Morphological change of left atrium in obese individuals

Ito, Keiichi; Date, Taro; Kikuchi, Makoto; Nojiri, Ayumi; Narui, Ryosuke; Hioki, Mika; Tanigawa, Shin‐ichi; Yamashita, Seigo; Tokuda, Michifumi; Inada, Keiichi; Matsuo, Seiichiro; Yamane, Teiichi; Yoshimura, Michihiro

doi:10.1016/j.ijcard.2011.07.037

Cited by 17 publications

(14 citation statements)

References 11 publications

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“…Interestingly, the dilatation appears to occur in a longitudinal direction more often than in a transverse direction, although it is unknown how this factor relates to AF onset. 27 The incidence and risk increases as the degree of obesity increases, and it is the LAD and not the obesity per se that correlates with the risk of AF. 28 In addition to LAD, higher epicardial fat mass is associated with the genesis of atrial arrhythmias in patients with or without heart failure, 29 although it appears that AF occurs at lower fat volumes in patients with heart failure.…”

Section: Atrial Fibrillation (Af)mentioning

confidence: 99%

Perioperative management of the severely obese patient: a selective pathophysiological review

Cullen

Ferguson

2012

Can J Anesth/J Can Anesth

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Section: Atrial Fibrillation (Af)mentioning

confidence: 99%

Perioperative management of the severely obese patient: a selective pathophysiological review

Cullen

Ferguson

2012

Can J Anesth/J Can Anesth

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“…Enlargement of the left atrium in obesity is a consequence of elevated plasma volume, increased preload and LV diastolic filling pressure, and represents 1 of the most studied precursors of AF due to structural and electrical remodeling of the left atrium. Previous studies showed that BMI is certainly 1 of the most important markers of atrial size and volume . In addition, the investigators revealed that each 1‐unit increase in BMI is associated with a 7% greater risk of permanent AF, a 4% greater risk of intermittent AF, and a 1% greater risk of transitory AF .…”

Section: Obesity and Waist Circumferencementioning

confidence: 99%

What Do We Currently Know About Metabolic Syndrome and Atrial Fibrillation?

Tadić

Ivanović

Cuspidi

2013

Clinical Cardiology

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Metabolic syndrome represents a cluster of atherogenic risk factors including hypertension, insulin resistance, obesity, and dyslipidemia. Considering that all of these risk factors could influence the development of atrial fibrillation, an association between atrial fibrillation and the metabolic syndrome has been suggested. Additionally, oxidative stress and inflammation have been involved in the pathogenesis of both metabolic syndrome and atrial fibrillation. The mechanisms that relate metabolic syndrome to the increased risk of atrial fibrillation occurrence are not completely understood. Metabolic syndrome and atrial fibrillation are associated with increased cardiovascular morbidity and mortality. Because atrial fibrillation is the most common arrhythmia, and along with the prevalence of metabolic syndrome constantly increasing, it would be very important to determine the relationship between these 2 entities, especially due to the fact that the risk factors of metabolic syndrome are mainly correctable. This review focused on the available evidence supporting the association between metabolic syndrome components and metabolic syndrome as a clinical entity with atrial fibrillation. IntroductionMetabolic syndrome (MS) represents a cluster of cardiovascular (CV) and metabolic derangements (ie, increased blood pressure, abdominal obesity, insulin resistance, and dyslipidemia), which deteriorate vascular function and cause subclinical damage in a variety of organs, more than traditional risk factors individually.1 Atrial fibrillation (AF) is certainly the most prevalent arrhythmia in everyday clinical practice, and its prevalence increases parallel to MS frequency. 2 Each of the MS components are related to increased risk for AF occurrence. However, the exact mechanisms of these relationships have not been studied enough. Because both of these conditions are associated with significant CV and cerebrovascular morbidity and mortality, it is important to assess the relationship between these 2 frequent conditions and to determine the mechanisms that connect them.For the purpose of this review article, we used PubMed, Medline, OVID, and EMBASE databases and searched for the studies published

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“…This is suggested by the observation that obesity is characterized by distinct deformation of the LA, resulting in an 'oval-shaped' morphology and dilated LA, which can contribute to AF susceptibility in obese individuals. 78 Low-grade inflammation, increased activity of renin -angiotensin -aldosterone system, and high plasma levels of endothelin and TGF-b1 can contribute to the progression of the substrate of AF in obese patients. 79 Experimental studies have clearly demonstrated a direct and specific impact of obesity on the atria and on progression of AF substrate.…”

Section: The Paradigm Of Obesitymentioning

confidence: 99%

Cardiac adipose tissue and atrial fibrillation: the perils of adiposity

2016

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The amount of adipose tissue that accumulates around the atria is associated with the risk, persistence, and severity of atrial fibrillation (AF). A strong body of clinical and experimental evidence indicates that this relationship is not an epiphenomenon but is the result of complex crosstalk between the adipose tissue and the neighbouring atrial myocardium. For instance, epicardial adipose tissue is a major source of adipokines, inflammatory cytokines, or reactive oxidative species, which can contribute to the fibrotic remodelling of the atrial myocardium. Fibro-fatty infiltrations of the subepicardium could also contribute to the functional disorganization of the atrial myocardium. The observation that obesity is associated with distinct structural and functional remodelling of the atria has opened new perspectives of treating AF substrate with aggressive risk factor management. Advances in cardiac imaging should lead to an improved ability to visualize myocardial fat depositions and to localize AF substrates.

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Morphological change of left atrium in obese individuals

Cited by 17 publications

References 11 publications

Perioperative management of the severely obese patient: a selective pathophysiological review

Perioperative management of the severely obese patient: a selective pathophysiological review

What Do We Currently Know About Metabolic Syndrome and Atrial Fibrillation?

Cardiac adipose tissue and atrial fibrillation: the perils of adiposity

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