Biochemical Pharmacology volume 77, issue 9, P1506-1512 2009 DOI: 10.1016/j.bcp.2009.01.019 View full text
Jie Wan Kim, Jun Ho Lee, Bang Yeon Hwang, Se Hwan Mun, Na Young Ko, Do Kyun Kim, Bokyung Kim, Hyung Sik Kim, Young Mi Kim, Wahn Soo Choi

Abstract: Mast cells are responsible for IgE-mediated allergic responses. Although dietary flavonoid morin has been known to suppress mast cell activation, its in vivo anti-allergic activity and the underlying mechanisms remain are largely unknown. In this study, we determine whether morin suppresses IgE-mediated allergic responses in an animal model and its mechanism of action. Morin suppressed IgE-mediated PCA in mice (ED50 23.9 mg/kg) and inhibited degranulation and production of tumor necrosis factor-alpha (TNF-alph…

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