Morroniside on anti-inflammation activities in rats following acute myocardial infarction

Yu, Bangxing; Zhang, Guoxing; An, Yufeng; Wang, Wen

doi:10.4196/kjpp.2018.22.1.17

Cited by 24 publications

(13 citation statements)

References 25 publications

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“…Corni fructus , a component of ALWPs, has anti-inflammatory effects by suppressing COX-2 and iNOS levels through the downregulation of NF-κB binding activity in macrophages ( Sung et al, 2009 ). Morroniside is a major component of C. officinalis , a component of ALWPs, and reduces proinflammatory cytokine IL-6 and IL-1β levels in a rat model of acute myocardial infarction ( Yu et al, 2018 ). In addition, type 2 diabetic rats orally administered morroniside, a component of ALWPs, exhibit downregulated NF-κB activity in hepatic tissue ( Park et al, 2009 ).…”

Section: Discussionmentioning

confidence: 99%

An Aqueous Extract of Herbal Medicine ALWPs Enhances Cognitive Performance and Inhibits LPS-Induced Neuroinflammation via FAK/NF-κB Signaling Pathways

Lee

Joo

Nam

et al. 2018

Front. Aging Neurosci.

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Recent studies have shown that Liuwei Dihuang pills (LWPs) can positively affect learning, memory and neurogenesis. However, the underlying molecular mechanisms are not understood. In the present study, we developed ALWPs, a mixture of Antler and LWPs, and investigated whether ALWPs can affect neuroinflammatory responses. We found that ALWPs (500 mg/ml) inhibited lipopolysaccharide (LPS)-induced proinflammatory cytokine IL-1β mRNA levels in BV2 microglial cells but not primary astrocytes. ALWPs significantly reduced LPS-induced cell-surface levels of TLR4 to alter neuroinflammation. An examination of the molecular mechanisms by which ALWPs regulate the LPS-induced proinflammatory response revealed that ALWPs significantly downregulated LPS-induced levels of FAK phosphorylation, suggesting that ALWPs modulate FAK signaling to alter LPS-induced IL-1β levels. In addition, treatment with ALWPs followed by LPS resulted in decreased levels of the transcription factor NF-κB in the nucleus compared with LPS alone. Moreover, ALWPs significantly suppressed LPS-induced BV2 microglial cell migration. To examine whether ALWPs modulate learning and memory in vivo, wild-type C57BL/6J mice were orally administered ALWPs (200 mg/kg) or PBS daily for 3 days, intraperitoneally injected (i.p.) with LPS (250 μg/kg) or PBS, and assessed in Y maze and NOR tests. We observed that oral administration of ALWPs to LPS-injected wild-type C57BL/6J mice significantly rescued short- and long-term memory. More importantly, oral administration of ALWPs to LPS-injected wild-type C57BL/6J mice significantly reduced microglial activation in the hippocampus and cortex. Taken together, our results suggest that ALWPs can suppress neuroinflammation-associated cognitive deficits and that ALWPs have potential as a drug for neuroinflammation/neurodegeneration-related diseases, including Alzheimer’s disease (AD).

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Section: Discussionmentioning

confidence: 99%

An Aqueous Extract of Herbal Medicine ALWPs Enhances Cognitive Performance and Inhibits LPS-Induced Neuroinflammation via FAK/NF-κB Signaling Pathways

Lee

Joo

Nam

et al. 2018

Front. Aging Neurosci.

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“…Loganin had a protective effect against hepatic oxidative stress [12]. Morroniside showed effective anti-inflammatory properties in AMI rats [13]. Sweroside could ameliorate liver injury by decreasing oxidative damage and inhibiting the production of proinflammatory kinases [14, 15].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects

Niu

Guo

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Wine processing is a specialized technology which involves sautéing crude herbal medicine using Chinese rice wine. Herein, we identified the changes in chemical profiles and antidiabetic effects of Corni Fructus (CF) after wine processing in high-fat diet (HFD) streptozotocin- (STZ-) induced diabetic mice. A novel high-efficiency method for simultaneously quantifying gallic acid, 5-hydroxymethylfurfural, morroniside, loganin, sweroside, and cornuside by UPLC was developed, and validating crude and wine-processing CF was done for the first time. Mice were randomly divided into the following groups and orally given different solutions for 4 weeks: normal group (NC, 0.4% (w/v) CMC-Na), model group (DM, 0.4% (w/v) CMC-Na), crude CF group (CP, 3.87 g/kg), and wine-processing CF group (PP, 3.87 g/kg) followed by HFD and multiple subcutaneous injection of STZ (40 mg/kg) to induce the diabetes model except the NC group. Biochemical indexes (body weight, fasting blood glucose level, lipid level, insulin, and free fatty acid) and other parameters involving liver toxicity were measured with commercial kits and immunohistochemical method. Comparative studies on pharmacology showed that the crude extracts possess higher efficacy on hypoglycemia and hypolipidemia, while wine-processing products exhibit better effects on liver preservation. Our data suggested that wine processing was recommended when CF was used for protecting the liver; however, crude products should be used as antidiabetic drugs.

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“…It was reported that AMI can lead to necrosis and initiate chronic cardiac dysfunction and pathological cardiac remodelling [4]. Although there are advances in the treatment of AMI, the irreversible loss of cardiomyocytes still leads to left ventricular remodeling and ischemic heart failure [5]. Therefore, it is vital to identify novel therapeutic drugs for the treatment of AMI.…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective effects of the total flavonoids of <i>Polygonum cuspidatum</i> Sieb. et Zucc. Root extract on experimental myocardial infarction in mice

Yu¹,

Jiang²,

Dong³

2019

Trop. J. Pharm Res

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Purpose: To study the cardioprotective effects of the total flavonoids from the roots of Polygonum cuspidatum Sieb. et Zucc. (FHZ) on experimental myocardial infarction in mice. Methods: Ultrasonic-assisted extraction of FHZ was optimized by response surface methodology (RSM) to obtain a higher extraction yield. Myocardial infarction (MI) was established by ligation of the left anterior descending (LAD) branch of the coronary artery in mice. Cardiac troponin T (cTnT), creatine phosphokinase (CPK), lactate dehydrogenase (LDH), lipid peroxide (LPO), malondialdehyde (MDA) and superoxide dismutase (SOD) levels in the serum of mice were assessed by enzyme-linked immunosorbent assay. Furthermore, myocardial infarction size (MIS) was examined by Masson's Trichrome staining on heart tissues. Results: Optimum extraction conditions of FHZ were as follows: an ethanol concentration of 69.03 %, a liquid-solid ratio of 27.14 g/mL and an extraction time of 30.30 min. The obtained extraction conditions were proven to be accurate and reliable. After treatment with FHZ for 3 and 7 days, the serum level of cTnT in MI mice decreased significantly. Also, the serum levels of CPK, LPO, MDA, and LDH were significantly decreased while SOD level increased in MI mice treated with FHZ. Furthermore, after treatment with FHZ for two weeks, the MIS of MI mice decreased (p < 0.01). Conclusion: RSM is a useful tool to optimize the ultrasonic-assisted extraction conditions for FHZ. Furthermore, FHZ possesses significant cardioprotective effects on experimental myocardial infarction in mice and thus may find application in the clinical management of myocardial infarction.

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Morroniside on anti-inflammation activities in rats following acute myocardial infarction

Cited by 24 publications

References 25 publications

An Aqueous Extract of Herbal Medicine ALWPs Enhances Cognitive Performance and Inhibits LPS-Induced Neuroinflammation via FAK/NF-κB Signaling Pathways

An Aqueous Extract of Herbal Medicine ALWPs Enhances Cognitive Performance and Inhibits LPS-Induced Neuroinflammation via FAK/NF-κB Signaling Pathways

Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects

Cardioprotective effects of the total flavonoids of <i>Polygonum cuspidatum</i> Sieb. et Zucc. Root extract on experimental myocardial infarction in mice

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