Morinda citrifolia (Noni): A comprehensive review on its industrial uses, pharmacological activities, and clinical trials

Assi, Reem Abou; Darwis, Yusrida; Abdulbaqi, Ibrahim M.; Khan, Arshad Ali; Lim, Vuanghao; Laghari, Madeeha

doi:10.1016/j.arabjc.2015.06.018

Cited by 155 publications

(87 citation statements)

References 81 publications

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“…The results obtained suggest to better explore, on larger case series, the advantage of this particular association of nutraceuticals, whose action mechanisms are of particularly suitable interest in UTIs prevention. The synergy between D-mannose, N-acetylcysteine, and Morinda citrifolia fruit extract, has suggested a great role in recurrent UTIs prevention (15)(16)(17)(18)(19)(20)(21). A larger experience is needed, also in different type of populations, to amplify the outcomes shown in the present study.…”

Section: Discussionmentioning

confidence: 85%

Prospective study to compare antibiosis versus the association of N-acetylcysteine, D-mannose and Morinda citrifolia fruit extract in preventing urinary tract infections in patients submitted to urodynamic investigation

Palleschi

Carbone

Zanello³

et al. 2017

Arch Ital Urol Androl

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Background: The abuse of antimicrobical drugs has increased the resistance of microorganisms to treatments, thus to make urinary tract infections (UTIs) more difficult to eradicate. Among natural substances used to prevent UTI, literature has provided preliminary data of the beneficial effects of D-mannose, N-acetylcysteine, and Morinda citrifolia fruit extract, due to their complementary mechanism of action which contributes respectively to limit bacteria adhesion to the urothelium, to destroy bacterial pathogenic biofilm, and to the anti-inflammatory and analgesic activity. The purpose of this study was to compare the administration of an association of D-mannose, N-acetylcysteine (NAC) and Morinda citrifolia extract versus antibiotic therapy in the prophylaxis of UTIs potentially associated with urological mini-invasive diagnostics procedures, in clinical model of the urodynamic investigation. Methods: 80 patients eligible for urodynamic examination, 42 men and 38 women, have been prospectively enrolled in the study and randomised in two groups (A and B) of 40 individuals. Patients of group A followed antibiotic therapy with Prulifloxacine, by mouth 400 mg/day for 5 days, while patients of the group B followed the association of mannose and NAC therapy, two vials/day for 7 days. Ten days after the urodynamic study, the patients were submitted to urine examination and urine culture. Results: The follow up assessment didn't show statistical significant difference between the two groups regarding the incidence of UTI. Conclusions: The association of mannose and NAC therapy resulted similar to the antibiotic therapy in preventing UTIs in patients submitted to urodynamic examination. This result leads to consider the possible use of these nutraceutical agents as a good alternative in the prophylaxis of the UTI afterwards urological procedures in urodynamics.

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Section: Discussionmentioning

confidence: 85%

Prospective study to compare antibiosis versus the association of N-acetylcysteine, D-mannose and Morinda citrifolia fruit extract in preventing urinary tract infections in patients submitted to urodynamic investigation

Palleschi

Carbone

Zanello³

et al. 2017

Arch Ital Urol Androl

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“…Noni possesses around 200 biologically and pharmacologically active compounds in widely varied structural classes, well documented by Singh (2012), Saminathan et al (2013), Assi et al (2015), and Krishnakumar et al (2015). Of these, several phenolic compounds, vitamin C and some lignans were suggested to be responsible for antioxidative activity (Kamiya et al 2004, Su et al 2005, Dussossoy et al 2011, Singh 2012, Saminathan et al 2013, Krishnakumar et al 2015.…”

Section: Discussionmentioning

confidence: 95%

“…Although first studies on this plant date back to the beginning of 1990s, with two publications in the years of 1907 and 1918 (Simonsen 1920), numerous in vitro and in vivo investigations and clinical trials have started with the advent of noni juice as a health and wellness drink in 1996 and its approval as a novel food by the European Commission in 2003 (Palu et al 2008, Basar et al 2010, Glang et al 2013. Diverse bioactive and therapeutic properties of noni have recently been reviewed by Assi et al (2015), Krishnakumar et al (2015), Motshakeri and Ghazali (2015), Nerurkar et al (2015), and Raja and Sreenivasulu (2015) comprehensively. In addition to its human health benefits, noni was reported to have beneficial effects on animal health and productivity (Retnani et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Along with its consumption as food and a dye for traditional clothes (Palu et al 2008(Palu et al , 2010, the fruit, leaf, root, seed, bark, stem and flower of this plant have been topically and internally used solely or combined in traditional medicine for over 2000 years in Polynesia to cure and prevent a broad range of human diseases which can be found in reviews by Wang et al (2002), Mathivanan et al (2005), Chan-Blanco et al (2006), Pawlus and Kinghorn (2007), Singh (2012), Gupta and Patel (2013), Saminathan et al (2013), Assi et al (2015), Krishnakumar et al (2015), Motshakeri and Ghazali (2015), Nerurkar et al (2015), and Raja and Sreenivasulu (2015).…”

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confidence: 99%

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Antioxidant and Anti-inflammatory Activities of a Commercial Noni Juice revealed by Carrageenan-induced Paw Edema

Yilmazer¹,

Coşkun²,

Gürel-Gürevin³

et al. 2016

Polish Journal of Veterinary Sciences

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This study aimed to investigate antioxidant and anti-inflammatory activities of a commercial product of noni (Morinda citrifolia) juice. Carrageenan-induced rat paw edema was employed as inflammatory model. One control and three experimental groups were formed. Experimental groups were administered noni juice alone, noni juice+carrageenan, and carrageenan alone. Oxidant and antioxidant capacity were determined by d-ROMs test and BAP test, respectively. Plasma concentrations of endothelin-1 and leptin were measured by ELISA. Measurements were performed at zero time and 2nd hour of inflammation. Oxidant capacity decreased in noni-received groups at 2nd hour (p=0.019). Antioxidant capacity of the group which received noni alone was found to be higher at 2nd hour (p=0.036). Plasma concentrations of endothelin-1 and leptin were notably lower in noni-received groups (p=0.001 and p=0.021, respectively). The results show that the commercial noni juice investigated has pronounced antioxidant and anti-inflammatory activities.

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“…This demonstrates that fibroblast cell proliferation in all treatment groups had reduced earlier than in the control group, which indicates that noni leaf pastes can help wounds to heal faster. 3,21 Many active constituents of noni leaf extract are believed to promote faster wound healing and closure and accelerate fibroblast cell maturation. Saponin, for example, has antibacterial properties and may lower the risk of infection.…”

Section: Discussionmentioning

confidence: 99%

Benefits of Ethanolic Extract Paste of Noni (Morinda citrifolia L.) Leaves on Oral Mucosa Wound Healing by Examination of Fibroblast Cells

Sabirin¹,

Yuslianti²

2016

J Dent Indones

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Wound healing is a biological response that occurs following a trauma or pathologic condition of the oral mucosa. Wounds require proper management so they may heal faster and without complication. The number of fibroblast cells seen in the oral mucosa is a strong indicator of wound healing. In the remodelling phase of wound healing, fibroblast cell proliferation decreases as collagen fibres are synthesized. Noni leaf (Morinda citrifolia L.), a part of the noni plant, is traditionally used to heal soft tissue wounds in Indonesia. The leaves have potential chemical compounds that may be useful in the wound repair process. Objective: This paper aims to examine the effect of ethanol based pastes of the Indonesian noni leaf on oral mucosa wound healing by investigating visual wound closure and fibroblast cell counts in Wistar rats. Methods: Rats were divided into 2 control groups and 4 treatment groups. The pastes were formulated in concentrations of 2.5%, 5%, 10%, and 20% and were applied onto wounds of the oral mucosa of the rats. One control group was given no medication and the other control group had an ethanol gel with a concentration of 10% noni leaf extract applied to their intraoral wounds. Result: Result revealed that all groups treated with noni leaf paste experienced better wound closure (p<0.05) when compared to the control groups. Fibroblast cell counts showed little significance amongst all groups (p=0.143), however fibroblast cell counts of groups treated with noni leaf paste, of all concentrations, were lower than both control groups. Conclusion: These results suggest that topical application of noni leaf paste promotes better oral mucosa wound healing than gel formulas but shows no significant difference in the amounts of fibroblasts during the remodelling phase.

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Morinda citrifolia (Noni): A comprehensive review on its industrial uses, pharmacological activities, and clinical trials

Cited by 155 publications

References 81 publications

Prospective study to compare antibiosis versus the association of N-acetylcysteine, D-mannose and Morinda citrifolia fruit extract in preventing urinary tract infections in patients submitted to urodynamic investigation

Prospective study to compare antibiosis versus the association of N-acetylcysteine, D-mannose and Morinda citrifolia fruit extract in preventing urinary tract infections in patients submitted to urodynamic investigation

Antioxidant and Anti-inflammatory Activities of a Commercial Noni Juice revealed by Carrageenan-induced Paw Edema

Benefits of Ethanolic Extract Paste of Noni (Morinda citrifolia L.) Leaves on Oral Mucosa Wound Healing by Examination of Fibroblast Cells

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