MortalityPredictors.org: a manually-curated database of published biomarkers of human all-cause mortality

Abstract

Biomarkers of all-cause mortality are of tremendous clinical and research interest. Because of the long potential duration of prospective human lifespan studies, such biomarkers can play a key role in quantifying human aging and quickly evaluating any potential therapies. Decades of research into mortality biomarkers have resulted in numerous associations documented across hundreds of publications. Here, we present MortalityPredictors.org, a manually-curated, publicly accessible database, housing published, statistically-significant relationships between biomarkers and all-cause mortality in population-based or generally healthy samples. To gather the information for this database, we searched PubMed for appropriate research papers and then manually curated relevant data from each paper. We manually curated 1,576 biomarker associations, involving 471 distinct biomarkers. Biomarkers ranged in type from hematologic (red blood cell distribution width) to molecular (DNA methylation changes) to physical (grip strength). Via the web interface, the resulting data can be easily browsed, searched, and downloaded for further analysis. MortalityPredictors.org provides comprehensive results on published biomarkers of human all-cause mortality that can be used to compare biomarkers, facilitate meta-analysis, assist with the experimental design of aging studies, and serve as a central resource for analysis. We hope that it will facilitate future research into human mortality and aging.

Association of Extracellular Vesicle Protein Cargo with Race and Clinical Markers of Mortality

“…Many clinical measures are associated with all-cause mortality or predict risk of mortality including C-reactive protein (CRP) 16 , red cell distribution width (RDW) 17 , homeostatic model assessment insulin resistance (HOMA-IR) 18 , growth differential factor 15 (GDF15; also known as MIC-1) 19,20 , total white blood cell (WBC) count 21 , serum albumin 22 , serum alkaline phosphatase (ALP), estimated glomerular filtration rate (eGFR), mean cell volume (MCV), triglycerides, cholesterol, elevated blood pressure and elevated body mass index (BMI) 23 . Although progress has been made in identifying and documenting the use of clinical mortality markers, examination of EVs and their cargo in a middle-aged, racially diverse cohort as novel biomarkers of mortality risk could be useful to enhance identification of those at highest risk.…”

Biomarkers, shock index and modified early warning score among older medical hospital inpatients in Nigeria

“…2 Clinical applications of biomarkers generally include prognosticating for individual older patients, identifying high-risk older patients during hospitalisation and helping healthcare workers decide on the best treatment options. 15,16 In this study, we found low systolic blood pressure (SBP < 120 mmHg) and elevated temperature (≥ 39.0°C) to be the independent predictors of all-cause mortality among older medical hospital inpatients.…”

Circulating glucuronic acid predicts healthspan and longevity in humans and mice

“…The effect size of the relationship with mortality (hazard ratios between 1.1 and 1.4 in our cohorts) is comparable to that of existing, clinically-important biomarkers of mortality such as cholesterol (HR=1.12 per mmol/L increase) and systolic blood pressure (HR=1.13 per 10 mm Hg increase) [32, 33]. Importantly, the predictive utility of glucuronic acid persists after adjustment for standard clinical covariates and other accepted predictors of mortality, including factors such as demographics, BMI, smoking status, blood lipids, HbA1c, creatinine, and albumin, indicating that the predictive ability of glucuronic acid for mortality is independent of these existing markers and their related biological mechanisms [34]. Moreover, we have demonstrated novel associations between glucuronic acid levels and future healthspan-related outcomes, including physical abilities, functional capabilities, and self-rated health, suggesting that the risk of mortality associated with elevated glucuronic acid levels is accompanied by a general decline in healthspan.…”