Moringa oleifera phytochemicals protect the brain against experimental nicotine-induced neurobehavioral disturbances and cerebellar degeneration

Omotoso, Gabriel Olaiya; Gbadamosi, Ismail Temitayo; Olajide, Olayemi Joseph; Dada-Habeeb, Shakirat Opeyemi; Arogundade, Tolulope Timothy; Yawson, Emmanuel

doi:10.1016/j.pathophys.2017.12.003

Cited by 39 publications

(25 citation statements)

References 21 publications

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“…Leaf extracts of M. oleifera presented a positive result for the treatment of atopic dermatitis, with the reduction of serum level of IgE and the clinical characteristics [15]. The aqueous extract of the leaf, with phytochemical compounds, was an important target in neural studies, with action of nicotine, the authors revealed that the aqueous extract was able to prevent chromatolysis, distortion of cerebellar cortical cells and neurobehavioral deficit, in mice treated with nicotine [16]. The hydroethanolic extract of the leaves showed antioxidant activity [17].…”

Section: Resultsmentioning

confidence: 99%

<em>MORINGA OLEIFERA</em>: A NEW PERSPECTIVE FOR THE SYNTHESIS OF NATURAL PRODUCTS

Silva

Bezerra

Sousa

et al. 2018

Proceedings of MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th Edition

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Moringa oleifera Lam. is a plant native from India, but its distribution extends to all continents. Its leaves, flowers, pods and seeds are commonly used for food, mainly in Africa, due to its high nutritional value. With regard to medicine, M. oleifera demonstrates immeasurable potential in view of the various biological activities which are reported from its secondary compounds, such as alkaloids, tannins, flavonols, steroids, saponins, coumarins, quinones, resins, lectins among others. Based on this assumption, this review aims to expose the potential of Moringa oleifera in the period 2016-2018, in the use of its compounds for the synthesis of natural products due to its diverse biological activities. The results showed that the several parts of the plant may have different biological activities. The seeds have antibacterial activity with dental importance; activity in the prevention and deceleration of the amyotrophic lateral sclerosis disease (ALS); anti-hypertrophic and anti-fibrotic effect, being beneficial for cardiac structure and function in hypertensive mice; anticancer activity; anti-inflammatory; and protection of neural cells. For the leaves were reported Antitumor activities; therapeutic efficacy against neurotoxicity; for insulin expression and decrease in the degree of insulitis; antimicrobial activity; reduction of myocardial damage and oxidative stress; treatment in atopic dermatitis; gastroprotective activity and improvement of mucus; hypocholesterolemic effect; and ability to prevent chromatolysis, distortion of cerebellar cortical cells and neurobehavioral deficit. For the other parts of the plant similar activities are described, however in less quantity. Thus, Moringa oleifera presents a new perspective on the synthesis of natural products, considering the range of biological activities described for a species, as well as the ease of obtaining and using its compounds.

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Section: Resultsmentioning

confidence: 99%

<em>MORINGA OLEIFERA</em>: A NEW PERSPECTIVE FOR THE SYNTHESIS OF NATURAL PRODUCTS

Silva

Bezerra

Sousa

et al. 2018

Proceedings of MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th Edition

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“…Previous studies showed that rodents treated by nicotine lost a signifi cant amount of white matter (1 4 -16). Gabriel Olaiya Omotoso et al, has shown that Moringa oleifera could prevent nicotine-induced cerebellar injury in Wistar rats (17 ) .…”

Section: Introductionmentioning

confidence: 99%

Low concentration of morphine protects against cell death, oxidative stress and calcium accumulation by nicotine in PC12 cells

Amini¹,

Zhaleh²,

Tahvilian³

et al. 2019

BLL

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OBJECTIVE: Nicotine causes cell death in many cell lines. Morphine at low concentrations has protective effects against cell death. We investigated the effects of low concentration of morphine on nicotine-induced cell death in PC12 cells. MATERIALS AND METHODS: PC12 are cells that grow in DMEM culture medium. Cell viability was detected by MTT test and cells cytotoxicity was measured by LDH test. The activity of caspase-3 was diagnosed by the caspase activity colorimetric assay kit, and detection of mitochondrial membrane potential was confi rmed by rhodamine 123 and TUNEL test was performed for DNA fragmentation detection. The fura-2 AM and also rhod 2-AM was used for measurement of intracellular calcium (Ca 2+) ic and mitochondrial calcium (Ca 2+) m and fi nally, measurement of antioxidant enzyme activities was assessed. RESULTS: The low concentration of morphine increased cell viability and suppressed cell cytotoxicity, cell death and the formation of mitochondrial membrane potential compared to nicotine treated cells. It also reduced the intracellular calcium (Ca 2+) ic and mitochondrial calcium (Ca 2+)m concentration, respectively. CONCLUSION: Morphine as a pain reducer drug, in low concentrations, can protect PC12 cells from nicotineinduced cell death (Fig. 7, Ref. 59).

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“…The international nutritional supplement market has seen quick growth with the trend expected to continue (Omotoso, 2018 andAri-egoro et al, 2019). Leaves can be eaten fresh, cooked and kept its powder in the absence of cooling and without nutritional properties being reduced.…”

Section: Introductionmentioning

confidence: 99%

Usage of Moringa Leaves as a Component in some Foodstuff

Abouel-Yazeed

2019

Journal of Food and Dairy Sciences

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The target of this investigation was to determine the chemical analysis besides the characteristic of the application of Egyptian Moringa oleifera leaves. Results found that the proximate analysis of moringa leaves are rich in protein, carbohydrate and fiber (23.14, 53.63 and10.61%, respectively). Moringa leaves are a good source of essential amino acids such as leucine, lysine and valine as follows (22.19, 15.18 and 13.79%, respectively).Moreover, major fatty acids in Moringa leaves were oleic acid (C 18:1) (40.24%), linolenic acid (C 18:2) (19.43%), palmitic acid(C 16:0) (15.63%) as well as linoleic acid (C 18:2) (7.95 %) .Furthermore, essential minerals especially Ca and K. Results also showed that having an abundance of bioactive components and natural antioxidants (phenolic content (33.12 mg GAE/g extract), flavonoids content (18.12 mg/g), ascorbic acid content (17.67 mg/100g) and antioxidant activity (78.98%). Generally, the sensory quality of application fortified with leaves powder for potential with the item in food confirmed that the ability to use it as additives or food fortification. The best of the sensory assessments showed that, the Mentha /Moringa in tea bags was (97% Mentha + 3% Moringa), prepared salad using Moringa as a spice and fortification was (99.4% salad + 0.6% Moringa) and the crackers (snack) products was (95% wheat flour + 5% Moringa). As a result, it is suggested that recommendation to improve the consumption from it to treat malnutrition in developing countries.

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Moringa oleifera phytochemicals protect the brain against experimental nicotine-induced neurobehavioral disturbances and cerebellar degeneration

Cited by 39 publications

References 21 publications

<em>MORINGA OLEIFERA</em>: A NEW PERSPECTIVE FOR THE SYNTHESIS OF NATURAL PRODUCTS

<em>MORINGA OLEIFERA</em>: A NEW PERSPECTIVE FOR THE SYNTHESIS OF NATURAL PRODUCTS

Low concentration of morphine protects against cell death, oxidative stress and calcium accumulation by nicotine in PC12 cells

Usage of Moringa Leaves as a Component in some Foodstuff

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