MortalityPredictors.org: a manually-curated database of published biomarkers of human all-cause mortality

Peto, Maximus V.; Guardia, Carlos De la; Winslow, Ksenia; Ho, Andrew Fu Wah; Fortney, Kristen; Morgen, Eric K.

doi:10.18632/aging.101280

Cited by 8 publications

(8 citation statements)

References 34 publications

(38 reference statements)

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“…Many clinical measures are associated with all-cause mortality or predict risk of mortality including C-reactive protein (CRP) 16 , red cell distribution width (RDW) 17 , homeostatic model assessment insulin resistance (HOMA-IR) 18 , growth differential factor 15 (GDF15; also known as MIC-1) 19,20 , total white blood cell (WBC) count 21 , serum albumin 22 , serum alkaline phosphatase (ALP), estimated glomerular filtration rate (eGFR), mean cell volume (MCV), triglycerides, cholesterol, elevated blood pressure and elevated body mass index (BMI) 23 . Although progress has been made in identifying and documenting the use of clinical mortality markers, examination of EVs and their cargo in a middle-aged, racially diverse cohort as novel biomarkers of mortality risk could be useful to enhance identification of those at highest risk.…”

Section: Introductionmentioning

confidence: 99%

Association of Extracellular Vesicle Protein Cargo with Race and Clinical Markers of Mortality

Hooten

McFarland

Freeman

et al. 2019

Sci Rep

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Differential mortality rates remain a significant health disparity in the United States, suggesting the need to investigate novel potential molecular markers associated with mortality. Extracellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies, are lipid-bound vesicles secreted by cells into the circulation. EVs mediate intercellular communication by shuttling functional signaling molecules as cargo. EV characteristics by race in the context of mortality risk factors have not been described. We isolated plasma EVs from a cross-sectional cohort of African Americans (AA) and whites and found no significant differences in EV size, distribution or concentration between race or by sex. However, EV cargo showed increased levels of phospho-p53, total p53, cleaved caspase 3, ERK1/2 and phospho-AKT in white individuals compared to AAs. phospho-IGF-1R levels were significantly higher in females compared to males. EV concentration was significantly associated with several clinical mortality risk factors: high-sensitivity C-reactive protein (hsCRP), homeostatic model assessment of insulin resistance (HOMA-IR), alkaline phosphatase, body mass index, waist circumference and pulse pressure. The association of EV proteins with mortality markers were dependent on race. These data suggest that EV cargo can differ by race and sex and is associated with mortality risk factors.

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Section: Introductionmentioning

confidence: 99%

Association of Extracellular Vesicle Protein Cargo with Race and Clinical Markers of Mortality

Hooten

McFarland

Freeman

et al. 2019

Sci Rep

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“…2 Clinical applications of biomarkers generally include prognosticating for individual older patients, identifying high-risk older patients during hospitalisation and helping healthcare workers decide on the best treatment options. 15,16 In this study, we found low systolic blood pressure (SBP < 120 mmHg) and elevated temperature (≥ 39.0°C) to be the independent predictors of all-cause mortality among older medical hospital inpatients.…”

Section: Discussionmentioning

confidence: 58%

Biomarkers, shock index and modified early warning score among older medical hospital inpatients in Nigeria

Adebusoye

Owolabi

Ogunniyi

2019

South African Family Practice

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Background: Biomarkers, shock index and modified early warning score (MEWS) are of public health importance because identification and prompt attention to them have been found to reduce mortality among older patients on admission. Objectives: A study was undertaken to determine the biomarkers, shock index and MEWS that predict mortality on admission among older medical hospital inpatients. Methods: This was a prospective study of 450 patients (≥ 60 years) on the medical wards of University College Hospital, Ibadan. Biomarkers recommended by the National Institute on Aging such as blood pressure, heart rate and pulse rate (cardiovascular functioning); cholesterol and triglycerides (metabolic processes); T-cell counts (immune system status) and weight, body mass index and waist-to-hip ratio (indicators of obesity, chronic metabolic disorders and fat deposits) were assessed. Vital signs were recorded on admission and used to calculate the shock index and MEWS. Multivariate and survival analyses were carried out at p < 0.05. Results: Baseline temperature ≥ 39.0°c (p = 0.049), pulse rate ≥ 100 beats/minute (p = 0.034), systolic blood pressure (SBP) < 120 mmHg (p = 0.048), shock index ≥1.0 (p = 0.041), age shock index (p = 0.032) and critical illness score (MEWS ≥5) p = 0.019 were significantly associated with mortality. Independent predictors of mortality on Cox regression analysis were temperature ≥ 39.0°C (HR = 3.317 [1.281-8.590]) and SBP < 120 mmHg (HR = 1.845 [1.025-3.322]). Conclusion: Prompt identification and management of fever and low blood pressure should improve the survival of older medical hospital inpatients.

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“…The effect size of the relationship with mortality (hazard ratios between 1.1 and 1.4 in our cohorts) is comparable to that of existing, clinically-important biomarkers of mortality such as cholesterol (HR=1.12 per mmol/L increase) and systolic blood pressure (HR=1.13 per 10 mm Hg increase) [32, 33]. Importantly, the predictive utility of glucuronic acid persists after adjustment for standard clinical covariates and other accepted predictors of mortality, including factors such as demographics, BMI, smoking status, blood lipids, HbA1c, creatinine, and albumin, indicating that the predictive ability of glucuronic acid for mortality is independent of these existing markers and their related biological mechanisms [34]. Moreover, we have demonstrated novel associations between glucuronic acid levels and future healthspan-related outcomes, including physical abilities, functional capabilities, and self-rated health, suggesting that the risk of mortality associated with elevated glucuronic acid levels is accompanied by a general decline in healthspan.…”

Section: Discussionmentioning

confidence: 99%

Circulating glucuronic acid predicts healthspan and longevity in humans and mice

Ho¹,

Sinick²,

Esko

et al. 2019

Aging

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Glucuronic acid is a metabolite of glucose that is involved in the detoxification of xenobiotic compounds and the structure/remodeling of the extracellular matrix. We report for the first time that circulating glucuronic acid is a robust biomarker of mortality that is conserved across species. We find that glucuronic acid levels are significant predictors of all-cause mortality in three population-based cohorts from different countries with 4-20 years of follow-up (HR=1.44, p=2.9×10-6 in the discovery cohort; HR=1.13, p=0.032 and HR=1.25, p=0.017, respectively in the replication cohorts), as well as in a longitudinal study of genetically heterogenous mice (HR=1.29, p=0.018). Additionally, we find that glucuronic acid levels increase with age and predict future healthspan-related outcomes. Together, these results demonstrate glucuronic acid as a robust biomarker of longevity and healthspan.

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MortalityPredictors.org: a manually-curated database of published biomarkers of human all-cause mortality

Cited by 8 publications

References 34 publications

Association of Extracellular Vesicle Protein Cargo with Race and Clinical Markers of Mortality

Association of Extracellular Vesicle Protein Cargo with Race and Clinical Markers of Mortality

Biomarkers, shock index and modified early warning score among older medical hospital inpatients in Nigeria

Circulating glucuronic acid predicts healthspan and longevity in humans and mice

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