used salivary gland extracts from five different mosquito species and serum samples from human subjects as a source of AMAB. They could identify several antigenic components ranging from 14 to 126 kD but only a 62 kD compound was common to all five mosquito species examined.…”

Section: Antigensmentioning

confidence: 99%

Immunology and treatment of mosquito bites

Reunala

Brummer‐Korvenkontio

Lappalainen

et al. 1990

Clin Experimental Allergy

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Cutaneous reactions to mosquito bites are usually pruritic weals and delayed papules. Arthus-type local and systemic symptoms can also occur but anaphylactic reactions are very rare. Both clinical and experimental evidence suggest that the various bite reactions result from sensitization to the mosquito saliva injected into the skin during feeding. Recent immunoblot studies have shown both IgG- and IgE-class anti-mosquito antibodies, but their species-specificity and clinical importance is at present unknown. In addition to an Arthus-type mechanism, both cutaneous late-phase reactivity and cell-mediated immunity may be involved in the pathophysiology of delayed mosquito-bite lesions. Cutaneous sensitization to mosquito bites can be divided into five different stages ranging from the stages of immediate wealing and delayed bite papules, to the stage of non-reactivity. No desensitization treatment is generally available for mosquito allergy but it has recently been shown that cetirizine, a potent non-sedating antihistamine, is effective against the wealing and pruritus caused by mosquito bites.

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Mosquito salivary gland antigens identified by circulating human antibodies

Cited by 14 publications

References 0 publications

Cutaneous reactivity to mosquito bites: effect of cetirizine and development of anti‐mosquito antibodies

Cutaneous reactivity to mosquito bites: effect of cetirizine and development of anti‐mosquito antibodies

Mosquito Allergy: Immune Mechanisms and Recombinant Salivary Allergens

Immunology and treatment of mosquito bites

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