Morning Glory Disc Anomaly With Peripheral Retinal Nonperfusion in 4 Consecutive Cases

A case of anterior persistent hyperplastic primary vitreous associated with morning glory disc anomaly and retinopathy of prematurity like retinopathy in a term-born child

“…MGDA associated with peripheral retinal nonperfusion has been reported and well recognized. The peripheral avascular retina attributed by the anomaly of defected optic disc is the character of MGDA [ 10 , 12 , 13 ], which is exactly the same showed in our case. The endings of the peripheral retinal vessels at the junction between the retinal perfusion and retinal non-perfusion zone in MGDA presented as increasing in numbers of branches with fine tips without fluorescein leakage, just like “brushfire “.…”

A case of anterior persistent hyperplastic primary vitreous associated with morning glory disc anomaly and retinopathy of prematurity like retinopathy in a term-born child

“…MGDA associated with peripheral retinal nonperfusion has been reported and well recognized. The peripheral avascular retina attributed by the anomaly of defected optic disc is the character of MGDA [ 10 , 12 , 13 ], which is exactly the same showed in our case. The endings of the peripheral retinal vessels at the junction between the retinal perfusion and retinal non-perfusion zone in MGDA presented as increasing in numbers of branches with fine tips without fluorescein leakage, just like “brushfire “.…”

Macular Cavernous Hemangioma Associated With Peripheral Vascular Anomalies and Nonperfusion

“…16 Rojanaporn reported peripheral nonperfusion, peripheral vascular loops and "brushfire" retinal vessels at the vascularavascular junction in four cases with morning glory discs. 17 Although the optic disc was unremarkable in this case and genetics were unavailable, the macular and peripheral changes may represent a continuum of phenotypic features found either in cavernous hemangiomas or previously unrecognized congenital abnormalities associated with peripheral nonperfusion. Alternatively, the peripheral findings may be a separate clinical entity, such as a concurrent stage 1 familial exudative vitreoretinopathy.…”

A Case-Oriented Therapeutic Approach Based on Evidence of Retinal Metabolic Demand in Juxtapapillary Capillary Hemangiomas as Part of von Hippel-Lindau Disease

“…As the development of retinal vessels has been proved to be associated with the migration of astrocytes and a vascular precursor through the optic nerve, an abnormality of the optic nerve with the development of retinal vessels is possible. This has been advanced in a sample of four patients with a morning glory disc anomaly, where the association between retinal vessel maldevelopment of the optic disc with peripheral retinal non-perfusion has been supposed 16 . Based on the discussed, we also postulate a connection between JPHs in the sense of a vascular malformation with consecutive effects on peripheral blood flow seen in our case.…”

A case of anterior persistent hyperplastic primary vitreous associated with morning glory disc anomaly and retinopathy of prematurity like retinopathy in a term-born child

“…MGDA associated with peripheral retinal nonperfusion has been reported and well recognized. The peripheral avascular retina attributed by the anomaly of defected optic disc is the character of MGDA [ 10 , 12 , 13 ], which is exactly the same showed in our case. The endings of the peripheral retinal vessels at the junction between the retinal perfusion and retinal non-perfusion zone in MGDA presented as increasing in numbers of branches with fine tips without fluorescein leakage, just like “brushfire “.…”

Macular Cavernous Hemangioma Associated With Peripheral Vascular Anomalies and Nonperfusion

“…16 Rojanaporn reported peripheral nonperfusion, peripheral vascular loops and "brushfire" retinal vessels at the vascularavascular junction in four cases with morning glory discs. 17 Although the optic disc was unremarkable in this case and genetics were unavailable, the macular and peripheral changes may represent a continuum of phenotypic features found either in cavernous hemangiomas or previously unrecognized congenital abnormalities associated with peripheral nonperfusion. Alternatively, the peripheral findings may be a separate clinical entity, such as a concurrent stage 1 familial exudative vitreoretinopathy.…”

A Case-Oriented Therapeutic Approach Based on Evidence of Retinal Metabolic Demand in Juxtapapillary Capillary Hemangiomas as Part of von Hippel-Lindau Disease

“…As the development of retinal vessels has been proved to be associated with the migration of astrocytes and a vascular precursor through the optic nerve, an abnormality of the optic nerve with the development of retinal vessels is possible. This has been advanced in a sample of four patients with a morning glory disc anomaly, where the association between retinal vessel maldevelopment of the optic disc with peripheral retinal non-perfusion has been supposed 16 . Based on the discussed, we also postulate a connection between JPHs in the sense of a vascular malformation with consecutive effects on peripheral blood flow seen in our case.…”

A case of anterior persistent hyperplastic primary vitreous associated with morning glory disc anomaly and retinopathy of prematurity like retinopathy in a term-born child

“…MGDA associated with peripheral retinal nonperfusion has been reported and well recognized. The peripheral avascular retina attributed by the anomaly of defected optic disc is the character of MGDA [ 10 , 12 , 13 ], which is exactly the same showed in our case. The endings of the peripheral retinal vessels at the junction between the retinal perfusion and retinal non-perfusion zone in MGDA presented as increasing in numbers of branches with fine tips without fluorescein leakage, just like “brushfire “.…”

Macular Cavernous Hemangioma Associated With Peripheral Vascular Anomalies and Nonperfusion

“…16 Rojanaporn reported peripheral nonperfusion, peripheral vascular loops and "brushfire" retinal vessels at the vascularavascular junction in four cases with morning glory discs. 17 Although the optic disc was unremarkable in this case and genetics were unavailable, the macular and peripheral changes may represent a continuum of phenotypic features found either in cavernous hemangiomas or previously unrecognized congenital abnormalities associated with peripheral nonperfusion. Alternatively, the peripheral findings may be a separate clinical entity, such as a concurrent stage 1 familial exudative vitreoretinopathy.…”

A Case-Oriented Therapeutic Approach Based on Evidence of Retinal Metabolic Demand in Juxtapapillary Capillary Hemangiomas as Part of von Hippel-Lindau Disease

“…As the development of retinal vessels has been proved to be associated with the migration of astrocytes and a vascular precursor through the optic nerve, an abnormality of the optic nerve with the development of retinal vessels is possible. This has been advanced in a sample of four patients with a morning glory disc anomaly, where the association between retinal vessel maldevelopment of the optic disc with peripheral retinal non-perfusion has been supposed 16 . Based on the discussed, we also postulate a connection between JPHs in the sense of a vascular malformation with consecutive effects on peripheral blood flow seen in our case.…”