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“…Compared with the Kupffer cells and lymphocytes, the number of megakaryocytes in the fetuses of groups receiving citalopram at a dose of 10 or 20 mg/kg/day during the pregnancy did not change significantly. In view of the fact that megakaryocytes are responsible for the production of blood thrombocytes (platelets),[18] their unchanged number indicates that the hematopoietic role of the liver is not influenced by citalopram or its metabolites.…”
Section: Discussionmentioning
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“…Compared with the Kupffer cells and lymphocytes, the number of megakaryocytes in the fetuses of groups receiving citalopram at a dose of 10 or 20 mg/kg/day during the pregnancy did not change significantly. In view of the fact that megakaryocytes are responsible for the production of blood thrombocytes (platelets),[18] their unchanged number indicates that the hematopoietic role of the liver is not influenced by citalopram or its metabolites.…”
Section: Discussionmentioning
“…This alteration may indicate an oxidative stress on the bone marrow and vascular endothelial traumatic injury induced by Ag NMs. Megakaryocytes play an essential role in the synthesis of blood platelets and may indicate stress on haematopoiesis (Pacheco et al, 2002).…”
Section: Hepatic Histological Alterationsmentioning