Morphological Characteristics of Brain Tumors Causing Seizures

Abstract

Objective-To quantify size and localization differences between tumors presenting with seizures vs nonseizure neurological symptoms.Design-Retrospective imaging survey. We performed magnetic resonance imaging-based morphometric analysis and nonparametric mapping in patients with brain tumors. Setting-University-affiliated teaching hospital.Patients or Other Participants-One hundred twenty-four patients with newly diagnosed supratentorial glial tumors.Main Outcome Measures-Volumetric and mapping methods were used to evaluate differences in size and location of the tumors in patients who presented with seizures as compared with patients who presented with other symptoms.Results-In high-grade gliomas, tumors presenting with seizures were smaller than tumors presenting with other neurological symptoms, whereas in low-grade gliomas, tumors presenting with seizures were larger. Tumor location maps revealed that in high-grade gliomas, deep-seated tumors in the pericallosal regions were more likely to present with nonseizure neurological symptoms. In low-grade gliomas, tumors of the temporal lobe as well as the insular region were more likely to present with seizures.Conclusions-The influence of size and location of the tumors on their propensity to cause seizures varies with the grade of the tumor. In high-grade gliomas, rapidly growing tumors, particularly those situated in deeper structures, present with non-seizure-related symptoms. In low-grade gliomas, lesions in the temporal lobe or the insula grow large without other symptoms

Seizure‐susceptible brain regions in glioblastoma: identification of patients at risk

“…However, most of these studies did not use a volumetric imaging analysis for precise localization of seizure-related regions. In contrast to our results, one retrospective volumetric study [16] (n = 67) in a mixed sample of high-grade gliomas reported that tumors located in corpus callosum, medial-anterior cingulate gyrus and caudate have a lower risk of seizures at onset while no brain region showed an increased seizure risk. These different results could be explained by the histological heterogeneity of the sample and the lack of consideration as a separate group of the analysis of patients who develop seizures during follow-up.…”

Seizure‐susceptible brain regions in glioblastoma: identification of patients at risk

“…However, most of these studies did not use a volumetric imaging analysis for precise localization of seizure-related regions. In contrast to our results, one retrospective volumetric study [16] (n = 67) in a mixed sample of high-grade gliomas reported that tumors located in corpus callosum, medial-anterior cingulate gyrus and caudate have a lower risk of seizures at onset while no brain region showed an increased seizure risk. These different results could be explained by the histological heterogeneity of the sample and the lack of consideration as a separate group of the analysis of patients who develop seizures during follow-up.…”

The Significance of IDH1 Mutations in Tumor‐Associated Seizure in 60 Chinese Patients with Low‐Grade Gliomas

“…This was probably because younger patients with less developed brains were more susceptible to epileptogenic activity than older patients [ 12 ]. In contrast to other early studies [ 8 , 10 – 12 ], we did not find that patients with gliomas of the temporal lobe and the oligodendroglial type (including oligodendroglioma and oligoastrocytoma hypotype) were more prone to suffering from epilepsies. The negative results may be, to some extent, due to the different standard of pathologic diagnosis in different institutions.…”

Correlation between tumor-related seizures and molecular genetic profile in 103 Chinese patients with low-grade gliomas: A preliminary study

“…In contrast to other previous studies [1,[5][6][7], unfortunately we did not find that tumors of the temporal lobe and oligodendroglioma and oligoastrocytoma subtypes are significantly more likely to present with seizures. These negative findings could be due to several reasons such as differences in study design, the study of different populations, and the relatively small number of tumors in our study.…”

Seizure‐susceptible brain regions in glioblastoma: identification of patients at risk

“…However, most of these studies did not use a volumetric imaging analysis for precise localization of seizure-related regions. In contrast to our results, one retrospective volumetric study [16] (n = 67) in a mixed sample of high-grade gliomas reported that tumors located in corpus callosum, medial-anterior cingulate gyrus and caudate have a lower risk of seizures at onset while no brain region showed an increased seizure risk. These different results could be explained by the histological heterogeneity of the sample and the lack of consideration as a separate group of the analysis of patients who develop seizures during follow-up.…”

The Significance of IDH1 Mutations in Tumor‐Associated Seizure in 60 Chinese Patients with Low‐Grade Gliomas

“…This was probably because younger patients with less developed brains were more susceptible to epileptogenic activity than older patients [ 12 ]. In contrast to other early studies [ 8 , 10 – 12 ], we did not find that patients with gliomas of the temporal lobe and the oligodendroglial type (including oligodendroglioma and oligoastrocytoma hypotype) were more prone to suffering from epilepsies. The negative results may be, to some extent, due to the different standard of pathologic diagnosis in different institutions.…”

Correlation between tumor-related seizures and molecular genetic profile in 103 Chinese patients with low-grade gliomas: A preliminary study

“…In contrast to other previous studies [1,[5][6][7], unfortunately we did not find that tumors of the temporal lobe and oligodendroglioma and oligoastrocytoma subtypes are significantly more likely to present with seizures. These negative findings could be due to several reasons such as differences in study design, the study of different populations, and the relatively small number of tumors in our study.…”

Seizure‐susceptible brain regions in glioblastoma: identification of patients at risk

“…However, most of these studies did not use a volumetric imaging analysis for precise localization of seizure-related regions. In contrast to our results, one retrospective volumetric study [16] (n = 67) in a mixed sample of high-grade gliomas reported that tumors located in corpus callosum, medial-anterior cingulate gyrus and caudate have a lower risk of seizures at onset while no brain region showed an increased seizure risk. These different results could be explained by the histological heterogeneity of the sample and the lack of consideration as a separate group of the analysis of patients who develop seizures during follow-up.…”

The Significance of IDH1 Mutations in Tumor‐Associated Seizure in 60 Chinese Patients with Low‐Grade Gliomas

“…This was probably because younger patients with less developed brains were more susceptible to epileptogenic activity than older patients [ 12 ]. In contrast to other early studies [ 8 , 10 – 12 ], we did not find that patients with gliomas of the temporal lobe and the oligodendroglial type (including oligodendroglioma and oligoastrocytoma hypotype) were more prone to suffering from epilepsies. The negative results may be, to some extent, due to the different standard of pathologic diagnosis in different institutions.…”

Correlation between tumor-related seizures and molecular genetic profile in 103 Chinese patients with low-grade gliomas: A preliminary study

“…In contrast to other previous studies [1,[5][6][7], unfortunately we did not find that tumors of the temporal lobe and oligodendroglioma and oligoastrocytoma subtypes are significantly more likely to present with seizures. These negative findings could be due to several reasons such as differences in study design, the study of different populations, and the relatively small number of tumors in our study.…”