Morphological characteristics of malignant T-cell lymphomas in baboons

Yakovleva, L. A.; Lennert, K.; Chikobava, M. G.; Indzhiia, L V; Klotz, Igor N.; Лапин, Б. А.

doi:10.1007/bf01607162

Cited by 9 publications

(4 citation statements)

References 25 publications

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“…In baboons, the age at onset ranged from three to 20 years old, while the STLV-infected baboons with NHL ranged in age from three to 21 years (mean, 13 years) 5 . The morphological characteristics of the dominant neoplastic cells of peripheral T-cell NHL in baboons with STLV-1 infections showed four morphological phenotypes of neoplastic cells: lymphocytic, prolymphocytic-lymphocytic, immunoblastic and large anaplastic 6 . In lymphocytic and prolymphocytic-lymphocytic lymphomas, high endothelial venules and epithelioid cells were also seen.…”

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confidence: 97%

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Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset (<i>Callithrix jacchus</i>)

et al. 2013

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We histopathologically and immunohistochemically investigated a case of malignant lymphoma that spontaneously developed in a male common marmoset at two years of age. Beginning at two years four months of age, the animal had an enlargement of the submandibular and inguinal lymph nodes, small subcutaneous nodules near the right breast and an approximately fivefold increase in peripheral lymphocyte count compared with the previous examination value. The postmortem findings at two years eight months of age showed lymphadenopathy with enlargement of the thymus and spleen. Small- to intermediate-sized neoplastic lymphocytes had diffusely proliferated in the enlarged nodes. The neoplastic cells were pleomorphic and had irregularly shaped nuclei. The nuclear chromatin staining revealed hyperchromatism in the small-sized cells, and the intermediate-sized cells exhibited vesicular staining. An immunohistochemical examination indicated that the neoplastic lymphocytes were positive for CD3 and negative for CD20, thus suggesting that they had originated from T cells. In addition, the proliferation of high endothelial venules and reactive epithelioid histiocytes was observed. Scattered tingible body-laden macrophages were infrequently detected. Neoplastic lymphocytes were also observed in the thymus, spleen, heart, lungs, liver, kidneys, adrenal glands and femoral and sternal bone marrow. This malignant lymphoma in a young male common marmoset was considered to fit the category of “peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)” according to the new WHO system of classification.

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“…Spontaneous lymphoma has been reported in nonhuman primates, such as anthropoid apes 1 , gibbons 2 , 3 , 4 , baboons 5 , 6 , and macaques 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 . On the other hand, there have been a few of reports about lymphoma in “new world primates” 15 , 16 , 17 , 18 .…”

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Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset (<i>Callithrix jacchus</i>)

et al. 2013

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“…The virus is endemic in many captive colonies. Simian T‐lymphotropic virus causes cutaneous lymphomas in Old World monkeys and apes 2,98 . There is active National Institutes of Health support for the establishment of research colonies free of these viruses because they confound experimental work.…”

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Nonhuman primate dermatology: a literature review

Bernstein¹,

Didier

2009

Veterinary Dermatology

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In general, veterinary dermatologists do not have extensive clinical experience of nonhuman primate (NHP) dermatoses. The bulk of the published literature does not provide an organized evidence-based approach to the NHP dermatologic case. The veterinary dermatologist is left to extract information from both human and veterinary dermatology, an approach that can be problematic as it forces the clinician to make diagnostic and therapeutic decisions based on two very disparate bodies of literature. A more cohesive approach to NHP dermatology – without relying on assumptions that NHP pathology most commonly behaves similarly to other veterinary and human disease – is required. This review of the dermatology of NHP species includes discussions of primary dermatoses, as well as diseases where dermatologic signs represent a significant secondary component, provides a first step towards encouraging the veterinary community to study and report the dermatologic diseases of nonhuman primates.

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“…For detecting the possible biomolecular differences between the viruses isolated in the control and lymphomatous groups, we compared sequenced fragments of STLV-1 from lymphomatous baboons (STLV-1PhL) and healthy carriers (STLV-1PhN) in the control group. Different degree of homology with HTLV-1 and between STLV-1PhL and STLV-1PhN was detected in the sequenced env and tax sites [7,10]. The forest variant of STLV-1PhN had 96% homology with HTLV-1 and only 83% with STLV-1PhL.…”

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Differences in STLV-1 genome structure in baboons dead from malignant lymphoma in various chronological periods of a many-year outbreak of the disease

et al. 1999

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The fragments of simian retrovirus genome STLV-1Ph detected in lymphomatous specimens from baboons dead from malignant lymphoma in different periods of a many-year (22 years) outbreak are studied. African and Asian subtypes of STLV-1Ph retrovirus circulate in the animals: the African type predominates during the first and Asian during the second half of the outbreak.Key Words: baboons; outbreak of malignant lymphoma; STL V-1Ph retrovirus; African and Asian subtypes Many-year (1967Many-year ( -1991 outbreak of malignant lymphoma among baboons (primarily Papio hamadryas) in the Sukhumi Breeding Center began with inoculation of human leukemic material to several animals and led to death of almost 400 adult baboons [ 1 ]. A group of baboons at a high risk of lymphoma was formed including a total of 4158 animals over the entire period of experiment. Control group consisted of 800 baboons brought to the center and living at an isolated territory, which had no contacts with lymphomatous animals. No cases of lymphoma were detected in the control group during at least 15 years. Immunophenotypically, malignant lymphomas of baboons were identified as non-Hodgkin's lymphomas (NHL) of T or B cell similar to human tumors. Testing for STLV-1 in 68 cases of T-cell NHL by PCR showed that retrovirus can be present in all cytological variants of identified T-cell baboon lymphomas [3,11].Horizontal dissemination of lymphoma and the presence of type C retrovirus particles in lymphoid Department of Immunology and Oncovirology, Institute of Medical Primatolocjy, Russian Academy of Medical Sciences, Adler--Sochi cells, lungs, kidneys, and salivary glands of sick animals confirmed viral origin of lymphoma. In further studies the virus was identified as simian T-lymphotropic retrovirus (STLV-IPh or PTLV-1) [4,7] belonging to human HTLV-1 subfamily. Serum antibodies to STLV-1 were detected in 40-45% adult animals in the high-risk group and in almost 100% of baboons with T-cell malignant lymphomas [3]. Moreover, antibodies to STLV-1 were detected in the blood of 7% healthy adult animals in the control group. For detecting the possible biomolecular differences between the viruses isolated in the control and lymphomatous groups, we compared sequenced fragments of STLV-1 from lymphomatous baboons (STLV-1PhL) and healthy carriers (STLV-1PhN) in the control group. Different degree of homology with HTLV-1 and between STLV-1PhL and STLV-1PhN was detected in the sequenced env and tax sites [7,10]. The forest variant of STLV-1PhN had 96% homology with HTLV-1 and only 83% with STLV-1PhL. The data on the molecular structure of sequenced fragments of STLV-1/HTLV-1 were sufficient for phylogenetic analysis and grouping of viruses of this family into two 0007-4888/99/0007-0733522.00 9KluwerAcademic/PlenumPublishers

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Morphological characteristics of malignant T-cell lymphomas in baboons

Cited by 9 publications

References 25 publications

Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset (<i>Callithrix jacchus</i>)

Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset (<i>Callithrix jacchus</i>)

Nonhuman primate dermatology: a literature review

Differences in STLV-1 genome structure in baboons dead from malignant lymphoma in various chronological periods of a many-year outbreak of the disease

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