Morphologic features of the fetal mandibular condyle: Layers, canals and microvascular pattern

Rusu, Mugurel Constantin; Pop, F.; Leonardi, Rosalia; Motoc, Andrei Gheorghe Marius; Jianu, Adelina Maria

doi:10.1016/j.aanat.2011.03.006

Cited by 9 publications

(14 citation statements)

References 22 publications

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“…Rusu et al () also reported detailed observations of condylar cartilage in third trimester human fetuses and described the variation of VCs in their distribution and architecture. They observed extrinsic vessels that entered the cartilage through VCs and intrinsic vessels from the erosive zone, which ascended through VCs.…”

Section: Discussionmentioning

confidence: 98%

“…The VCs in the present study seemed to correspond to their VCs containing intrinsic vessels, although we did not observe extrinsic vessels in the condylar cartilage of midterm fetuses. This is due to the gestational age examined, since VCs containing extrinsic vessels are frequently observed in condylar cartilage of third trimester fetuses or young infants (Blackwood, ; Morimoto et al, ; Rusu et al, ). Rusu et al () also distinguished VCs containing mesenchymal‐vascular content, expanded from the erosive vascular mesenchymal layer, from the “fibrous content” connected to the fibrous articular layer.…”

Section: Discussionmentioning

confidence: 99%

“…This is due to the gestational age examined, since VCs containing extrinsic vessels are frequently observed in condylar cartilage of third trimester fetuses or young infants (Blackwood, ; Morimoto et al, ; Rusu et al, ). Rusu et al () also distinguished VCs containing mesenchymal‐vascular content, expanded from the erosive vascular mesenchymal layer, from the “fibrous content” connected to the fibrous articular layer. As vascular remnants are identified in some of the canals containing fibrous expansion of the fibrous articular layer, they termed those canals “fibrovascular canals”.…”

Section: Discussionmentioning

confidence: 99%

“…Further, the deepest posterolateral VC was completely surrounded by the hypertrophic chondrocytes at 12–13 weeks gestation. After detailed topographic observation of condylar cartilage in third trimester human fetuses Rusu et al () reported that VCs may be present on its entire sagittal length, deepening variably towards the erosive zone and opening superiorly in the “loose layer” covering the condylar cartilage. They further discriminated VCs containing extrinsic vessels from those containing intrinsic vessels.…”

mentioning

confidence: 99%

“…The function of VCs in condylar cartilage is to increase nutrition of the cartilage during a period of rapid growth (Blackwood, ), as well as to be involved in condylar growth via endochondral ossification (Blackwood, ; Rusu et al, ). In addition, the persistence of VCs may give rise to a bifid mandibular condyle (Morimoto et al, ; Rusu et al, ), and hence, it is important to understand features of VCs in clinical fields. These studies indicate that the distribution and structure of VCs vary in position and fetal age.…”

mentioning

confidence: 99%

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An Immunohistochemical Study of Matrix Components in Early‐Stage Vascular Canals Within Mandibular Condylar Cartilage in Midterm Human Fetuses

Shibata

Morita

Yokohama-Tamaki

et al. 2015

The Anatomical Record

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Matrix components of vascular canals (VCs) in human fetal mandibular condylar cartilage (15-16 weeks of gestation) were analyzed by immunohistochemistry. Prevascular canals (PVCs), consisting of spindle-shaped cells without capillary invasion, were observed within the cartilage. Intense immunoreactivity for collagen type I, weak immunoreactivity for aggrecan and tenascin-C, weak hyaluronan (HA) staining, and abundant argyrophilic fibers in PVCs indicated that they contain noncartilaginous fibrous connective tissues that was different from those in the perichondrium/periosteum. These structural and immunohistochemical features of PVCs are different from those of previously reported cartilage canals of the long bone. Capillaries entered the VCs from the periosteum and ascended through VCs. Following capillary invasion, loose connective tissue had formed in the lower part of VCs, and immunoreactivity for collagen types I and III, tenascin-C, and HA staining was evident in the matrix of loose connective tissue. No chondroclasts or osteogenic cells were seen at the front of capillary invasion, although small, mononuclear tartrate-resistant acid phosphatase (TRAP)-positive cells were present. Meanwhile, TRAP-positive, multinucleated chondroclasts and flattened, osteoblast-like cells were observed in the loose connective tissue at the lower part of VCs. These results may indicate slow progress of endochondral ossification in human fetal mandibular condyle. Further, unique matrix components in PVCs/VCs, which were different from those in cartilage canals in long bone, may reflect the difference of speed of endochondral ossification in cartilage canals and human fetal mandibular condyles. Anat Rec, 298:1560Rec, 298: -1571Rec, 298: , 2015

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

An Immunohistochemical Study of Matrix Components in Early‐Stage Vascular Canals Within Mandibular Condylar Cartilage in Midterm Human Fetuses

Shibata

Morita

Yokohama-Tamaki

et al. 2015

The Anatomical Record

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Subsets of telocytes: Myocardial telocytes

Rusu

Hostiuc

Vrapciu

et al. 2017

Annals of Anatomy - Anatomischer Anzeiger

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MMP-3 and MMP-8 in rat mandibular condylar cartilage associated with dietary loading, estrogen level, and aging

Yu¹,

Mursu²,

Typpö³

et al. 2019

Archives of Oral Biology

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Objectives: The structure of the mandibular condylar cartilage (MCC) is regulated by dynamic and multifactorial processes. The aim of this study was to examine the effects of altered dietary loading, estrogen level, and aging on the structure of the condylar cartilage and the expressions of matrix metalloproteinase (MMP) -3 and MMP-8 of rat MCC.Methods: In this study, Crl:CD (SD) female rats were randomly divided into 3 groups according to dietary hardness: hard diet (diet board), normal diet (pellet), and soft diet (powder). In each group, the rats were further divided into 2 subgroups by ovariectomy at the age of 7 weeks. The rats were sacrificed at 5-and 14-month-old.Histomorphometric analysis of the MCC thickness was performed after toluidine blue staining. Immunochemical staining was done for MMP-3 and MMP-8. A linear mixed model was used to assess the effects of dietary loading, estrogen level, and aging.Results: Increased dietary loading was the main factor to increase the MMP-3 expression and the anterior and central thickness of the MCC. Lack of estrogen was the main factor associated with decreased MMP-8. Aging was associated with the thickness changes of the whole condylar cartilage and the reduced expression of MMP-8. Conclusion:The condylar cartilage structure and metabolism of the female rats are 2 sensitive to dietary loading changes, estrogen level as well as aging. The proper balance of these factors seems to be essential for the maintenance of the condylar cartilage.

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Morphologic features of the fetal mandibular condyle: Layers, canals and microvascular pattern

Cited by 9 publications

References 22 publications

An Immunohistochemical Study of Matrix Components in Early‐Stage Vascular Canals Within Mandibular Condylar Cartilage in Midterm Human Fetuses

An Immunohistochemical Study of Matrix Components in Early‐Stage Vascular Canals Within Mandibular Condylar Cartilage in Midterm Human Fetuses

Subsets of telocytes: Myocardial telocytes

MMP-3 and MMP-8 in rat mandibular condylar cartilage associated with dietary loading, estrogen level, and aging

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