Moroccan study of HLA (-A, -B, -C, -DR, -DQ) polymorphism in 647 unrelated controls: Updating data

Brick, C.; Atouf, O.; Bouayad, Abdellatif; Essakalli, M.

doi:10.1016/j.mcp.2015.04.002

Cited by 16 publications

(5 citation statements)

References 37 publications

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“…This study evidenced that distribution of HLA class II allelic groups and haplotypes was similar among the various Moroccan populations; very small differences in frequencies of haplotypes involved in CD susceptibility have been found between the Moroccan healthy controls employed in this study and the mixed Moroccan population considered in a recent study [ 5 ] (some variability existed only for HLA class I, HLA-A, -B, and haplotypes/associations in Moroccans), confirming previous findings [ 2 ]. A high frequency of DQ2 and DQ8 in the Moroccan population was found, 54.2%, as compared with the 20%–40% of other populations.…”

Section: Discussionsupporting

confidence: 90%

“…HLA allele/haplotype frequency distribution in North Africans showed some differences from European and Mediterranean populations, while more important differences were found compared with sub-Saharans. The mixing of populations and the high polymorphism of HLA alleles are characteristic of Maghreb [ 2 , 3 , 4 , 5 ]. During previous studies, we found that HLA frequencies in this region are intermediate between Sub-Sahara and Europe; some specific HLA alleles and haplotypes that characterize this region could be of interest for clinical purposes.…”

Section: Introductionmentioning

confidence: 99%

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HLA Typing and Celiac Disease in Moroccans

et al. 2017

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Genetic and environmental factors are responsible for differences in the prevalence of some diseases across countries. Human leukocyte antigen (HLA) allele frequencies in North African populations show some differences in their distribution compared to Europeans, Mediterraneans, and sub-Saharans, and some specific alleles and haplotypes could be clinically relevant. Celiac disease (CD) has been fast increasing in prevalence in North Africa; but few immunogenetic data are available for this area, in which a high prevalence of the disease has been described. In this report, we assess and discuss results of HLA class II (HLA-DQA1/DQB1/DRB1) typing in Moroccan patients with CD and compare them with a control population from Morocco—genetically well characterized—and with other North African, Mediterranean, and European populations. The classical HLA-DQ associations were confirmed in Moroccans with CD. The high frequency of DQ2.5 homozygosity (45.2%) found in Moroccans with CD was noteworthy as compared with other populations (23%–32%). The genetic risk gradient for CD, identified by previous studies, has been confirmed in Moroccans with some differences, mainly concerning DQ8 genotypes. This study provides the immunogenetic framework of CD in Moroccans and confirms the need to learn more about associations with additional HLA and non-HLA genetic factors.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

HLA Typing and Celiac Disease in Moroccans

et al. 2017

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“…On the other hand, β‐Thal is the most common form of thalassemia among populations of Mediterranean, North African, and South Asian ancestry. Previous comparisons of genetic distances and haplotypes with other populations have already shown that the Moroccans, North Africans, and Europeans are genetically closer to each other, but distant from sub‐Saharan Africans [11, 30].…”

Section: Discussionmentioning

confidence: 99%

HLA haplotype frequencies and diversity in patients with hemoglobinopathies

Scigliuolo

Boukouaci

Cappelli

et al. 2023

eJHaem

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The genetic diversity of the human leukocyte antigen (HLA) system was shaped by evolutionary constraints exerted by environmental factors. Analyzing HLA diversity may allow understanding of the underlying pathways and offer useful tools in transplant setting. The aim of this study was to investigate the HLA haplotype diversity in patients with sickle cell disease (SCD, N = 282) or β‐thalassemia (β‐Thal, N = 60), who received hematopoietic cell transplantation (HCT) reported to Eurocord and the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM‐TC). We identified 405 different HLA‐A‐B‐DRB1 haplotypes in SCD and 108 in β‐Thal patients. Using data from African and European populations of the “1000 Genomes Project” for comparison with SCD and β‐Thal, respectively, we found that the haplotypes HLA‐A*30‐B*14‐DRB1*15 (OR 7.87, 95% CI: 1.66–37.3, pb = 0.035), HLA‐A*23‐B*08 (OR 6.59, 95% CI: 1.8–24.13, pb = 0.023), and HLA‐B*14‐DRB1*15 (OR 10.74, 95% CI: 3.66–31.57, pb = 0.000) were associated with SCD, and the partial haplotypes HLA‐A*30‐B*13 and HLA‐A*68‐B*53 were associated with β‐Thal (OR 4.810, 95% CI: 1.55–14.91, pb = 0.033, and OR 17.52, 95% CI: 2.81–184.95, pb = 0.011). Our results confirm the extreme HLA genetic diversity in SCD patients likely due to their African ancestry. This diversity seems less accentuated in patients with β‐Thal. Our findings emphasize the need to expand inclusion of donors of African descent in HCT donor registries and cord blood banks.

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“…However, ethnicity is an important factor for the pathogenesis of sepsis, and single nucleotide polymorphisms can be used to distinguish among different ethnic populations. In terms of allele frequencies, a significant difference of G allele was found between Moroccan, African, and Asian populations; however, no difference was found in Mediterranean, European, and Japanese populations [ 44 , 45 ]. In this meta-analysis, 19 of the included studies were conducted in Caucasian and seven in Asian populations.…”

Section: Discussionmentioning

confidence: 99%

Association between the Lymphotoxin-α A252g Gene Polymorphism and the Risk of Sepsis and Mortality: A Meta-Analysis

Guo

Zuo

et al. 2020

BioMed Research International

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Background. The association between the lymphotoxin-α (LTA) A252G polymorphism and sepsis risk has been extensively studied, but the results have been controversial. This study is aimed at investigating the overall association between the LTA A252G polymorphism and the risk of sepsis/septic shock and sepsis-related mortality. Methods. We searched the PubMed and EMBASE databases to identify studies that investigated the association between the LTA A252G polymorphism and risks of sepsis, septic shock, and mortality. The relevant data were extracted, and statistical analyses were performed using the Revman 5.0 and STATA 12 software. Results. A total of 32 publications were included in the meta-analysis. The results demonstrated that the LTA A252G polymorphism showed no significant association with sepsis risk (GG+GA vs. AA: OR=0.92, 95%CI=0.79–1.07, p=0.27) or with sepsis shock risk (GG+GA vs. AA: OR=1.01, 95%CI=0.84–1.22, p=0.91). However, in the subgroup analyzed by ethnicity, the LTA A252G polymorphism significantly decreased sepsis risk in the Asian population for the recessive model [GG vs. GA+AA: OR=0.82, 95%CI=0.68–0.99, p=0.04] but not in the Caucasian population. Moreover, comparisons between sepsis patients who survived and those who did not suggested that the LTA A252G polymorphism decreases the risk of mortality [GG+GA vs. AA: OR=0.57, 95%CI=0.41–0.80, p<0.01]. Conclusion. Our results suggested that the A252G polymorphism in the LTA gene decreased the risk of sepsis in Asians and may reduce mortality in septic individuals.

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Moroccan study of HLA (-A, -B, -C, -DR, -DQ) polymorphism in 647 unrelated controls: Updating data

Cited by 16 publications

References 37 publications

HLA Typing and Celiac Disease in Moroccans

HLA Typing and Celiac Disease in Moroccans

HLA haplotype frequencies and diversity in patients with hemoglobinopathies

Association between the Lymphotoxin-α A252g Gene Polymorphism and the Risk of Sepsis and Mortality: A Meta-Analysis

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