Morphology of colorectal lymphoid aggregates in cancer, diverticular and inflammatory bowel diseases

Nascimbeni, Riccardo; Fabio, Francesco Di; Betta, Ernesto Di; Mariani, Pier Paolo; Fisogni, Simona; Villanacci, Vincenzo

doi:10.1038/modpathol.3800343

Cited by 31 publications

(22 citation statements)

References 14 publications

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“…Overall, our results indicate that unaffected gastrointestinal tract tissue of CD patients differs from that of healthy controls. Our finding of deregulated cytokine production, together with the Nascimbeni et al observation of formation of lymphoid aggregates in unaffected tissues, address a possible important role in the disease pathology (50). In the present study we show general reduction in MDR1 expression in CD.…”

Section: Expression Of Cytokines and Socs Moleculessupporting

confidence: 69%

Reduction of MDR1, MRP1 and BCRP expression in Crohn’s disease: a role in disease pathogenesis?

et al. 2015

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Background and purpose: ABC transporters have a non-redundant role in the maintenance of gut homeostasis and changes in their expressionIntroductIon C rohn's disease (CD) is a chronic intestinal bowel disorder (IBD) of unknown cause in which genetic and environmental factors, primarily microbial, influence the gastrointestinal tract's ability to balance pro-and anti-inflammatory mechanisms. The immunopathology is driven by innate cytokines like TNF-a, IL-6 and IL-1b that are responsible for the chemokine release and neutrophil infiltration. Their production is elevated in CD and they contribute to tissue damage directly or indirectly through elevation of matrix metalloproteinases (1-3). Presence of elevated expression and production of cytokines like IFN-g and IL-17, produced by CD4 Th1 and Th17 effector T cells, implicate an ongoing adaptive immune response in the CD (4, 5).

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Section: Expression Of Cytokines and Socs Moleculessupporting

confidence: 69%

Reduction of MDR1, MRP1 and BCRP expression in Crohn’s disease: a role in disease pathogenesis?

et al. 2015

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“…Density and characteristics of lymphoid aggregates have been assessed histologically according to a method described previously 5 . Briefly, one or two full-thickness rectangular strips (2 × 1 cm) of normal-appearing ascending colon were obtained from the distal border of each surgical specimen immediately after resection.…”

Section: Immunohistologymentioning

confidence: 99%

Colonic lymphoid follicles and NOD2/CARD15 mutational status in Crohn's disease

Nascimbeni¹,

Villanacci

Bassotti

et al. 2009

British Journal of Surgery

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“…To date, only few data are available on colonic lymphoid aggregates (CLA) in response to intestinal diseases in humans [1][2][3], and most are pertinent to patients with inflammatory bowel diseases [4][5][6]. However, almost all investigations were performed in patients with inflammatory conditions of the colon, and most "normal" data have been obtained from necropsy specimens [7][8].…”

Section: Abstract Colon Constipation Lymphoid Aggregatesmentioning

confidence: 99%

“…Sigmoid sample were obtained to have a better comparison with the control group. However, a previous study of ours showed there is no difference in number and diameter of CLA among the right colon, the left colon, and the rectum [6]. Each strip was fixed in 10% buffered formalin and paraffin-embedded.…”

Section: Ethical Considerationsmentioning

confidence: 99%

Colonic Lymphoid Aggregates in Slow Transit Constipation

et al. 2007

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Information available on colonic lymphoid aggregates, apart from data of patients with inflammatory conditions, is scarce in other pathologic conditions. We investigated colonic lymphoid aggregates in patients with severe slow transit constipation, unresponsive to conventional therapeutic measures, and undergoing surgery for relief of their symptoms. Tissues from 27 patients with intractable slow transit constipation were obtained and compared with 10 controls. The number, diameter, lymphocyte distribution, and proliferative index were calculated and compared in both groups. Constipated patients displayed a significantly increased number of colonic lymphoid aggregates compared with controls. No differences were found concerning the other variables. The increase of colonic lymphoid aggregates found in severely constipated patients may represent a protective mucosal mechanism toward the chronic fecal stasis.

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Morphology of colorectal lymphoid aggregates in cancer, diverticular and inflammatory bowel diseases

Cited by 31 publications

References 14 publications

Reduction of MDR1, MRP1 and BCRP expression in Crohn’s disease: a role in disease pathogenesis?

Reduction of MDR1, MRP1 and BCRP expression in Crohn’s disease: a role in disease pathogenesis?

Colonic lymphoid follicles and NOD2/CARD15 mutational status in Crohn's disease

Colonic Lymphoid Aggregates in Slow Transit Constipation

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