2010
DOI: 10.5301/ejo.2010.1318 View full text |Buy / Rent full text
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Abstract: In patients with PD with normal vision, we found a decrease in the electrical activity of the fovea as well as in the thickness of the RNFL. Multifocal electroretinogram and OCT scan objectively detect early subclinical PD-associated visual functional impairment.

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“…Previous reports of OCT studies described a thinner RNFL in PD patients (10,11,13) . However, Archibald et al who employed time-domain OCT found no such thinning of the RNFL in PD patients (16) .…”
Section: Discussionmentioning
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“…Previous reports of OCT studies described a thinner RNFL in PD patients (10,11,13) . However, Archibald et al who employed time-domain OCT found no such thinning of the RNFL in PD patients (16) .…”
Section: Discussionmentioning
“…Resultados: A média das idades e desvio-padrão dos pacientes com DP e controles foram respectivamente 63,1 (7,5) e 62,4 (7,2) (10)(11)(12)(13) . Two of these studies found a significant thinning of the peripapillary retinal nerve fibre layer (RNFL) only in the inferior and temporal retinas of some PD patients (10,13) .…”
Section: Métodos: Quarenta E Três Pacientes Com Dp E 38 Controles Prunclassified
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“…7 Moreover, in some neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, the RNFL thinning has been demonstrated with OCT, even in patients without visual loss. 4,5 Considering neurodegenerative ataxias, such as Friedreich's ataxia, alterations in the afferent OCT in SCA-3 G Alvarez et al visual pathway, expressed by a reduction of the RNFL thickness in the OCT can be ascertained. 3 However, in the MJD, and other SCA, despite some results that have been recently published, there are no conclusive studies regarding RNFL and macular thickness variations (except SCA-7 with its cone and rod macular dystrophy associated).…”
Section: Discussionmentioning
“…Moreover, in some neurodegenerative diseases such as Parkinson's and Alzheimer's disease a thinning of the RNFL has been found. 4,5 SCA-3, also known as Machado-Joseph disease (MJD), is the most common form of SCA in Spain, although SCA is a very infrequent disease (the estimated prevalence is about 1-4/100.000). MJD usually begins as a progressive ataxia accompanied by lid retraction and infrequent blinking, ophthalmoparesis, and impaired speech and swallowing.…”
Section: Introductionmentioning