Morinda citrifolia fruit reduces stress-induced impairment of cognitive function accompanied by vasculature improvement in mice

Muto, Junko; Lee, Hosung; Uwaya, Akemi; Isami, Fumiyuki; Ohno, Makoto; Mikami, Toshio

doi:10.1016/j.physbeh.2010.04.014

Cited by 34 publications

(25 citation statements)

References 29 publications

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“…Likewise, in another report, an ethyl acetate extract of noni fruit prevented beta-amyloid (25–35)-induced cognitive dysfunction in mice [23]. In addition, administration of noni fruit juice protected brains from stress-induced impairment of cognitive function [24]. Given these results, it seems unlikely that the observed attenuation of ethanol CPP by TNJ in the current study can be accounted for by drug-induced memory impairment.…”

Section: Discussionsupporting

confidence: 72%

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Noni (<i>Morinda citrifolia</i> Linn.) fruit juice attenuates the rewarding effect of ethanol in conditioned place preference in mice

Pandy

Khan

2016

Exp. Anim.

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Morinda citrifolia L. commonly known as noni or Indian mulberry belongs to the family Rubiaceae. Noni fruit juice has recently become a very popular remedy for the treatment of several diseases, including psychiatric disorders. This study aimed to investigate the anticraving effect of Tahitian Noni® Juice (TNJ) against ethanol seeking behavior in ICR male mice using the conditioned place preference (CPP) test. The CPP procedure consisted of four phases: preconditioning, conditioning, extinction, and reinstatement. During conditioning, intraperitoneal (i.p.) injections of ethanol (2 g/kg body weight (bw)) and normal saline (10 ml/kg bw) were given on alternate days for 12 days. Then, the animals were subjected to extinction trials for the next 12 days to weaken CPP. Finally, CPP was reinstated in the extinguished animals by a single low-dose priming injection of ethanol (0.4 g/kg bw, i.p.). The effect of TNJ (as a source of drinking water) on different phases of ethanol CPP in mice was studied. TNJ-treated mice showed a significant reduction in ethanol seeking behavior in the CPP test. The reference drug, acamprosate (ACAM) also showed a similar effect in the CPP test. The outcome of this study suggests that TNJ is effective in attenuating ethanol craving in mice and could be utilized for the treatment of alcohol dependence. Further clinical studies in this direction are warranted to support the present preclinical findings.

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Section: Discussionsupporting

confidence: 72%

“…These results confirmed the safety of noni juice in subacute treatment for 30 days. Recently, noni juice has been reported to have nootropic activity in stress-induced cognitively impaired mice using the Morris water maze (MWM) test [24]. …”

Section: Discussionmentioning

confidence: 99%

Noni (<i>Morinda citrifolia</i> Linn.) fruit juice attenuates the rewarding effect of ethanol in conditioned place preference in mice

Pandy

Khan

2016

Exp. Anim.

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“…They suggested that Noni juice protect brain from stress-induced impairment of cognitive function and reported this protective effect may be related to improvement in stress-induced decrease in blood vessel density in the hippocampal dentate gyrus. 57 …”

Section: Effect On Cognitive Functionmentioning

confidence: 99%

Health Benefits of Morinda citrifolia (Noni): A Review

Ali¹,

Kenganora²,

Manjula³

2016

Phcogj

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Background: Morinda citrifolia (Noni) has been used widely as a comple mentary and alternative therapy in many countries owing to its potent anti oxidant activity and proven health benefits. Traditionally, it finds used as a therapeutic remedy to various diseases as an antibacterial, antitumor, anthelminthic, analgesic, anti inflammatory, immunostimulant. Also it has proved beneficial in conditions like gastritis, skin diseases, respiratory infections, menstrual and urinary tract disorders, fever, diabetes and venereal diseases. Objective: This review emphasizes on the phytochemical and mineral profile of the different parts of Noni plant. In addition, this review corroborates the pharmacological basis for the various health benefits, traditional and medicinal applications of Noni. Materials and Methods: All the available information of Noni were collected from electronic databases such as Academic Journals, Ethnobotany, Ethnopharmacology, Springer, PubMed, Google Scholar, Science Direct and other primary and secondary sources. Results: According to our search results pertaining to scientific literature, Morinda citrifolia is used for more than 40 types of ailments worldwide. Crude extract of various parts of plant and fruit juice are reported

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“…Another finding suggested that the administration of Noni fruit juice protects brains from stress-induced impairment of cognitive function and that this protective effect may be related to improvement in stress-induced decreases in blood vessel density in the hippocampal dentate gyrus (Muto et al, 2010).…”

Section: Noni and Stress-induced Impairment Of Cognitive Functionmentioning

confidence: 99%

Do the Health Claims Made for Morinda citrifolia (Noni) Harmonize with Current Scientific Knowledge and Evaluation of its Biological Effects

Gupta

Patel²

2013

Asian Pacific Journal of Cancer Prevention

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Morinda citrifolia fruit reduces stress-induced impairment of cognitive function accompanied by vasculature improvement in mice

Cited by 34 publications

References 29 publications

Noni (<i>Morinda citrifolia</i> Linn.) fruit juice attenuates the rewarding effect of ethanol in conditioned place preference in mice

Noni (<i>Morinda citrifolia</i> Linn.) fruit juice attenuates the rewarding effect of ethanol in conditioned place preference in mice

Health Benefits of Morinda citrifolia (Noni): A Review

Do the Health Claims Made for Morinda citrifolia (Noni) Harmonize with Current Scientific Knowledge and Evaluation of its Biological Effects

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