Mosquito Infestation and Dengue Virus Infection in Aedes aegypti Females in Schools in Mérida, México

García-Rejón, Julián E.; Loroño-Pino, María Alba; Farfán-Ale, José A.; Flores-Flores, Luis F.; López-Uribe, Mildred P.; Nájera-Vázquez, Maria del Rosario; Nuñez-Ayala, Guadalupe; Beaty, Barry J.; Eisen, Lars

doi:10.4269/ajtmh.2011.10-0654

Cited by 62 publications

(62 citation statements)

References 47 publications

(52 reference statements)

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“…We also focused on individuals who reported visiting at least one other household because we could only assess exposure in houses with participants who agreed to provide blood samples. Exposure could occur wherever infectious mosquitoes are present (44)(45)(46). In Iquitos, people commonly visit other residences, but in other geographic areas, people may be more or less mobile, making the home or other locations comparatively more important for transmission.…”

Section: Discussionmentioning

confidence: 99%

House-to-house human movement drives dengue virus transmission

Stoddard

Forshey

Morrison

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

447

425

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Dengue is a mosquito-borne disease of growing global health importance. Prevention efforts focus on mosquito control, with limited success. New insights into the spatiotemporal drivers of dengue dynamics are needed to design improved disease-prevention strategies. Given the restricted range of movement of the primary mosquito vector, Aedes aegypti, local human movements may be an important driver of dengue virus (DENV) amplification and spread. Using contact-site cluster investigations in a case-control design, we demonstrate that, at an individual level, risk for human infection is defined by visits to places where contact with infected mosquitoes is likely, independent of distance from the home. Our data indicate that house-to-house human movements underlie spatial patterns of DENV incidence, causing marked heterogeneity in transmission rates. At a collective level, transmission appears to be shaped by social connections because routine movements among the same places, such as the homes of family and friends, are often similar for the infected individual and their contacts. Thus, routine, house-to-house human movements do play a key role in spread of this vector-borne pathogen at fine spatial scales. This finding has important implications for dengue prevention, challenging the appropriateness of current approaches to vector control. We argue that reexamination of existing paradigms regarding the spatiotemporal dynamics of DENV and other vectorborne pathogens, especially the importance of human movement, will lead to improvements in disease prevention.infectious disease | spatial epidemiology | arthropod-borne virus | emerging infections | disease ecology D engue is a mosquito-borne viral infection prevalent in the tropics and subtropics with an incidence and range that have increased substantially over the last three decades (1-4). The incidence of severe, life-threatening disease (dengue hemorrhagic fever or DHF) is also on the rise (5). Dengue virus (DENV) is caused by any of four closely related, but antigenically distinct and genetically diverse, virus serotypes (DENV-1, -2, -3, and -4), which are transmitted by day-biting, peridomestic Aedes mosquitoes, primarily Aedes aegypti (6). Incompletely understood immunological interactions among serotypes that can enhance disease severity (7-9) have hampered the development of effective, commercially available vaccines. A recent trial of a promising vaccine candidate demonstrated only partial (<33%) protection (10). Effective antiviral therapeutics are also not available. Thus, despite nearly a century of research, the only tools presently available to combat dengue target mosquito populations, mostly with insecticides and larval source reduction. In current practice, these tools are most often only partially effective (11). Although new vector control approaches are under development (12), innovations in dengue-control approaches are constrained by our limited understanding of virus-transmission dynamics and its drivers. In particular, the role of human movemen...

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Section: Discussionmentioning

confidence: 99%

House-to-house human movement drives dengue virus transmission

Stoddard

Forshey

Morrison

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

447

425

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“…aegypti is the primary mosquito vector. 9,22,25,26 Study areas were identified for similarity in potential study homes, e.g., cement construction, size, and design, typically found in fraccionamiento neighborhoods, which are comprised of high-density and lowincome housing. Homes with more than one story, more than 10 windows, less than four inhabitants, or no children 15 years of age were excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

“…[11][12][13][14][15][16][17][18][19][20][21] Because of the endophilic nature of Ae. aegypti, tools or approaches to exclude it from the epidemiologically most significant points of contact with humans, the home and other frequently used indoor environments, such as schools or workplaces, 9,22 would be an important addition to the armamentarium for dengue control. This type of intervention theoretically not only prevents DENV-infected female mosquitoes from entering homes and other indoor environments, such as schools or workplaces, but also prevents mosquitoes from feeding indoors on viremic humans, including while they are recuperating in the home, and then transmitting the virus to other humans frequenting the domicile.…”

Section: Introductionmentioning

confidence: 99%

Towards a Casa Segura: A Consumer Product Study of the Effect of Insecticide-Treated Curtains on Aedes aegypti and Dengue Virus Infections in the Home

Loroño-Pino¹,

García-Rejón²,

Machaín-Williams³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. The home, or domicile, is the principal environment for transmission of dengue virus (DENV) between humans and mosquito vectors. Community-wide distribution of insecticide-treated curtains (ITCs), mimicking vector control program-driven interventions, has shown promise to reduce DENV infections. We conducted a Casa Segura consumer product intervention study in Mérida, Mexico to determine the potential to reduce intradomicillary DENV transmission through ITC use in individual homes. Dengue virus infections in mosquitoes and in humans were reduced in homes with ITCs in one of two study subareas. Overall, ITCs reduced intradomicillary DENV transmission; ITC homes were significantly less likely to experience multiple DENV infections in humans than NTC homes. Dengue virus-infected Aedes aegypti females were reduced within the ITC homes where curtain use was highest. Some homes yielded up to nine infected Ae. aegypti females. This study provides insights regarding best practices for Casa Segura interventions to protect homes from intradomicillary DENV transmission.

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“…However, it has been shown that 16.1% of the Ae. aegypti females that were collected from Mexican schools were infected with DENV (García-Rejón et al 2011). In Brazil, previous studies showed that 17% of the Ae.…”

Section: Simplexa™ Dengue Real-time Rt-pcr -mentioning

confidence: 99%

Dengue virus type 4 in Niterói, Rio de Janeiro: the role of molecular techniques in laboratory diagnosis and entomological surveillance

Castro¹,

Nogueira²,

Filippis³

et al. 2012

Mem. Inst. Oswaldo Cruz

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In Niterói, state of Rio de Janeiro, dengue virus type 4 (DENV-4) was isolated for the first time in March 2011. We analysed the laboratory findings of the first cases and evaluated the use of molecular techniques for the detection of DENV-4 in Aedes aegypti that were field-caught. Conventional reverse transcriptase-polymerase chain reaction (RT-PCR) and SimplexaTM Dengue real-time RT-PCR confirmed DENV-4 infection in all cases. Additionally, DENV-4 was confirmed in a female Ae. aegypti with 1.08 x 10³ copies/mL of virus, as determined by quantitative real-time RT-PCR. This is the first time the SimplexaTM Dengue real-time assay has been used for the classification of cases of infection and for entomological investigations. The use of these molecular techniques was shown to be important for the surveillance of dengue in humans and vectors

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Mosquito Infestation and Dengue Virus Infection in Aedes aegypti Females in Schools in Mérida, México

Cited by 62 publications

References 47 publications

House-to-house human movement drives dengue virus transmission

House-to-house human movement drives dengue virus transmission

Towards a Casa Segura: A Consumer Product Study of the Effect of Insecticide-Treated Curtains on Aedes aegypti and Dengue Virus Infections in the Home

Dengue virus type 4 in Niterói, Rio de Janeiro: the role of molecular techniques in laboratory diagnosis and entomological surveillance

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