Mosaic genealogy of the Mus musculus genome revealed by 21 nuclear genes from its three subspecies

Liu, Yuhua; Takahashi, Aya; Kitano, Takashi; Koide, Tsuyoshi; Shiroishi, Toshihiko; Moriwaki, Kazuo; Saitou, Naruya

doi:10.1266/ggs.83.77

Cited by 20 publications

(18 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result agrees with the phylogenetic history of house mice. High levels of phylogenetic discordance among gene trees indicate that the ancestor of M. m. musculus and M. m. castaneus diverged rapidly from the M. m. domesticus lineage (Tucker et al 1989;Prager et al 1996Prager et al , 1998Lundrigan et al 2002;Goios et al 2007;Geraldes et al 2008;Liu et al 2008;White et al 2009;Keane et al 2011). The short internal branch leading from the root to the most recent common ancestor of M. m. musculus and M. m. castaneus provided little time for derived-derived incompatibilities (Orr 1995) to evolve.…”

Section: Discussionmentioning

confidence: 99%

Genetics and Evolution of Hybrid Male Sterility in House Mice

White¹,

Stubbings

Dumont³

et al. 2012

Genetics

105

View full text Add to dashboard Cite

Comparative genetic mapping provides insights into the evolution of the reproductive barriers that separate closely related species. This approach has been used to document the accumulation of reproductive incompatibilities over time, but has only been applied to a few taxa. House mice offer a powerful system to reconstruct the evolution of reproductive isolation between multiple subspecies pairs. However, studies of the primary reproductive barrier in house mice-hybrid male sterility-have been restricted to a single subspecies pair: Mus musculus musculus and Mus musculus domesticus. To provide a more complete characterization of reproductive isolation in house mice, we conducted an F 2 intercross between wild-derived inbred strains from Mus musculus castaneus and M. m. domesticus. We identified autosomal and X-linked QTL associated with a range of hybrid male sterility phenotypes, including testis weight, sperm density, and sperm morphology. The pseudoautosomal region (PAR) was strongly associated with hybrid sterility phenotypes when heterozygous. We compared QTL found in this cross with QTL identified in a previous F 2 intercross between M. m. musculus and M. m. domesticus and found three shared autosomal QTL. Most QTL were not shared, demonstrating that the genetic basis of hybrid male sterility largely differs between these closely related subspecies pairs. These results lay the groundwork for identifying genes responsible for the early stages of speciation in house mice.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetics and Evolution of Hybrid Male Sterility in House Mice

White¹,

Stubbings

Dumont³

et al. 2012

Genetics

105

View full text Add to dashboard Cite

show abstract

“…In the analyses of complex traits in wild-derived strains, we identified a marked diversity of phenotypes among strains [12,17,24,29]. The phenotypic diversity is believed to be a result of genetic diversity among wild-derived strains, as shown by several studies on genomic polymorphisms of these strains [17,18,20,23,27]. As each wild-derived strain has a different evolutionary history, we can expect a unique haplotype in each strain [16].…”

Section: Proposal Of a New Approach To Elucidate Complex Traitsmentioning

confidence: 95%

Genomic Mixing to Elucidate the Genetic System of Complex Traits

2012

Self Cite

View full text Add to dashboard Cite

Abstract:Understanding the genetic basis of complex traits has become one of the major issues in genetics, but recent advances in this field are still faced with a difficulty, the so-called "missing heritability." It is speculated that missing heritability mainly stems from a large number of variants of small effect that are poorly detected by currently available methods. In order to overcome this problem, many recent genetic studies of complex traits have actively used outbred stocks of mice. However, most of the available outbred stocks have a limited amount of genetic variation, because many stocks originate from Swiss mouse colonies. We have repeatedly shown that wild-derived strains are a useful mouse resource since there is a large genetic diversity among these strains. Here, we give an overview of mouse resources produced by crossing different founder mice. Finally, we propose an advantage of new attempts to conduct selective breeding using heterogeneous stocks created by mixing genomes of wild-derived inbred strains of mice when studying complex traits.

show abstract

“…Recent parsimony analysis of SSLP in 54 CIS indicated that C57-derived strains are apparently distantly related to the other CIS group [28]. Liu et al [9] have investigated mouse genome genealogy using 21 nuclear genes in CIS and WIS. Two genes of C57BL/10, Dfy (Duffy-like blood group) on chromosome 1 and Tnf (tumor necrosis factor) on chromosome 17 were MUS type. BAC-end sequence-SNP analysis of the MSM strain demonstrated that around 6% of its genome is similar to that of C57BL/6 [1].…”

Section: Unique Phylogenetic Status Of the C57bl Strain In The Phylogmentioning

confidence: 99%

Unique Inbred Strain MSM/Ms Established from the Japanese Wild Mouse

et al. 2009

Self Cite

View full text Add to dashboard Cite

Most laboratory mice belong to a species of house mouse, Mus musculus. So far, at least three subspecies groups have been recognized; domesticus subspecies group (DOM) distributed in western Europe, musculus subspecies group (MUS) distributed in eastern Europe and northeast Asia, and castaneus subspecies group (CAS) found in southwest and southeast Asia including southern China. These subspecies are estimated to have branched off roughly one million years ago. Genetic comparison between subspecies' groups and common inbred strains (CIS) have revealed that the genetic background of CIS is derived mainly from DOM. This shows the importance of non-DOM wild mice as valuable genetic resources. We started to establish our unique strain, MSM/Ms, from MUS in Japan in 1978. In the beginning, we kept wild mice trapped in Mishima in large plastic buckets. In 1979, breeding by sister-brother mating started. The MSM/Ms inbred strain was established in 1986 and 21 years later it reached F 100 . During breeding, no significant fluctuations in litter size and sex ratios have been observed. Extensive genetic analyses of chromosome C-banding pattern, biochemical markers and microsatellite DNA (MIT) markers of this strain have demonstrated the characteristics of MUS. A phylogenetic tree constructed from MIT markers has confirmed the MUS nature of MSM strain. Taken together with its genetic remoteness from CIS, MSM appears to maintain many valuable alleles for investigation of biological functions and diseases. Some of these alleles have avoided selection during breeding as either fancy mice or laboratory mice. The MSM-specific genetic traits discovered to date are discussed.

show abstract

Mosaic genealogy of the Mus musculus genome revealed by 21 nuclear genes from its three subspecies

Cited by 20 publications

References 53 publications

Genetics and Evolution of Hybrid Male Sterility in House Mice

Genetics and Evolution of Hybrid Male Sterility in House Mice

Genomic Mixing to Elucidate the Genetic System of Complex Traits

Unique Inbred Strain MSM/Ms Established from the Japanese Wild Mouse

Contact Info

Product

Resources

About