Biochemical Pharmacology volume 77, issue 9, P1506-1512 2009 DOI: 10.1016/j.bcp.2009.01.019 View full text
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Jie Wan Kim, Jun Ho Lee, Bang Yeon Hwang, Se Hwan Mun, Na Young Ko, Do Kyun Kim, Bokyung Kim, Hyung Sik Kim, Young Mi Kim, Wahn Soo Choi

Abstract: Mast cells are responsible for IgE-mediated allergic responses. Although dietary flavonoid morin has been known to suppress mast cell activation, its in vivo anti-allergic activity and the underlying mechanisms remain are largely unknown. In this study, we determine whether morin suppresses IgE-mediated allergic responses in an animal model and its mechanism of action. Morin suppressed IgE-mediated PCA in mice (ED50 23.9 mg/kg) and inhibited degranulation and production of tumor necrosis factor-alpha (TNF-alph…

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