Morphometry of megakaryocytes in the liver of New Zealand White rabbits during intrauterine and postnatal development

Pacheco, Maria Rita; Ferreira, Nilson; Melo, Valder Rodrigues de; Baraldi-Artoni, Silvana Martinez; Orsi, Antônio Marcos; Machado, Márcia Rita Fernandes; Oliveira, Fabrício Singaretti de

doi:10.1590/s0103-84782002000600015

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Compared with the Kupffer cells and lymphocytes, the number of megakaryocytes in the fetuses of groups receiving citalopram at a dose of 10 or 20 mg/kg/day during the pregnancy did not change significantly. In view of the fact that megakaryocytes are responsible for the production of blood thrombocytes (platelets),[18] their unchanged number indicates that the hematopoietic role of the liver is not influenced by citalopram or its metabolites.…”

Section: Discussionmentioning

confidence: 99%

Histological changes in the liver of fetuses of pregnant rats following citalopram administration

et al. 2013

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Objective:Depression is a dilapidating disorder, which may occur during pregnancy. Citalopram is an antidepressant drug often prescribed to pregnant women. The purpose of the present study is to determine whether maternal administration of citalopram affects fetal liver histology.Materials and Methods:Pregnant Wistar albino rats were treated with citalopram (10 or 20 mg/kg/day). A control group received no treatment. Rat fetal liver samples were obtained on day 18 of gestation and evaluated morphologically and histologically.Results:Statistical evaluation of data showed that there were no differences in liver weight and relative liver weight between control and citalopram treatment groups. Liver histology changes (such as increases in the number of Kupffer cells and lymphocytes) were seen in the fetuses of the group receiving a high dose of citalopram during gestation. Degeneration of hepatocytes was not seen and the megakaryocyte number did not change significantly in the citalopram treated groups.Conclusion:This study showed that citalopram administration during gestation may have some adverse effects on the phagocytic cell population in the fetal liver of rats.

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Section: Discussionmentioning

confidence: 99%

Histological changes in the liver of fetuses of pregnant rats following citalopram administration

et al. 2013

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“…This alteration may indicate an oxidative stress on the bone marrow and vascular endothelial traumatic injury induced by Ag NMs. Megakaryocytes play an essential role in the synthesis of blood platelets and may indicate stress on haematopoiesis (Pacheco et al, 2002).…”

Section: Hepatic Histological Alterationsmentioning

confidence: 99%

In vivo study of silver nanomaterials’ toxicity with respect to size

et al. 2020

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Silver nanoparticles (Ag NPs) are widely used in nanomedicine, pharmaceutical products, industry and other consumer products owing to their unique physiochemical properties with probable potential risk to human health and the ecosystems. The aim of this work was to investigate the in-life morphological effects, biochemical, histological and histochemical alterations that might be induced by variable sizes of Ag NPs in hepatic, renal and testicular tissues with the hypothesis that variable sizes of nano-Ag could induce variable effects in the vital organs. Five groups of adult healthy male mice (BALB/C) were exposed to 35 intraperitoneal injections of Ag NPs (1 mg/kg bw) using five different particle sizes (10, 20, 40, 60 and 100 nm). All mice were subjected to in-life morphometric, biochemical, histological and histochemical analysis. The findings demonstrated that Ag NPs could induce alterations in the average body weight gain, food consumption, water intake and organ indices. In addition, these NPs significantly altered hepatic and renal biomarkers. Moreover, Ag NPs produced ground glass hepatocyte cytoplasm, with mitotic activity, nuclear alterations, degeneration, glycogen depletion and inflammatory cells infiltration in the liver. The kidneys of treated mice exhibited proximal renal tubules degeneration, distal renal tubules regeneration, glomerular shrinkage, Bowman’s capsule thickening and interstitial inflammation. The testicular tissues demonstrated spermatocyte sloughing and spermatid giant cell formation. The findings together indicated that Ag NPs could interact with the anatomical structures of the liver, kidney and testis in ways that could induce injury. In addition, the results indicated that smaller Ag NPs posed a greater potential risk than the larger ones, which might be associated with their behaviour, dissolution rate, bioavailability and their probable variable toxicokinetics.

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Haematopoietic thrombocyte precursors in rat femoral and sternal bone marrow

Suljević¹,

Hamzic²,

Islamagić³

et al. 2021

BJVM

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This research presents the first findings on thrombopoiesis for Wistar rats. Haemopoietic cells from the femur and the sternum were analysed by light microscopy in combination with infrared and near-ultraviolet light for fine cytoplasmic structure analysis. Five main types of thrombocyte precursor cells were identified in the bone marrow samples: megakaryoblast, promegakaryocyte and megakaryocyte (basophilic, acidophilic and thrombocytogenic). More intensive thrombopoiesis and morphologically differentiated cells were found in sternum samples.

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Morphometry of megakaryocytes in the liver of New Zealand White rabbits during intrauterine and postnatal development

Abstract: SUMMARY The hepatic megakaryocytic cells of New Zealand

Cited by 3 publications

References 9 publications

Histological changes in the liver of fetuses of pregnant rats following citalopram administration

Histological changes in the liver of fetuses of pregnant rats following citalopram administration

In vivo study of silver nanomaterials’ toxicity with respect to size

Haematopoietic thrombocyte precursors in rat femoral and sternal bone marrow

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