Morita–Baylis–Hillman adducts derived from thymol: synthesis, in silico studies and biological activity against Giardia lamblia

Xavier, Francisco José Seixas; Lira, Andressa Brito; Veríssimo, Gabriel Corrêa; Saraiva, Fernanda Samara de Sousa; Filho, Abrahão Alves de Oliveira; Souza-Fagundes, Elaine Maria de; Diniz, Margareth de Fátima Formiga Melo; Gomes, Maria Aparecida; Castro, Aleff Cruz de; Silva, Fábio P.L.; Lima-Júnior, Cláudio Gabriel; Vasconcellos, Mário L. A. A.

doi:10.1007/s11030-021-10308-1

Mol Divers

2021

DOI: 10.1007/s11030-021-10308-1

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Morita–Baylis–Hillman adducts derived from thymol: synthesis, in silico studies and biological activity against Giardia lamblia

Francisco José Seixas Xavier

Andressa Brito Lira

Gabriel Corrêa Veríssimo

et al.

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Cited by 2 publications

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Synthesis, biological activities, and structure–activity relationships of Morita–Baylis–Hillman adducts: An update

Devi,

Pathania,

Singh

et al. 2024

Archiv der Pharmazie

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The Morita–Baylis–Hillman (MBH) reaction is a unique C–C bond‐forming technique for the generation of multifunctional allylic alcohols (MBH adducts) in a single operation. In recent years, these MBH adducts have emerged as a novel class of compounds with significant biological potential, including anticancer, anti‐leishmanial, antibacterial, antifungal, anti‐herbicidal effects and activity against Chagas disease, and so on. The aim of this review is to assimilate the literature findings from 2011 onwards related to the synthesis and biological potential of MBH adducts, with an emphasis on their structure–activity relationships (SAR). Although insight into the biological mechanisms of action for this recently identified pharmacophore is currently in its nascent stages, the mechanisms described so far are reviewed herein.

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Synthesis, biological activities, and structure–activity relationships of Morita–Baylis–Hillman adducts: An update

Devi,

Pathania,

Singh

et al. 2024

Archiv der Pharmazie

View full text Add to dashboard Cite

show abstract

Assessment of Morita-Baylis-Hillman adducts as novel modulators of quorum sensing phenotypes in Chromobacterium CV026 by targeting CviR

Cunha

Favero

Souza

et al. 2023

Tetrahedron Letters

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Morita–Baylis–Hillman adducts derived from thymol: synthesis, in silico studies and biological activity against Giardia lamblia

Cited by 2 publications

References 60 publications

Synthesis, biological activities, and structure–activity relationships of Morita–Baylis–Hillman adducts: An update

Synthesis, biological activities, and structure–activity relationships of Morita–Baylis–Hillman adducts: An update

Assessment of Morita-Baylis-Hillman adducts as novel modulators of quorum sensing phenotypes in Chromobacterium CV026 by targeting CviR

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