Morphometric Analysis of Macular Photoreceptors and Ganglion Cells in Retinas With Retinitis Pigmentosa

Pattern-reversal electroretinograms and visual evoked potentials in retinitis pigmentosa

“…None of the RP patients displayed normal PERGs, and recordable, reproducible PERGs were obtained from only 32% of them. This proportion correlates well with the findings of an earlier PERG study [19] and with the results of the histological studies by Santos et al [3] and Stone et al [4], who observed a 50-75% reduction in the number of macular ganglion cells. The rather low percentage of successful recordings of PERGs diminishes the utility of this method in the clinical follow-up of RP patients.…”

“…The extinguished PERGs of patients with RP are in line with the ganglion cell loss revealed in the macula by histological studies [4]. It seems interesting that, besides the severely damaged or almost extinguished PERGs many of the PVEPs were well preserved.…”

Pattern-reversal electroretinograms and visual evoked potentials in retinitis pigmentosa

“…None of the RP patients displayed normal PERGs, and recordable, reproducible PERGs were obtained from only 32% of them. This proportion correlates well with the findings of an earlier PERG study [19] and with the results of the histological studies by Santos et al [3] and Stone et al [4], who observed a 50-75% reduction in the number of macular ganglion cells. The rather low percentage of successful recordings of PERGs diminishes the utility of this method in the clinical follow-up of RP patients.…”

“…The extinguished PERGs of patients with RP are in line with the ganglion cell loss revealed in the macula by histological studies [4]. It seems interesting that, besides the severely damaged or almost extinguished PERGs many of the PVEPs were well preserved.…”

Evaluation of patient suitability for a retinal prosthesis using structural and functional tests of inner retinal integrity

“…Outer retinal layer degeneration in RP is well documented [6,7,17] and a reduction in thickness as measured by OCT has been found to be linked to foveal photoreceptor loss [17]. Outer retinal thickness reductions in the macula and peripheral retina found in this study support these findings from previous research, including the post-mortem morphometric studies [6][7][8].…”

Evaluation of residual retinal function by pupillary constrictions and phosphenes using transcorneal electrical stimulation in patients with retinal degeneration

“…2). These results indicate that in the former group, the rate of RGC loss in macula area may be similar to that in the extramacular area as reported [9,27,29], while in the latter group, the degree of RGC loss in the macula may be higher than that in the extramacular area. 5 Comparison of mean thresholds of RP patients with those of CRD patients.…”

Pattern-reversal electroretinograms and visual evoked potentials in retinitis pigmentosa

“…None of the RP patients displayed normal PERGs, and recordable, reproducible PERGs were obtained from only 32% of them. This proportion correlates well with the findings of an earlier PERG study [19] and with the results of the histological studies by Santos et al [3] and Stone et al [4], who observed a 50-75% reduction in the number of macular ganglion cells. The rather low percentage of successful recordings of PERGs diminishes the utility of this method in the clinical follow-up of RP patients.…”

“…The extinguished PERGs of patients with RP are in line with the ganglion cell loss revealed in the macula by histological studies [4]. It seems interesting that, besides the severely damaged or almost extinguished PERGs many of the PVEPs were well preserved.…”

Evaluation of patient suitability for a retinal prosthesis using structural and functional tests of inner retinal integrity

“…Outer retinal layer degeneration in RP is well documented [6,7,17] and a reduction in thickness as measured by OCT has been found to be linked to foveal photoreceptor loss [17]. Outer retinal thickness reductions in the macula and peripheral retina found in this study support these findings from previous research, including the post-mortem morphometric studies [6][7][8].…”

Evaluation of residual retinal function by pupillary constrictions and phosphenes using transcorneal electrical stimulation in patients with retinal degeneration

“…2). These results indicate that in the former group, the rate of RGC loss in macula area may be similar to that in the extramacular area as reported [9,27,29], while in the latter group, the degree of RGC loss in the macula may be higher than that in the extramacular area. 5 Comparison of mean thresholds of RP patients with those of CRD patients.…”

Pattern-reversal electroretinograms and visual evoked potentials in retinitis pigmentosa

“…None of the RP patients displayed normal PERGs, and recordable, reproducible PERGs were obtained from only 32% of them. This proportion correlates well with the findings of an earlier PERG study [19] and with the results of the histological studies by Santos et al [3] and Stone et al [4], who observed a 50-75% reduction in the number of macular ganglion cells. The rather low percentage of successful recordings of PERGs diminishes the utility of this method in the clinical follow-up of RP patients.…”

“…The extinguished PERGs of patients with RP are in line with the ganglion cell loss revealed in the macula by histological studies [4]. It seems interesting that, besides the severely damaged or almost extinguished PERGs many of the PVEPs were well preserved.…”

Evaluation of patient suitability for a retinal prosthesis using structural and functional tests of inner retinal integrity

“…Outer retinal layer degeneration in RP is well documented [6,7,17] and a reduction in thickness as measured by OCT has been found to be linked to foveal photoreceptor loss [17]. Outer retinal thickness reductions in the macula and peripheral retina found in this study support these findings from previous research, including the post-mortem morphometric studies [6][7][8].…”

Evaluation of residual retinal function by pupillary constrictions and phosphenes using transcorneal electrical stimulation in patients with retinal degeneration

“…2). These results indicate that in the former group, the rate of RGC loss in macula area may be similar to that in the extramacular area as reported [9,27,29], while in the latter group, the degree of RGC loss in the macula may be higher than that in the extramacular area. 5 Comparison of mean thresholds of RP patients with those of CRD patients.…”